UBP54_HUMAN
ID UBP54_HUMAN Reviewed; 1684 AA.
AC Q70EL1; A1L4Q4; A3KFK3; A3KFK5; A3KFK6; A3KFK7; A6PVS4; A6PVS5; A6PVS6;
AC A6PVS7; B3KVY1; B9ZVM1; Q5F2F4; Q6P1N6; Q6ZSP1; Q6ZSR1; Q6ZTM0; Q8N1X2;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 4.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Inactive ubiquitin carboxyl-terminal hydrolase 54;
DE AltName: Full=Inactive ubiquitin-specific peptidase 54;
GN Name=USP54; Synonyms=C10orf29;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), LACK OF ENZYME ACTIVITY, AND TISSUE
RP SPECIFICITY.
RX PubMed=14715245; DOI=10.1016/j.bbrc.2003.12.050;
RA Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S.,
RA Lopez-Otin C.;
RT "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
RT proteases.";
RL Biochem. Biophys. Res. Commun. 314:54-62(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 6 AND 7).
RC TISSUE=Amygdala, Hippocampus, Lung, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Fetal liver;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-671, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-603 AND SER-632, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [9]
RP VARIANT [LARGE SCALE ANALYSIS] VAL-505.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Has no peptidase activity.
CC -!- INTERACTION:
CC Q70EL1; P54253: ATXN1; NbExp=3; IntAct=EBI-946185, EBI-930964;
CC Q70EL1; O60573: EIF4E2; NbExp=3; IntAct=EBI-946185, EBI-398610;
CC Q70EL1; Q9NPJ8: NXT2; NbExp=3; IntAct=EBI-946185, EBI-752122;
CC Q70EL1-9; X5D778: ANKRD11; NbExp=3; IntAct=EBI-11975223, EBI-17183751;
CC Q70EL1-9; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-11975223, EBI-11954519;
CC Q70EL1-9; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-11975223, EBI-742909;
CC Q70EL1-9; P54253: ATXN1; NbExp=6; IntAct=EBI-11975223, EBI-930964;
CC Q70EL1-9; P0C7T5: ATXN1L; NbExp=3; IntAct=EBI-11975223, EBI-8624731;
CC Q70EL1-9; Q13515: BFSP2; NbExp=3; IntAct=EBI-11975223, EBI-10229433;
CC Q70EL1-9; O14503: BHLHE40; NbExp=3; IntAct=EBI-11975223, EBI-711810;
CC Q70EL1-9; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-11975223, EBI-3866279;
CC Q70EL1-9; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-11975223, EBI-10961312;
CC Q70EL1-9; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-11975223, EBI-1104933;
CC Q70EL1-9; O75909-2: CCNK; NbExp=3; IntAct=EBI-11975223, EBI-12010594;
CC Q70EL1-9; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-11975223, EBI-396137;
CC Q70EL1-9; Q9Y6H1: CHCHD2; NbExp=3; IntAct=EBI-11975223, EBI-2321769;
CC Q70EL1-9; Q8IWX8: CHERP; NbExp=3; IntAct=EBI-11975223, EBI-2555370;
CC Q70EL1-9; P33240: CSTF2; NbExp=3; IntAct=EBI-11975223, EBI-711360;
CC Q70EL1-9; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11975223, EBI-3867333;
CC Q70EL1-9; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-11975223, EBI-9679045;
CC Q70EL1-9; G5E9A7: DMWD; NbExp=3; IntAct=EBI-11975223, EBI-10976677;
CC Q70EL1-9; Q6PKX4: DOK6; NbExp=3; IntAct=EBI-11975223, EBI-2880244;
CC Q70EL1-9; Q86UW9: DTX2; NbExp=3; IntAct=EBI-11975223, EBI-740376;
CC Q70EL1-9; Q7L775: EPM2AIP1; NbExp=3; IntAct=EBI-11975223, EBI-6255981;
CC Q70EL1-9; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-11975223, EBI-742102;
