UBN2_MOUSE
ID UBN2_MOUSE Reviewed; 1314 AA.
AC Q80WC1; Q69Z27; Q80ZZ9; Q8BQ40; Q8BRI2;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Ubinuclein-2;
GN Name=Ubn2; Synonyms=Kiaa2030;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 169-1313 (ISOFORM 3).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-1313 (ISOFORM 4), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 883-1313 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain, Brain cortex, and Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 676-1314 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-402; SER-405 AND
RP SER-408, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1036, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q80WC1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80WC1-2; Sequence=VSP_027026, VSP_027029;
CC Name=3;
CC IsoId=Q80WC1-3; Sequence=VSP_027023, VSP_027025, VSP_027027,
CC VSP_027028;
CC Name=4;
CC IsoId=Q80WC1-4; Sequence=VSP_027024;
CC -!- SIMILARITY: Belongs to the ubinuclein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC31801.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC043095; AAH43095.1; -; mRNA.
DR EMBL; BC051458; AAH51458.1; -; mRNA.
DR EMBL; AK044162; BAC31801.1; ALT_INIT; mRNA.
DR EMBL; AK051609; BAC34690.1; -; mRNA.
DR EMBL; AK173339; BAD32617.1; -; mRNA.
DR CCDS; CCDS39461.1; -. [Q80WC1-1]
DR RefSeq; NP_796159.3; NM_177185.4. [Q80WC1-1]
DR AlphaFoldDB; Q80WC1; -.
DR SMR; Q80WC1; -.
DR BioGRID; 236097; 4.
DR IntAct; Q80WC1; 2.
DR STRING; 10090.ENSMUSP00000036188; -.
DR iPTMnet; Q80WC1; -.
DR PhosphoSitePlus; Q80WC1; -.
DR EPD; Q80WC1; -.
DR jPOST; Q80WC1; -.
DR MaxQB; Q80WC1; -.
DR PaxDb; Q80WC1; -.
DR PeptideAtlas; Q80WC1; -.
DR PRIDE; Q80WC1; -.
DR ProteomicsDB; 297696; -. [Q80WC1-1]
DR ProteomicsDB; 297697; -. [Q80WC1-2]
DR ProteomicsDB; 297698; -. [Q80WC1-3]
DR ProteomicsDB; 297699; -. [Q80WC1-4]
DR Antibodypedia; 9881; 89 antibodies from 20 providers.
DR DNASU; 320538; -.
DR Ensembl; ENSMUST00000039127; ENSMUSP00000036188; ENSMUSG00000038538. [Q80WC1-4]
DR Ensembl; ENSMUST00000160583; ENSMUSP00000124043; ENSMUSG00000038538. [Q80WC1-1]
DR GeneID; 320538; -.
DR KEGG; mmu:320538; -.
DR UCSC; uc009bke.2; mouse. [Q80WC1-1]
DR UCSC; uc009bkh.2; mouse. [Q80WC1-4]
DR CTD; 254048; -.
DR MGI; MGI:2444236; Ubn2.
DR VEuPathDB; HostDB:ENSMUSG00000038538; -.
DR eggNOG; KOG4786; Eukaryota.
DR GeneTree; ENSGT00940000155858; -.
DR HOGENOM; CLU_007400_1_0_1; -.
DR InParanoid; Q80WC1; -.
DR OMA; RSRDMCG; -.
DR OrthoDB; 469344at2759; -.
DR PhylomeDB; Q80WC1; -.
DR TreeFam; TF326088; -.
DR BioGRID-ORCS; 320538; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Ubn2; mouse.
DR PRO; PR:Q80WC1; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q80WC1; protein.
DR Bgee; ENSMUSG00000038538; Expressed in rostral migratory stream and 224 other tissues.
DR ExpressionAtlas; Q80WC1; baseline and differential.
DR Genevisible; Q80WC1; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR InterPro; IPR014840; HRD.
DR InterPro; IPR026943; Ubinuclein-2.
DR InterPro; IPR026947; UBN_middle_dom.
DR PANTHER; PTHR21669:SF10; PTHR21669:SF10; 1.
DR Pfam; PF08729; HUN; 1.
