ID   C99L2_DANRE             Reviewed;         252 AA.
AC   Q6DBW9; Q8QFW9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=CD99 antigen-like protein 2;
DE   AltName: CD_antigen=CD99;
DE   Flags: Precursor;
GN   Name=cd99l2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND DEVELOPMENTAL STAGE.
RX   PubMed=12706889; DOI=10.1016/s0378-1119(03)00401-3;
RA   Suh Y.H., Shin Y.K., Kook M.-C., Oh K.I., Park W.S., Kim S.H., Lee I.-S.,
RA   Park H.J., Huh T.-L., Park S.H.;
RT   "Cloning, genomic organization, alternative transcripts and expression
RT   analysis of CD99L2, a novel paralog of human CD99, and identification of
RT   evolutionary conserved motifs.";
RL   Gene 307:63-76(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a homophilic adhesion molecule.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell
CC       junction {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6DBW9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6DBW9-2; Sequence=VSP_034187;
CC   -!- DEVELOPMENTAL STAGE: Expressed in the dorsal region of the neural keel
CC       as somatogenesis proceeds before 25 hpf. At 25 hpf, expression is
CC       highest in the neural plate, in the brain including telencephalon,
CC       diencephalon, tectum and the rhombomere boundary. Highly expressed in
CC       lens, germinal ganglion, otic capsule and rhombomeres 2-7. Weakly
CC       expressed in trunk and tail. Expression is particularly high in otic
CC       capsule at 48 hpf. {ECO:0000269|PubMed:12706889}.
CC   -!- SIMILARITY: Belongs to the CD99 family. {ECO:0000305}.
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DR   EMBL; AY078168; AAL86620.1; -; mRNA.
DR   EMBL; BC078330; AAH78330.1; -; mRNA.
DR   RefSeq; NP_001315453.1; NM_001328524.1. [Q6DBW9-1]
DR   RefSeq; NP_919350.2; NM_194369.2. [Q6DBW9-2]
DR   AlphaFoldDB; Q6DBW9; -.
DR   STRING; 7955.ENSDARP00000073691; -.
DR   PRIDE; Q6DBW9; -.
DR   Ensembl; ENSDART00000079235; ENSDARP00000073691; ENSDARG00000056722. [Q6DBW9-1]
DR   Ensembl; ENSDART00000173505; ENSDARP00000142717; ENSDARG00000056722. [Q6DBW9-2]
DR   GeneID; 323266; -.
DR   KEGG; dre:323266; -.
DR   CTD; 83692; -.
DR   ZFIN; ZDB-GENE-030131-1986; cd99l2.
DR   GeneTree; ENSGT00940000154344; -.
DR   HOGENOM; CLU_092825_0_1_1; -.
DR   InParanoid; Q6DBW9; -.
DR   OMA; EDIAWGG; -.
DR   PhylomeDB; Q6DBW9; -.
DR   PRO; PR:Q6DBW9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000056722; Expressed in somite and 46 other tissues.
DR   ExpressionAtlas; Q6DBW9; baseline and differential.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   InterPro; IPR022078; CD99L2.
DR   PANTHER; PTHR15076; PTHR15076; 1.
DR   Pfam; PF12301; CD99L2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell adhesion; Cell junction; Cell membrane;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..252
FT                   /note="CD99 antigen-like protein 2"
FT                   /id="PRO_0000340096"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          30..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         109..125
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12706889"
FT                   /id="VSP_034187"
FT   CONFLICT        22
FT                   /note="M -> L (in Ref. 1; AAL86620)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   252 AA;  26102 MW;  7FB6A0A614D564E4 CRC64;
     MEKTLWTWTL LAVFSLLVVK GMSDGLDLAD ALGDDDDDEP TTKPPKADPG AGGAGGAAVK
     PTLKPVKPTV KEPAKPKPKQ TGLDDFDLAD ALNPDNDIKG KGKDSGKGDK EVGGGSRDDG
     TPNSRGSQFS DDDLLDVGND NSYKPDKGKG GKGGSSSNVG DLDPADDNNY DTMAETGTIA
     GIVSAVAMAL VGAVSSYISY QKKKLCFSIQ QSLNADMVKA DAPDAVVAQE PQVQQTLLQP
     PNAEPPTEEN AV