CC Q70EL1-9; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-11975223, EBI-11986315;
CC Q70EL1-9; Q96EF6: FBXO17; NbExp=3; IntAct=EBI-11975223, EBI-2510157;
CC Q70EL1-9; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-11975223, EBI-10242151;
CC Q70EL1-9; Q12951-2: FOXI1; NbExp=3; IntAct=EBI-11975223, EBI-12018822;
CC Q70EL1-9; O75603: GCM2; NbExp=3; IntAct=EBI-11975223, EBI-10188645;
CC Q70EL1-9; O14964: HGS; NbExp=3; IntAct=EBI-11975223, EBI-740220;
CC Q70EL1-9; P35680: HNF1B; NbExp=3; IntAct=EBI-11975223, EBI-2798841;
CC Q70EL1-9; P52597: HNRNPF; NbExp=3; IntAct=EBI-11975223, EBI-352986;
CC Q70EL1-9; P31273: HOXC8; NbExp=3; IntAct=EBI-11975223, EBI-1752118;
CC Q70EL1-9; Q86VF2-5: IGFN1; NbExp=3; IntAct=EBI-11975223, EBI-11955401;
CC Q70EL1-9; Q1MX18: INSC; NbExp=3; IntAct=EBI-11975223, EBI-12081118;
CC Q70EL1-9; Q7L273: KCTD9; NbExp=3; IntAct=EBI-11975223, EBI-4397613;
CC Q70EL1-9; P02545: LMNA; NbExp=3; IntAct=EBI-11975223, EBI-351935;
CC Q70EL1-9; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-11975223, EBI-11742507;
CC Q70EL1-9; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-11975223, EBI-739832;
CC Q70EL1-9; Q71SY5: MED25; NbExp=3; IntAct=EBI-11975223, EBI-394558;
CC Q70EL1-9; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-11975223, EBI-10172526;
CC Q70EL1-9; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-11975223, EBI-10297093;
CC Q70EL1-9; O43482: OIP5; NbExp=3; IntAct=EBI-11975223, EBI-536879;
CC Q70EL1-9; P32242: OTX1; NbExp=3; IntAct=EBI-11975223, EBI-740446;
CC Q70EL1-9; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-11975223, EBI-11956269;
CC Q70EL1-9; O43189: PHF1; NbExp=3; IntAct=EBI-11975223, EBI-530034;
CC Q70EL1-9; O60733: PLA2G6; NbExp=3; IntAct=EBI-11975223, EBI-12089905;
CC Q70EL1-9; Q494U1-3: PLEKHN1; NbExp=3; IntAct=EBI-11975223, EBI-12014286;
CC Q70EL1-9; O15160: POLR1C; NbExp=3; IntAct=EBI-11975223, EBI-1055079;
CC Q70EL1-9; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-11975223, EBI-11320284;
CC Q70EL1-9; O43741: PRKAB2; NbExp=3; IntAct=EBI-11975223, EBI-1053424;
CC Q70EL1-9; P0CG20: PRR35; NbExp=3; IntAct=EBI-11975223, EBI-11986293;
CC Q70EL1-9; Q2TAL8: QRICH1; NbExp=3; IntAct=EBI-11975223, EBI-2798044;
CC Q70EL1-9; P63244: RACK1; NbExp=3; IntAct=EBI-11975223, EBI-296739;
CC Q70EL1-9; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-11975223, EBI-744023;
CC Q70EL1-9; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-11975223, EBI-11987469;
CC Q70EL1-9; O94955: RHOBTB3; NbExp=3; IntAct=EBI-11975223, EBI-2367123;
CC Q70EL1-9; Q9H0X6: RNF208; NbExp=3; IntAct=EBI-11975223, EBI-751555;
CC Q70EL1-9; O95486-2: SEC24A; NbExp=3; IntAct=EBI-11975223, EBI-12320085;
CC Q70EL1-9; Q9H0F6-2: SHARPIN; NbExp=3; IntAct=EBI-11975223, EBI-9843813;
CC Q70EL1-9; Q92529: SHC3; NbExp=3; IntAct=EBI-11975223, EBI-79084;
CC Q70EL1-9; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-11975223, EBI-358489;
CC Q70EL1-9; Q8NB12: SMYD1; NbExp=3; IntAct=EBI-11975223, EBI-8463848;
CC Q70EL1-9; P14678-2: SNRPB; NbExp=3; IntAct=EBI-11975223, EBI-372475;
CC Q70EL1-9; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-11975223, EBI-5235340;
CC Q70EL1-9; O75177-5: SS18L1; NbExp=3; IntAct=EBI-11975223, EBI-12035119;
