UBN2_RAT
ID UBN2_RAT Reviewed; 1330 AA.
AC D4A666;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Ubinuclein-2;
GN Name=Ubn2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-236 AND THR-238, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- SIMILARITY: Belongs to the ubinuclein family. {ECO:0000305}.
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DR EMBL; CH473959; EDM15360.1; -; Genomic_DNA.
DR RefSeq; NP_001128025.1; NM_001134553.1.
DR AlphaFoldDB; D4A666; -.
DR SMR; D4A666; -.
DR STRING; 10116.ENSRNOP00000061860; -.
DR iPTMnet; D4A666; -.
DR PhosphoSitePlus; D4A666; -.
DR PaxDb; D4A666; -.
DR PeptideAtlas; D4A666; -.
DR PRIDE; D4A666; -.
DR GeneID; 312248; -.
DR KEGG; rno:312248; -.
DR UCSC; RGD:1310722; rat.
DR CTD; 254048; -.
DR RGD; 1310722; Ubn2.
DR VEuPathDB; HostDB:ENSRNOG00000005564; -.
DR eggNOG; KOG4786; Eukaryota.
DR HOGENOM; CLU_007400_1_0_1; -.
DR InParanoid; D4A666; -.
DR OMA; RSRDMCG; -.
DR OrthoDB; 469344at2759; -.
DR PhylomeDB; D4A666; -.
DR TreeFam; TF326088; -.
DR PRO; PR:D4A666; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Proteomes; UP000234681; Chromosome 4.
DR Bgee; ENSRNOG00000005564; Expressed in testis and 19 other tissues.
DR Genevisible; D4A666; RN.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR InterPro; IPR014840; HRD.
DR InterPro; IPR026943; Ubinuclein-2.
DR InterPro; IPR026947; UBN_middle_dom.
DR PANTHER; PTHR21669:SF10; PTHR21669:SF10; 1.
DR Pfam; PF08729; HUN; 1.
DR Pfam; PF14075; UBN_AB; 1.
PE 1: Evidence at protein level;
KW Acetylation; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..1330
FT /note="Ubinuclein-2"
FT /id="PRO_0000403362"
FT REGION 1..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 964..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1292..1330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..102
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1292..1318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 13
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 229
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
FT MOD_RES 236
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 238
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 297
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
FT MOD_RES 402
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80WC1"
FT MOD_RES 405
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80WC1"
FT MOD_RES 408
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80WC1"
FT MOD_RES 570
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
FT MOD_RES 1052
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q80WC1"
FT MOD_RES 1107
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
FT MOD_RES 1132
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
FT CROSSLNK 258
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6ZU65"
SQ SEQUENCE 1330 AA; 143640 MW; 3EE5D940AB90CA7B CRC64;
MAEPRRVAFI SLSPVRRREA DFAGAEREPP RLEPQPYREP ARAEPAPRAD AQPPARDKPL
PQREVSRAEP PMALQREPPR PEPPPPPLPL QTPPPRESAS RAEPPPRPPK ETVRLELVLK
DPTDESCVEF SYPELLLCGE QRKKLVHTED PFTDEHKERQ EVEMLAKKFE MKYGGKARKH
RKDRLQDLID IGFGYDETDP FIDNSEAYDE LVPASLTTKY GGFYINTGTL QFRQASDTEE
DDFTDNQKHK PPKVPKIKDD DIEAKKRKRK EEGEKEKKPR KKVPKQLGVV ALNSHKSEKK
KKRYKDSLSL AAMIRKFQKE KDALKKESTP KVPVIPSTSS LPKPPCAATT LGDDIPDLSL
NSADPDLPIF VSTNEHELFQ EAENALEMLD DFDFDRLLDA TSDGSPLSES GGENGNTTQP
TFASQVVPKV VPTLPDGLPV LLEKRIEDLR VAAKLFDEEG RKKFFTQDMN NILLDIELQL
QELGPVIRSG VYSHLEAFVP CNKETLVKRL KKLHLNVQDD RLREPLQKLK LAVSNVMPEQ
LFKYQEDCQA RSQAKCAKLQ ADEEREKNGS DDDDDEKPGK RVIGPRKKFH WDDTIRTLLC
NLVEIKLGCY ELEPNKSQSA EDYLKSFMET EVKPLWPKGW MQARMLFKES RSVHNHLTSA
PAKKKVIPAS KPKVKEVMVK TLPVRSFPTM LKECSPKKDP KAPASVVASG GCPCTSSSTS
IVASASSSST PAQETICLDD SLDEDLSLPS ASLDLVSEAL AVINNGNKGP SVSSRLNVPT
TKPRPGLREE KLASIMSKLP LATPKKLDSP QTAHSSSLIA GHTGPVPKKP QDLAHTGISS
GLIAGSSIQN PKVSLEPLPA RLLQQGLQRS SQIHASSSQT HVSSSQAQAA ASSHALGTSE
AQDASSLTQV TKVHQHSAVQ QNYVSPLQAT ISKSQTNPVV KLSNNPQLSC SSQLLKTSEK
PLMYRLPLST PSPGNGSQGS HPLVSRTAPS TTTSSNYLAK AMVSQISTQG FKSPFSMAAS
PKLAASPKPA TSPKPLTSPK PSVSPKPSLS AKPSVSTKLI SKSNPTPKPA VCPSSSSPNT
LVAQSSHSTS NNPAHKQPSG MNISRQSPTL NLLPSNRTSG LPTTKTLQAP SKLTNSSSAG
TVGKNSLSGI PVNVPASRGS NLNSSGANRT SLSGGTGSGT QGATKPLSTP HRPTSASGSS
VVTASVQSTA GASLLANASP LTLMTSPLSV TNQTVTPFGM LGGLVPVTMP FQFPLELLGF
GTDTAGVTAT SGSTSAALHH GLTQNLLKSL QPGTQHAATL PHSPLPTHLQ QAFNDGGQSK
GDTKLPRKPQ
