ID   C99L2_BOVIN             Reviewed;         217 AA.
AC   A1A4K1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=CD99 antigen-like protein 2;
DE   AltName: CD_antigen=CD99;
DE   Flags: Precursor;
GN   Name=CD99L2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in a late step of leukocyte extravasation
CC       helping cells to overcome the endothelial basement membrane. Acts at
CC       the same site as, but independently of, PECAM1 (By similarity).
CC       Homophilic adhesion molecule, but these interactions may not be
CC       required for cell aggregation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell
CC       junction {ECO:0000250}.
CC   -!- PTM: O-glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CD99 family. {ECO:0000305}.
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DR   EMBL; BC126619; AAI26620.1; -; mRNA.
DR   RefSeq; NP_001077227.1; NM_001083758.1.
DR   AlphaFoldDB; A1A4K1; -.
DR   STRING; 9913.ENSBTAP00000054220; -.
DR   PaxDb; A1A4K1; -.
DR   PRIDE; A1A4K1; -.
DR   Ensembl; ENSBTAT00000070875; ENSBTAP00000069370; ENSBTAG00000052670.
DR   GeneID; 613644; -.
DR   KEGG; bta:613644; -.
DR   CTD; 83692; -.
DR   VEuPathDB; HostDB:ENSBTAG00000052670; -.
DR   VGNC; VGNC:106678; CD99L2.
DR   eggNOG; ENOG502RZ6C; Eukaryota.
DR   GeneTree; ENSGT00940000154344; -.
DR   HOGENOM; CLU_2378281_0_0_1; -.
DR   InParanoid; A1A4K1; -.
DR   OMA; EDIAWGG; -.
DR   OrthoDB; 1559463at2759; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000052670; Expressed in hypothalamus and 105 other tissues.
DR   ExpressionAtlas; A1A4K1; baseline.
DR   GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0050904; P:diapedesis; IEA:Ensembl.
DR   GO; GO:2000391; P:positive regulation of neutrophil extravasation; IEA:Ensembl.
DR   GO; GO:2000409; P:positive regulation of T cell extravasation; IEA:Ensembl.
DR   InterPro; IPR022078; CD99L2.
DR   PANTHER; PTHR15076; PTHR15076; 2.
DR   Pfam; PF12301; CD99L2; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cell junction; Cell membrane; Glycoprotein; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..217
FT                   /note="CD99 antigen-like protein 2"
FT                   /id="PRO_0000340091"
FT   TOPO_DOM        26..141
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..217
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          36..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..57
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..97
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   217 AA;  22987 MW;  0B4A59BE1477AA93 CRC64;
     MVAWRWACLI CLAFSLTTLV QRGSGDTGGF RLEDAVEGTS SVKQRWDHVT TTTRRPGATR
     APAKPAGPPA EDDFNLADAL DDQNDRDHDR KKPSIGGGGF SDKDLEDIVG GGDYKPDKGK
     GGGQYGGGDN SDDSGMSAET GTIAGVASAL AMALIGAVSS YISYQQKKFC FSIQQGLNAD
     YVKGENLEAV VCEEPQVKYS ALQTQSTEPP PPEPPRI