CC Q70EL1-9; O75716: STK16; NbExp=3; IntAct=EBI-11975223, EBI-749295;
CC Q70EL1-9; O95947: TBX6; NbExp=3; IntAct=EBI-11975223, EBI-2824328;
CC Q70EL1-9; Q15560: TCEA2; NbExp=3; IntAct=EBI-11975223, EBI-710310;
CC Q70EL1-9; Q96M29: TEKT5; NbExp=3; IntAct=EBI-11975223, EBI-10239812;
CC Q70EL1-9; Q96A09: TENT5B; NbExp=3; IntAct=EBI-11975223, EBI-752030;
CC Q70EL1-9; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-11975223, EBI-11952651;
CC Q70EL1-9; Q08117-2: TLE5; NbExp=3; IntAct=EBI-11975223, EBI-11741437;
CC Q70EL1-9; Q63HR2: TNS2; NbExp=3; IntAct=EBI-11975223, EBI-949753;
CC Q70EL1-9; Q9H0E2: TOLLIP; NbExp=3; IntAct=EBI-11975223, EBI-74615;
CC Q70EL1-9; Q86WV8: TSC1; NbExp=3; IntAct=EBI-11975223, EBI-12806590;
CC Q70EL1-9; Q8WW01: TSEN15; NbExp=3; IntAct=EBI-11975223, EBI-372432;
CC Q70EL1-9; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-11975223, EBI-3918381;
CC Q70EL1-9; Q6DKK2: TTC19; NbExp=3; IntAct=EBI-11975223, EBI-948354;
CC Q70EL1-9; O75604: USP2; NbExp=3; IntAct=EBI-11975223, EBI-743272;
CC Q70EL1-9; O95231: VENTX; NbExp=3; IntAct=EBI-11975223, EBI-10191303;
CC Q70EL1-9; Q8WYQ9: ZCCHC14; NbExp=3; IntAct=EBI-11975223, EBI-3937908;
CC Q70EL1-9; Q9UQR1-2: ZNF148; NbExp=3; IntAct=EBI-11975223, EBI-11742222;
CC Q70EL1-9; P36508: ZNF76; NbExp=3; IntAct=EBI-11975223, EBI-7254550;
CC Q70EL1-9; Q96EJ4; NbExp=3; IntAct=EBI-11975223, EBI-750454;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=1;
CC IsoId=Q70EL1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q70EL1-4; Sequence=VSP_026525, VSP_026526;
CC Name=3;
CC IsoId=Q70EL1-6; Sequence=VSP_035675, VSP_035676;
CC Name=4;
CC IsoId=Q70EL1-7; Sequence=VSP_029922;
CC Name=5;
CC IsoId=Q70EL1-8; Sequence=VSP_035674;
CC Name=6;
CC IsoId=Q70EL1-9; Sequence=VSP_035674, VSP_035678;
CC Name=7;
CC IsoId=Q70EL1-10; Sequence=VSP_035674, VSP_035677;
CC -!- TISSUE SPECIFICITY: Weakly expressed in a few tissues.
CC {ECO:0000269|PubMed:14715245}.
CC -!- SIMILARITY: Belongs to the peptidase C19 family. {ECO:0000305}.
CC -!- CAUTION: Although the active site residues are conserved, it lacks the
CC conserved His residue which is normally found 9 residues before the
CC catalytic His. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04393.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAG53943.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BX649087; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ583820; CAE47747.1; -; mRNA.
DR EMBL; AK094637; BAC04393.1; ALT_INIT; mRNA.
DR EMBL; AK123711; BAG53943.1; ALT_INIT; mRNA.
DR EMBL; AK126497; BAC86566.1; -; mRNA.
DR EMBL; AK127213; BAC86886.1; -; mRNA.
DR EMBL; AK127267; BAC86907.1; -; mRNA.
DR EMBL; BX649087; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC073389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL359074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC064967; AAH64967.1; -; mRNA.
DR EMBL; BC130633; AAI30634.1; -; mRNA.
DR CCDS; CCDS7329.2; -. [Q70EL1-1]
DR RefSeq; NP_001307366.1; NM_001320437.1.
DR RefSeq; NP_689799.3; NM_152586.3. [Q70EL1-1]
DR RefSeq; XP_016871263.1; XM_017015774.1. [Q70EL1-1]
DR RefSeq; XP_016871264.1; XM_017015775.1. [Q70EL1-1]
DR RefSeq; XP_016871265.1; XM_017015776.1.
