ID   UBP18_PONAB             Reviewed;         375 AA.
AC   Q5RE63;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Ubl carboxyl-terminal hydrolase 18;
DE            EC=3.4.19.-;
DE   AltName: Full=ISG15-specific-processing protease;
DE   AltName: Full=Ubl thioesterase 18;
GN   Name=USP18;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the regulation of inflammatory response to
CC       interferon type 1. Can efficiently cleave only ISG15 fusions including
CC       native ISG15 conjugates linked via isopeptide bonds. Necessary to
CC       maintain a critical cellular balance of ISG15-conjugated proteins in
CC       both healthy and stressed organisms. {ECO:0000250|UniProtKB:Q9UMW8}.
CC   -!- SIMILARITY: Belongs to the peptidase C19 family. {ECO:0000305}.
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DR   EMBL; CR857674; CAH89944.1; -; mRNA.
DR   RefSeq; NP_001124911.1; NM_001131439.1.
DR   AlphaFoldDB; Q5RE63; -.
DR   SMR; Q5RE63; -.
DR   STRING; 9601.ENSPPYP00000022342; -.
DR   MEROPS; C19.030; -.
DR   GeneID; 100171781; -.
DR   KEGG; pon:100171781; -.
DR   CTD; 11274; -.
DR   eggNOG; KOG1863; Eukaryota.
DR   InParanoid; Q5RE63; -.
DR   OrthoDB; 147564at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0016579; P:protein deubiquitination; IEA:InterPro.
DR   GO; GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   Pfam; PF00443; UCH; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Ubl conjugation pathway.
FT   CHAIN           1..375
FT                   /note="Ubl carboxyl-terminal hydrolase 18"
FT                   /id="PRO_0000312415"
FT   DOMAIN          55..373
FT                   /note="USP"
FT   REGION          18..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        64
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10092,
FT                   ECO:0000255|PROSITE-ProRule:PRU10093"
FT   ACT_SITE        321
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10092,
FT                   ECO:0000255|PROSITE-ProRule:PRU10093"
SQ   SEQUENCE   375 AA;  43521 MW;  61B9698177C6CE5B CRC64;
     MSKAFGLLRQ TCQSILAESP QSPADLEEKK EEDSNMKREQ PRERPRAWDY PHGLVGLHNI
     GQTCCLNSLI QVFVMNVDFA RILKRITVPR GADEQRRSVP FQMLLLLEKM QDSRQKAVRP
     LELAYCLQKY NVPLFVQHDA AQLYLKLWNL MKDQITDVHL VERLQALYMI RMKDSLICLD
     CAMESSRNSS MLTLPLSLFD VDSKPLKTLV GQEDALHCFF QPRELSRKSK CFCENCGKKT
     HRKQVLKLTH FPQTLTIHLM RFSIRNSQTR KICHSLYFPQ SLDFSQVLPT KQKSCDAEEQ
     PGGQFELFAV IAHVGMADSG HYCVYIRNAV DGKWFCFNDS NICLVSWEDI QCTYGNPNYH
     WQETAYLLVY MKMEC