UBL7_MOUSE
ID UBL7_MOUSE Reviewed; 380 AA.
AC Q91W67; E9Q1S0; Q9D7P5;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Ubiquitin-like protein 7;
GN Name=Ubl7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP STRUCTURE BY NMR OF 1-94.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the N-terminal ubiquitin-like domain in mouse
RT ubiquitin-like protein SB132.";
RL Submitted (OCT-2005) to the PDB data bank.
CC -!- SUBUNIT: Binds ubiquitin. {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK009025; BAB26033.1; -; mRNA.
DR EMBL; AC122534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016456; AAH16456.1; -; mRNA.
DR CCDS; CCDS23234.1; -.
DR RefSeq; NP_001116345.1; NM_001122873.1.
DR RefSeq; NP_081362.2; NM_027086.3.
DR RefSeq; XP_006511469.1; XM_006511406.3.
DR RefSeq; XP_006511470.1; XM_006511407.2.
DR RefSeq; XP_006511471.1; XM_006511408.2.
DR PDB; 1X1M; NMR; -; A=1-94.
DR PDBsum; 1X1M; -.
DR AlphaFoldDB; Q91W67; -.
DR BMRB; Q91W67; -.
DR SMR; Q91W67; -.
DR BioGRID; 213461; 6.
DR STRING; 10090.ENSMUSP00000126019; -.
DR iPTMnet; Q91W67; -.
DR PhosphoSitePlus; Q91W67; -.
DR EPD; Q91W67; -.
DR jPOST; Q91W67; -.
DR MaxQB; Q91W67; -.
DR PaxDb; Q91W67; -.
DR PRIDE; Q91W67; -.
DR ProteomicsDB; 297790; -.
DR Antibodypedia; 26955; 125 antibodies from 23 providers.
DR DNASU; 69459; -.
DR Ensembl; ENSMUST00000163329; ENSMUSP00000126019; ENSMUSG00000055720.
DR Ensembl; ENSMUST00000216841; ENSMUSP00000149748; ENSMUSG00000055720.
DR Ensembl; ENSMUST00000216925; ENSMUSP00000150925; ENSMUSG00000055720.
DR GeneID; 69459; -.
DR KEGG; mmu:69459; -.
DR UCSC; uc009pvx.2; mouse.
DR CTD; 84993; -.
DR MGI; MGI:1916709; Ubl7.
DR VEuPathDB; HostDB:ENSMUSG00000055720; -.
DR eggNOG; KOG0010; Eukaryota.
DR GeneTree; ENSGT00390000015967; -.
DR HOGENOM; CLU_036815_2_0_1; -.
DR InParanoid; Q91W67; -.
DR OMA; HAINLLM; -.
DR OrthoDB; 975164at2759; -.
DR PhylomeDB; Q91W67; -.
DR TreeFam; TF327176; -.
DR BioGRID-ORCS; 69459; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Ubl7; mouse.
DR EvolutionaryTrace; Q91W67; -.
DR PRO; PR:Q91W67; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q91W67; protein.
DR Bgee; ENSMUSG00000055720; Expressed in spermatid and 217 other tissues.
DR ExpressionAtlas; Q91W67; baseline and differential.
DR Genevisible; Q91W67; MM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00165; UBA; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Phosphoprotein; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..380
FT /note="Ubiquitin-like protein 7"
FT /id="PRO_0000211022"
FT DOMAIN 18..98
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT DOMAIN 333..377
FT /note="UBA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT REGION 200..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 230
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 35
FT /note="L -> P (in Ref. 1; BAB26033)"
FT /evidence="ECO:0000305"
FT CONFLICT 228
FT /note="G -> A (in Ref. 1; BAB26033)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="Q -> H (in Ref. 1; BAB26033)"
FT /evidence="ECO:0000305"
FT CONFLICT 336
FT /note="I -> S (in Ref. 3; AAH16456)"
FT /evidence="ECO:0000305"
FT STRAND 8..12
FT /evidence="ECO:0007829|PDB:1X1M"
FT STRAND 21..23
FT /evidence="ECO:0007829|PDB:1X1M"
FT HELIX 40..50
FT /evidence="ECO:0007829|PDB:1X1M"
FT TURN 52..54
FT /evidence="ECO:0007829|PDB:1X1M"
FT STRAND 58..65
FT /evidence="ECO:0007829|PDB:1X1M"
FT HELIX 76..79
FT /evidence="ECO:0007829|PDB:1X1M"
FT STRAND 86..93
FT /evidence="ECO:0007829|PDB:1X1M"
SQ SEQUENCE 380 AA; 40433 MW; 6DE0834A61F25820 CRC64;
MSLSDWHLAV KLADQPLAPK SILQLPETEL GEYSLGGYSI SFLKQLIAGK LQESVPDPEL
IDLIYCGRKL KDDQTLDFYG IQPGSTVHVL RKSWPEPDQK PEPVDKVAAL REFRVLHTAL
HSSSSYREAV FKMLSNKESL DQIIVATPGL SSDPIALGVL QDKDLFSVFA DPNMLDTLVP
AHPALVNAII LVLHSVAGST PMPGADSSSR SMPSSSYRDM PGGFLFDGLS DDEDDFHPST
RSTPSSSTPS SRPASLGYSG AAGPRPITQS ELATALALAS TPESSSHTPT PGTQGHSSGT
SPMSSGVQSG TPITNDLFSQ ALQHALQASG QPSLQIQWQP QLQQLRDMGI QDDELSLRAL
QATGGDIQAA LELIFAGGAP
