UBN2_HUMAN
ID UBN2_HUMAN Reviewed; 1347 AA.
AC Q6ZU65; A4D1S2; Q2YDY4; Q6P1K0; Q86XN9; Q8N7D1;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Ubinuclein-2;
GN Name=UBN2; Synonyms=KIAA2030;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 75-1347 (ISOFORM 1), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 478-1347 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-1347 (ISOFORM 1).
RC TISSUE=Eye, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 325-1347 (ISOFORM 1).
RC TISSUE=Brain;
RA Nagase T., Kikuno R., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=19029251; DOI=10.1128/mcb.01047-08;
RA Banumathy G., Somaiah N., Zhang R., Tang Y., Hoffmann J., Andrake M.,
RA Ceulemans H., Schultz D., Marmorstein R., Adams P.D.;
RT "Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the
RT HIRA/ASF1a chromatin-remodeling pathway in senescent cells.";
RL Mol. Cell. Biol. 29:758-770(2009).
RN [9]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1148, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND SER-584, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND SER-584, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; THR-243; SER-311; SER-584
RP AND SER-1123, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-250 AND THR-252, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [14]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-272, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZU65-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZU65-2; Sequence=VSP_027021, VSP_027022;
CC -!- TISSUE SPECIFICITY: Expressed in several cell lines tested, including
CC primary and transformed cell lines. {ECO:0000269|PubMed:19029251}.
CC -!- SIMILARITY: Belongs to the ubinuclein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05362.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=EAL24038.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC009220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236950; EAL24038.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK098644; BAC05362.1; ALT_INIT; mRNA.
DR EMBL; AK125956; BAC86361.1; -; mRNA.
DR EMBL; BC065034; AAH65034.1; -; mRNA.
DR EMBL; BC108249; AAI08250.1; -; mRNA.
DR EMBL; AB107352; BAC67657.1; -; mRNA.
DR CCDS; CCDS43655.2; -. [Q6ZU65-1]
DR RefSeq; NP_775840.3; NM_173569.3. [Q6ZU65-1]
DR AlphaFoldDB; Q6ZU65; -.
DR BioGRID; 129009; 63.
DR DIP; DIP-47312N; -.
DR IntAct; Q6ZU65; 35.
DR MINT; Q6ZU65; -.
DR STRING; 9606.ENSP00000418648; -.
DR GlyGen; Q6ZU65; 7 sites, 1 O-linked glycan (7 sites).
DR iPTMnet; Q6ZU65; -.
DR PhosphoSitePlus; Q6ZU65; -.
DR BioMuta; UBN2; -.
DR DMDM; 156630841; -.
DR EPD; Q6ZU65; -.
DR jPOST; Q6ZU65; -.
DR MassIVE; Q6ZU65; -.
DR MaxQB; Q6ZU65; -.
DR PaxDb; Q6ZU65; -.
DR PeptideAtlas; Q6ZU65; -.
DR PRIDE; Q6ZU65; -.
DR ProteomicsDB; 68313; -. [Q6ZU65-1]
DR ProteomicsDB; 68314; -. [Q6ZU65-2]
DR Antibodypedia; 9881; 89 antibodies from 20 providers.
DR DNASU; 254048; -.
DR Ensembl; ENST00000473989.8; ENSP00000418648.2; ENSG00000157741.15. [Q6ZU65-1]
DR GeneID; 254048; -.
DR KEGG; hsa:254048; -.
DR MANE-Select; ENST00000473989.8; ENSP00000418648.2; NM_173569.4; NP_775840.3.
DR UCSC; uc011kqr.2; human. [Q6ZU65-1]
DR CTD; 254048; -.
DR GeneCards; UBN2; -.
DR HGNC; HGNC:21931; UBN2.
DR HPA; ENSG00000157741; Low tissue specificity.
DR MIM; 613841; gene.
DR neXtProt; NX_Q6ZU65; -.
DR OpenTargets; ENSG00000157741; -.
DR PharmGKB; PA164727415; -.
DR VEuPathDB; HostDB:ENSG00000157741; -.
DR eggNOG; KOG4786; Eukaryota.
DR GeneTree; ENSGT00940000155858; -.
DR HOGENOM; CLU_007400_1_0_1; -.
DR InParanoid; Q6ZU65; -.
DR OMA; RSRDMCG; -.
DR OrthoDB; 469344at2759; -.
DR PhylomeDB; Q6ZU65; -.
DR TreeFam; TF326088; -.
DR PathwayCommons; Q6ZU65; -.
DR SignaLink; Q6ZU65; -.
DR BioGRID-ORCS; 254048; 13 hits in 1080 CRISPR screens.
DR ChiTaRS; UBN2; human.
DR GenomeRNAi; 254048; -.
DR Pharos; Q6ZU65; Tbio.
