ID   C99L2_XENTR             Reviewed;         241 AA.
AC   B1H3G4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=CD99 antigen-like protein 2;
DE   AltName: CD_antigen=CD99;
DE   Flags: Precursor;
GN   Name=cd99l2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a homophilic adhesion molecule.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell
CC       junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CD99 family. {ECO:0000305}.
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DR   EMBL; BC161386; AAI61386.1; -; mRNA.
DR   RefSeq; NP_001120500.1; NM_001127028.1.
DR   AlphaFoldDB; B1H3G4; -.
DR   STRING; 8364.ENSXETP00000041895; -.
DR   PaxDb; B1H3G4; -.
DR   GeneID; 100145623; -.
DR   KEGG; xtr:100145623; -.
DR   CTD; 83692; -.
DR   Xenbase; XB-GENE-6458996; cd99l2.
DR   eggNOG; ENOG502RZ6C; Eukaryota.
DR   InParanoid; B1H3G4; -.
DR   OrthoDB; 1559463at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000011390; Expressed in skeletal muscle tissue and 15 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   InterPro; IPR022078; CD99L2.
DR   PANTHER; PTHR15076; PTHR15076; 1.
DR   Pfam; PF12301; CD99L2; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cell junction; Cell membrane; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..241
FT                   /note="CD99 antigen-like protein 2"
FT                   /id="PRO_0000340097"
FT   TOPO_DOM        24..173
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        197..241
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          30..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..59
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..136
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   241 AA;  25555 MW;  52932DE2E702A7B1 CRC64;
     MAKWGSPFVF ALACLALSWR VYGDDFDLYD ALGDPTEKPK PKPPKPPKSP THDSGDLDLS
     DFFDTPVKTT TKSPRLPPKQ PDLRFSTTTK KPRTTKIPPK KSDPNDFDLS DALDGNNGKG
     DISDSDLDDI LNDGYNPDKK KGGGGGGGGG GRATGQGDND GSDTGFGSQA ETGTIAGIAS
     ALAMALIGAV SSYISYQQKK FCFSIQEGLN AEYVKGEHME AVVSEEPQVK YSVVESQSAI
     P