DR Pfam; PF14075; UBN_AB; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Isopeptide bond; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..1314
FT /note="Ubinuclein-2"
FT /id="PRO_0000295726"
FT REGION 1..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1003..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..102
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..975
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1030
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 13
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 229
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
FT MOD_RES 236
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
FT MOD_RES 238
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
FT MOD_RES 297
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
FT MOD_RES 402
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 405
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 408
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 570
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
FT MOD_RES 1036
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 1091
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
FT MOD_RES 1116
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
FT CROSSLNK 258
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
FT VAR_SEQ 297..298
FT /note="SE -> K (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027023"
FT VAR_SEQ 451
FT /note="V -> VVS (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027024"
FT VAR_SEQ 674
FT /note="V -> VKAVLVKTLPVRSFPTML (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027025"
FT VAR_SEQ 1192..1203
FT /note="STAGASLLANAS -> FYQKPQRLRTKQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027026"
FT VAR_SEQ 1192..1194
FT /note="STA -> PSS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027027"
FT VAR_SEQ 1195..1314
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027028"
FT VAR_SEQ 1204..1314
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027029"
FT CONFLICT 284
FT /note="P -> S (in Ref. 2; BAC34690)"
FT /evidence="ECO:0000305"
FT CONFLICT 867
FT /note="Missing (in Ref. 1; AAH51458)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1314 AA; 141740 MW; 59CE63A74EE149E5 CRC64;
MAEPRRVAFI SLSPVRRREA DFAGAEREPP RLEPQPYREP ARAEPAPRAD AQPPARDKPL
PQREVSRAEP PMALQREPPR PEPPPPPLPL QTPPPRESAS RAEPPPRPPK ETVRLELVLK
DPTDESCVEF SYPELLLCGE QRKKLVHTED PFTDEHKERQ EVEMLAKKFE MKYGGKARKH
RKDRLQDLID IGFGYDETDP FIDNSEAYDE LVPASLTTKY GGFYINTGTL QFRQASDTEE
DDFTDNQKHK PPKVPKIKED DIEVKKRKRK EEGEKEKKPR KKVPKQLGVV ALNSHKSEKK
KKRYKDSLSL AAMIRKFQKE KDALKKESTP KVPVTPSSSS LPKPPCVTTA LGDDIPDLGL
NSADPDLPIF VSTNEHELFQ EAENALEMLD DFDFDRLLDA TSDGSPLSES GGENGNTTHP
TFPSQVVPKV VPTLPEGLPV LLEKRIEDLR VAAKLFDEEG RKKFFTQDMN NILLDIELQL
QELGPVIRSG VYSHLEAFVP CNKETLVKRL KKLHLNVQDD RLREPLQKLK LAVSNVMPEQ
LFKYQEDCQA RSQAKCAKLQ ADEEREKNGS DDDDDEKPGK RVIGPRKKFH WDDTIRTLLC
NLVEIKLGCY ELEPNKSQSA EDYLKSFMET EVKPLWPKGW MQARMLFKES RSVHNHLTSA
PAKKKVIPAS KPKVKECSPK KDPKAPASVV ASGGGPSTSS STSIVASASS SSAPAQETIC
LDDSLDEDLS FPSASLDLVS EALAVINNGN KGPSVGSRLN VPTTKPRPGL REEKLASIMS
KLPLATPKKL DSTQTAHSSS LIAGHTGPVP KKPQDLAHTG ISSGLIAGSS IQNPKVSLEP
LPARLLQQGL QRSSQIHASS SSQTHVSSSQ AQAAASSHAL GTSEAQDASS LTQVTKVHQH
SAVQQNYVSP LQATISKSQT NPVVKLSNNP QLSCSSQLLK TSDKPLMYRL PLSTPSPGNG
SQGPHPLVSR TAPSTTTSSN YLAKAMVSQI STQGFKSPFS MAASPKLAAS PKPATSPKPL
PSPKPSVSPK PSLSAKPSIS TKQISKSNPA PKPAVCPSSS SPNTLVAQSS HSTSNNPVHK
QPSGMNISRQ SPTLNLLPSN RTSGLPTTKT LQAPSKLTNS SSTGTAGKNS LSGIPMNVPA
SRGSNLNSSG ANRTSLSGGT GSGTQGATKP LSTPHRPTSA SGSSVVTASV QSTAGASLLA
NASPLTLMTS PLSVTNQTVT PFGMLGGLVP VTMPFQFPLE LLGFGTDTAG VTATSGSTSA
ALHHSLTQNL LKSLQPGAQH AAALPHSPLP AHLQQAFNDG GQSKGDTKLP RKPQ
