ID   C9L_VACCC               Reviewed;         634 AA.
AC   P21042;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   23-FEB-2022, entry version 83.
DE   RecName: Full=Ankyrin repeat protein C9L;
GN   ORFNames=C9L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
CC   -!- FUNCTION: Plays a role in the inhibition of host immune repsonse by
CC       counteracting the action of interferons on early events in the viral
CC       replication cycle. {ECO:0000250|UniProtKB:P17372}.
CC   -!- SUBUNIT: Interacts with components of host SCF complex CUL1 and SKP1
CC       and components of the cullin deneddylation/COP9 signalosome complex
CC       subunits COPS7A and COPS7B. {ECO:0000250|UniProtKB:P17372}.
CC   -!- SIMILARITY: Belongs to the vaccinia virus protein C9L protein family.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA47988.1; -; Genomic_DNA.
DR   PIR; E42503; E42503.
DR   SMR; P21042; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR   SMART; SM00248; ANK; 7.
DR   SMART; SM00025; Pumilio; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat; Early protein; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Reference proteome;
KW   Repeat; Viral immunoevasion.
FT   CHAIN           1..634
FT                   /note="Ankyrin repeat protein C9L"
FT                   /id="PRO_0000067093"
FT   REPEAT          36..69
FT                   /note="ANK 1"
FT   REPEAT          70..100
FT                   /note="ANK 2"
FT   REPEAT          103..134
FT                   /note="ANK 3"
FT   REPEAT          175..211
FT                   /note="ANK 4"
FT   REPEAT          307..337
FT                   /note="ANK 5"
FT   REPEAT          412..441
FT                   /note="ANK 6"
SQ   SEQUENCE   634 AA;  74664 MW;  13E610406768FFB2 CRC64;
     MVNDKILYDS CKTFNIDASS AQSLIESGAN PLYEYDGETP LKAYVTKKNN NIKNDVVILL
     LSSVDYKNIN DFDIFEYLCS DNIDIDLLKL LISKGIEINS IKNGINIVEK YATTSNPNVD
     VFKLLLDKGI PTCSNIQYGY KIKIEQIRRA GEYYNWDDEL DDYDYDYTTD YDDRMGKTVL
     YYYIITRSQD GYATSLDVIN YLISHKKEMR YYTYREHTTL YYYLDKCDIK REIFDALFDS
     NYSGHELMNI LSNYLRKQFR KKNHKIDNYI VDQLLFDRDT FYILELCNSL RNNILISTIL
     KRYTVSIQDL LLEYVSYHTV YINVIKCMID EGATLYRFKH INKYFQKFGN RDPKVVEYIL
     KNGNLVVDND NDDNLINIMP LFPTFSMREL DVLSILKLCK PYIDDINKID KHGCSILYHC
     IKSHSVSLVE WLIDNGADIN IITKYGFTCI TICVILADKY IPEIAELYIK ILEIILSKLP
     TIECIKKTVD YLDDHRYLFI GGNNKSLLKI CIKYFILVDY KYTCSMYPSY IEFITDCEKE
     IADMRQIKIN GTDMLTVMYM LNKPTKKRYV NNPIFTDWAN KQYKFYNQII YNANKLIEQS
     KKIDDMIEEV SIDDNRLSTL PLEIRHLIFS YAFL