ID   UBLA_STRUB              Reviewed;          76 AA.
AC   A5H1G9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Bacteriocin uberolysin;
DE   Flags: Precursor;
GN   Name=ublA;
OS   Streptococcus uberis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1349;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND MASS SPECTROMETRY.
RX   PubMed=17464077; DOI=10.1099/mic.0.2006/005967-0;
RA   Wirawan R.E., Swanson K.M., Kleffmann T., Jack R.W., Tagg J.R.;
RT   "Uberolysin: a novel cyclic bacteriocin produced by Streptococcus uberis.";
RL   Microbiology 153:1619-1630(2007).
CC   -!- FUNCTION: Cyclopeptide antibiotic with bacteriolytic activity against
CC       most streptococci (except S.rattus and S.mutans), Listeria spp.,
CC       enterococci and staphylococci. {ECO:0000269|PubMed:17464077}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=7047.97; Mass_error=0.09; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:17464077};
CC   -!- MASS SPECTROMETRY: Mass=7043.94; Method=MALDI; Note=Monoisotopic mass.;
CC       Evidence={ECO:0000269|PubMed:17464077};
CC   -!- SIMILARITY: Belongs to the bacteriocin class V family. {ECO:0000305}.
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DR   EMBL; DQ650653; ABG48503.1; -; Genomic_DNA.
DR   RefSeq; WP_012657601.1; NZ_WUBX01000003.1.
DR   AlphaFoldDB; A5H1G9; -.
DR   SMR; A5H1G9; -.
DR   TCDB; 1.C.90.1.3; the carnocyclin a (carnocyclin) family.
DR   GeneID; 58022494; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.225.10; -; 1.
DR   InterPro; IPR009086; Bacteriocin_AS48.
DR   InterPro; IPR020038; Circ_bacteriocin.
DR   Pfam; PF09221; Bacteriocin_IId; 1.
DR   TIGRFAMs; TIGR03651; circ_ocin_uber; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Secreted.
FT   PROPEP          1..6
FT                   /id="PRO_0000326412"
FT   PEPTIDE         7..76
FT                   /note="Bacteriocin uberolysin"
FT                   /id="PRO_0000326413"
FT   CROSSLNK        7..76
FT                   /note="Cyclopeptide (Leu-Trp)"
SQ   SEQUENCE   76 AA;  7781 MW;  BEED2156D42A9155 CRC64;
     MDILLELAGY TGIASGTAKK VVDAIDKGAA AFVIISIIST VISAGALGAV SASADFIILT
     VKNYISRNLK AQAVIW