UBN1_ARATH
ID UBN1_ARATH Reviewed; 684 AA.
AC Q8RX78; Q9XI18;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Ubinuclein-1 {ECO:0000303|PubMed:25086063};
DE Short=AtUBN1 {ECO:0000303|PubMed:25086063};
DE AltName: Full=Ubiquitously expressed nuclear protein 1 {ECO:0000303|PubMed:25086063};
GN Name=UBN1 {ECO:0000303|PubMed:25086063};
GN OrderedLocusNames=At1g21610 {ECO:0000312|Araport:AT1G21610};
GN ORFNames=F24J8.24 {ECO:0000312|EMBL:AC015447},
GN F8K7.2 {ECO:0000312|EMBL:AAD41413.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH HIRA,
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=25086063; DOI=10.1242/bio.20148680;
RA Nie X., Wang H., Li J., Holec S., Berger F.;
RT "The HIRA complex that deposits the histone H3.3 is conserved in
RT Arabidopsis and facilitates transcriptional dynamics.";
RL Biol. Open 3:794-802(2014).
RN [5]
RP SUBUNIT, AND GENE FAMILY.
RX PubMed=25600486; DOI=10.1111/tpj.12758;
RA Duc C., Benoit M., Le Goff S., Simon L., Poulet A., Cotterell S.,
RA Tatout C., Probst A.V.;
RT "The histone chaperone complex HIR maintains nucleosome occupancy and
RT counterbalances impaired histone deposition in CAF-1 complex mutants.";
RL Plant J. 81:707-722(2015).
CC -!- FUNCTION: May be required for replication-independent chromatin
CC assembly. {ECO:0000250|UniProtKB:Q9NPG3}.
CC -!- SUBUNIT: Component of the HIRA complex made of UBN1, UBN2, ASF1A,
CC CABIN1 and HIRA (PubMed:25086063, PubMed:25600486). Interacts with HIRA
CC (PubMed:25086063). {ECO:0000269|PubMed:25086063,
CC ECO:0000269|PubMed:25600486}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25086063}. Nucleus,
CC nucleolus {ECO:0000269|PubMed:25086063}. Note=Localized at rDNA loci in
CC the nucleolus. {ECO:0000269|PubMed:25086063}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:25086063}.
CC -!- SIMILARITY: Belongs to the ubinuclein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD41413.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007727; AAD41413.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC015447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE30124.1; -; Genomic_DNA.
DR EMBL; AY090255; AAL90916.1; -; mRNA.
DR EMBL; AY125533; AAM78043.1; -; mRNA.
DR PIR; A86349; A86349.
DR RefSeq; NP_173580.2; NM_102010.5.
DR AlphaFoldDB; Q8RX78; -.
DR STRING; 3702.AT1G21610.3; -.
DR iPTMnet; Q8RX78; -.
DR PRIDE; Q8RX78; -.
DR EnsemblPlants; AT1G21610.1; AT1G21610.1; AT1G21610.
DR GeneID; 838762; -.
DR Gramene; AT1G21610.1; AT1G21610.1; AT1G21610.
DR KEGG; ath:AT1G21610; -.
DR Araport; AT1G21610; -.
DR eggNOG; ENOG502QRNW; Eukaryota.
DR OMA; EIKHDGF; -.
DR PhylomeDB; Q8RX78; -.
DR PRO; PR:Q8RX78; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8RX78; baseline and differential.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0030875; C:rDNA protrusion; IDA:UniProtKB.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR GO; GO:0045814; P:negative regulation of gene expression, epigenetic; IMP:UniProtKB.
DR GO; GO:0034728; P:nucleosome organization; IMP:UniProtKB.
DR GO; GO:0009651; P:response to salt stress; IMP:UniProtKB.
DR InterPro; IPR014840; HRD.
DR Pfam; PF08729; HUN; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator; Nucleus; Reference proteome.
FT CHAIN 1..684
FT /note="Ubinuclein-1"
FT /id="PRO_0000441876"
FT REGION 108..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..137
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 76330 MW; 22F5122720D8BC8A CRC64;
MSEVNEMSGG SIGGELLRAS PKVLTAGDRK LLKVELRPGD TTYVSWKKLM RDAGKVNGLS
ASVPDPPPNA NPNLEFRIAP GHPVEIETNE QPHSNRFNAV IEKIERLYKG NDSSDGEELD
GAPDDDEYDT EDSFIDDAEL DEYFEVDNST VKHDGFYVNR GKLERMEPST TSNQQPKKRR
RKDSAKPCRD AVDVSDKHTK LSITARKKDQ STAPGSWKTQ ESPLPSGAQD ANTSVPLDDV
KHSDRANHQS RNDTSHKSRE TGSSSALHQK YSNKSLHQQS TSLLGKSPPN VFAEVTVVRQ
KENNGMHQLA NVTGSRQSSQ ASKKDGSNVK SKTSILEKAI RELEKVVVES RPPAITENQE
ADTSSQAVKR RLPRDVKLKL AKVARIAQAS QGKHSTELIN RLMSIVGHLI QLRSLKRNLK
IMIDMGDSAT REKDTRFKQI NNEVLDMIKA KVSLMESQAI KPEGATSDDF QDSVEKPSLK
KFVMDAALED KLCDLYDIFI DGLDEDQGPQ TKKLYVNLAE LWPNRLMDYR GIKHAIFRAK
ERRKALYGNL AKEMDQTKMK KSMKQLVPRT DCTAQPNTEL VVQRQHSGEK KLIVDPNATS
TSVVTSQTMV DRSNQQQPEK LKGISSSCNP TEETRVVKRK NEAVMAEKQV VLALKKPEHP
QTRVIPAPQN LNIPRTTPDL NLPS