DR RefSeq; XP_016871266.1; XM_017015777.1. [Q70EL1-1]
DR AlphaFoldDB; Q70EL1; -.
DR BioGRID; 127739; 198.
DR IntAct; Q70EL1; 138.
DR MINT; Q70EL1; -.
DR STRING; 9606.ENSP00000345216; -.
DR MEROPS; C19.080; -.
DR iPTMnet; Q70EL1; -.
DR PhosphoSitePlus; Q70EL1; -.
DR BioMuta; USP54; -.
DR DMDM; 215274237; -.
DR EPD; Q70EL1; -.
DR jPOST; Q70EL1; -.
DR MassIVE; Q70EL1; -.
DR MaxQB; Q70EL1; -.
DR PaxDb; Q70EL1; -.
DR PeptideAtlas; Q70EL1; -.
DR PRIDE; Q70EL1; -.
DR ProteomicsDB; 68538; -. [Q70EL1-1]
DR ProteomicsDB; 68539; -. [Q70EL1-10]
DR ProteomicsDB; 68540; -. [Q70EL1-4]
DR ProteomicsDB; 68541; -. [Q70EL1-6]
DR ProteomicsDB; 68542; -. [Q70EL1-7]
DR ProteomicsDB; 68543; -. [Q70EL1-8]
DR ProteomicsDB; 68544; -. [Q70EL1-9]
DR Antibodypedia; 54962; 80 antibodies from 17 providers.
DR DNASU; 159195; -.
DR Ensembl; ENST00000339859.8; ENSP00000345216.4; ENSG00000166348.20. [Q70EL1-1]
DR Ensembl; ENST00000687698.1; ENSP00000510226.1; ENSG00000166348.20. [Q70EL1-1]
DR GeneID; 159195; -.
DR KEGG; hsa:159195; -.
DR MANE-Select; ENST00000687698.1; ENSP00000510226.1; NM_001391956.1; NP_001378885.1.
DR UCSC; uc001juo.4; human. [Q70EL1-1]
DR CTD; 159195; -.
DR DisGeNET; 159195; -.
DR GeneCards; USP54; -.
DR HGNC; HGNC:23513; USP54.
DR HPA; ENSG00000166348; Tissue enhanced (brain).
DR neXtProt; NX_Q70EL1; -.
DR OpenTargets; ENSG00000166348; -.
DR PharmGKB; PA134959960; -.
DR VEuPathDB; HostDB:ENSG00000166348; -.
DR eggNOG; KOG1887; Eukaryota.
DR GeneTree; ENSGT00940000155571; -.
DR HOGENOM; CLU_004234_0_0_1; -.
DR InParanoid; Q70EL1; -.
DR OMA; YGAENFH; -.
DR OrthoDB; 101145at2759; -.
DR PhylomeDB; Q70EL1; -.
DR TreeFam; TF336130; -.
DR PathwayCommons; Q70EL1; -.
DR SignaLink; Q70EL1; -.
DR BioGRID-ORCS; 159195; 17 hits in 1091 CRISPR screens.
DR ChiTaRS; USP54; human.
DR GenomeRNAi; 159195; -.
DR Pharos; Q70EL1; Tdark.
DR PRO; PR:Q70EL1; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q70EL1; protein.
DR Bgee; ENSG00000166348; Expressed in tibialis anterior and 181 other tissues.
DR ExpressionAtlas; Q70EL1; baseline and differential.