DR PRO; PR:Q6ZU65; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q6ZU65; protein.
DR Bgee; ENSG00000157741; Expressed in upper arm skin and 191 other tissues.
DR ExpressionAtlas; Q6ZU65; baseline and differential.
DR Genevisible; Q6ZU65; HS.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR InterPro; IPR014840; HRD.
DR InterPro; IPR026943; Ubinuclein-2.
DR InterPro; IPR026947; UBN_middle_dom.
DR PANTHER; PTHR21669:SF10; PTHR21669:SF10; 1.
DR Pfam; PF08729; HUN; 1.
DR Pfam; PF14075; UBN_AB; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Isopeptide bond; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..1347
FT /note="Ubinuclein-2"
FT /id="PRO_0000295725"
FT REGION 1..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..66
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..116
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1062
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 13
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 243
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 250
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 252
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 311
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 416
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80WC1"
FT MOD_RES 419
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80WC1"
FT MOD_RES 422
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80WC1"
FT MOD_RES 584
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"
FT MOD_RES 1068
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q80WC1"
FT MOD_RES 1123
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1148
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:19608861"
FT CROSSLNK 272
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 958..970
FT /note="LSNNPQLSCSSSL -> GPCLRDVSEQFGP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027021"
FT VAR_SEQ 971..1347
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027022"
FT VARIANT 1308
FT /note="P -> A (in dbSNP:rs17160850)"
FT /id="VAR_033347"
SQ SEQUENCE 1347 AA; 146089 MW; 6B52672B860B18B5 CRC64;
MAEPRRVAFI SLSPVRRREA EYPGPEREPE YPREPPRLEP QPYREPARAE PPAPREPAPR
SDAQPPSREK PLPQREVSRA EPPMSLQREP PRPEPPPPFP PLPLQPPPPR ESASRAEQPP
RPPRETVRLE LVLKDPTDES CVEFSYPELL LCGEQRKKLI HTEDPFNDEH QERQEVEMLA
KKFEMKYGGK PRKHRKDRLQ DLIDIGFGYD ETDPFIDNSE AYDELVPASL TTKYGGFYIN
TGTLQFRQAS DTEEDDITDN QKHKPPKVPK IKEDDIEMKK RKRKEEGEKE KKPRKKVPKQ
LGVVALNSHK SEKKKKRYKD SLSLAAMIRK FQKEKDALKK ESNPKVPVTL STPSLNKPPC
AAAALGNDVP DLNLSSGDPD LPIFVSTNEH ELFQEAENAL EMLDDFDFDR LLDAASDGSP
LSESGGENGT TTQPTYTSQV MPKVVPTLPE GLPVLLEKRI EDLRVAAKLF DEEGRKKFFT
QDMNNILLDI ELQLQELGPV IRSGVYSHLE AFVPCNKETL VKRLKKLHLN VQDDRLREPL
QKLKLAVSNV MPEQLFKYQE DCQARSQAKC AKLQTDEERE KNGSEEDDDE KPGKRVIGPR
KKFHWDDTIR TLLCNLVEIK LGCYELEPNK SQSAEDYLKS FMETEVKPLW PKGWMQARML
FKESRSVHNH LTSAPAKKKV IPAPKPKVKE VMVKTLPLHS FPTMLKECSP KKDQKTPTSL
VASVSGPPTS SSTAAIAAAS SSSAPAQETI CLDDSLDEDL SFHSPSLDLV SEALAVINNG
NKGPPVGSRI SMPTTKPRPG LREEKLASIM SKLPLATPKK LDSTQTTHSS SLIAGHTGPV
PKKPQDLAHT GISSGLIAGS SIQNPKVSLE PLPARLLQQG LQRSSQIHTS SSSQTHVSSS
SQAQIAASSH ALGTSEAQDA SSLTQVTKVH QHSAVQQNYV SPLQATISKS QTNPVVKLSN
NPQLSCSSSL IKTSDKPLMY RLPLSTPSPG NGSQGSHPLV SRTVPSTTTS SNYLAKAMVS
QISTQGFKSP FSMAASPKLA ASPKPATSPK PLPSPKPSAS PKPSLSAKPS VSTKLISKSN
PTPKPTVSPS SSSPNALVAQ GSHSSTNSPV HKQPSGMNIS RQSPTLNLLP SSRTSGLPPT
KNLQAPSKLT NSSSTGTVGK NSLSGIAMNV PASRGSNLNS SGANRTSLSG GTGSGTQGAT
KPLSTPHRPS TASGSSVVTA SVQSTAGASL LANASPLTLM TSPLSVTNQN VTPFGMLGGL
VPVTMPFQFP LEIFGFGTDT AGVTTTSGST SAAFHHSLTQ NLLKGLQPGG AQHAATLSHS
PLPAHLQQAF HDGGQSKGDT KLPRKSQ