DR Genevisible; Q70EL1; HS.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0016579; P:protein deubiquitination; IEA:InterPro.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR040142; USP54.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR22975:SF5; PTHR22975:SF5; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Methylation; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..1684
FT /note="Inactive ubiquitin carboxyl-terminal hydrolase 54"
FT /id="PRO_0000249530"
FT DOMAIN 31..352
FT /note="USP"
FT REGION 374..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1334..1391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1425..1455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1620..1652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 736..770
FT /evidence="ECO:0000255"
FT COMPBIAS 397..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1334..1349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 12
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8BL06"
FT MOD_RES 481
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6IE24"
FT MOD_RES 603
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 632
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 671
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 674
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BL06"
FT MOD_RES 1189
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6IE24"
FT VAR_SEQ 1..912
FT /note="Missing (in isoform 5, isoform 6 and isoform 7)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_035674"
FT VAR_SEQ 126..275
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_029922"
FT VAR_SEQ 383..403
FT /note="REPSISSDTRTDSSTESYPYK -> EQPGSLPLLSPHPMRSNSWDS (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14715245"
FT /id="VSP_026525"
FT VAR_SEQ 404..1684
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14715245"
FT /id="VSP_026526"
FT VAR_SEQ 893
FT /note="S -> R (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_035675"
FT VAR_SEQ 894..1684
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_035676"
FT VAR_SEQ 1386..1390
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_035677"
FT VAR_SEQ 1391..1437
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_035678"
FT VARIANT 505
FT /note="L -> V (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036360"
FT VARIANT 976
FT /note="K -> E (in dbSNP:rs1618542)"
FT /id="VAR_047258"
FT VARIANT 1231
FT /note="D -> N (in dbSNP:rs4619071)"
FT /id="VAR_047259"
FT VARIANT 1367
FT /note="G -> D (in dbSNP:rs7083344)"
FT /id="VAR_047260"
FT CONFLICT 110..111
FT /note="EQ -> KE (in Ref. 3; BX649087)"
FT /evidence="ECO:0000305"
FT CONFLICT 191
FT /note="C -> S (in Ref. 1; CAE47747)"
FT /evidence="ECO:0000305"
FT CONFLICT 226
FT /note="P -> L (in Ref. 3; BX649087)"
FT /evidence="ECO:0000305"
FT CONFLICT 733
FT /note="E -> G (in Ref. 3; BX649087)"
FT /evidence="ECO:0000305"
FT CONFLICT 1345
FT /note="H -> P (in Ref. 2; BAC04393)"
FT /evidence="ECO:0000305"
FT CONFLICT 1425
FT /note="S -> P (in Ref. 2; BAC86566)"
FT /evidence="ECO:0000305"
FT CONFLICT 1438
FT /note="D -> H (in Ref. 5; AAI30634)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1684 AA; 187388 MW; 853D9CFCB35C63C4 CRC64;
MSWKRNYFSG GRGSVQGMFA PRSSTSIAPS KGLSNEPGQN SCFLNSALQV LWHLDIFRRS
FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR SALAKTFQDE QRFQLGIMDD
AAECFENLLM RIHFHIADET KEDICTAQHC ISHQKFAMTL FEQCVCTSCG ATSDPLPFIQ
MVHYISTTSL CNQAICMLER REKPSPSMFG ELLQNASTMG DLRNCPSNCG ERIRIRRVLM
NAPQIITIGL VWDSDHSDLA EDVIHSLGTC LKLGDLFFRV TDDRAKQSEL YLVGMICYYG
KHYSTFFFQT KIRKWMYFDD AHVKEIGPKW KDVVTKCIKG HYQPLLLLYA DPQGTPVSTQ
DLPPQAEFQS YSRTCYDSED SGREPSISSD TRTDSSTESY PYKHSHHESV VSHFSSDSQG
TVIYNVENDS MSQSSRDTGH LTDSECNQKH TSKKGSLIER KRSSGRVRRK GDEPQASGYH
SEGETLKEKQ APRNASKPSS STNRLRDFKE TVSNMIHNRP SLASQTNVGS HCRGRGGDQP
DKKPPRTLPL HSRDWEIEST SSESKSSSSS KYRPTWRPKR ESLNIDSIFS KDKRKHCGYT
QLSPFSEDSA KEFIPDEPSK PPSYDIKFGG PSPQYKRWGP ARPGSHLLEQ HPRLIQRMES
GYESSERNSS SPVSLDAALP ESSNVYRDPS AKRSAGLVPS WRHIPKSHSS SILEVDSTAS
MGGWTKSQPF SGEEISSKSE LDELQEEVAR RAQEQELRRK REKELEAAKG FNPHPSRFMD
LDELQNQGRS DGFERSLQEA ESVFEESLHL EQKGDCAAAL ALCNEAISKL RLALHGASCS
THSRALVDKK LQISIRKARS LQDRMQQQQS PQQPSQPSAC LPTQAGTLSQ PTSEQPIPLQ
VLLSQEAQLE SGMDTEFGAS SFFHSPASCH ESHSSLSPES SAPQHSSPSR SALKLLTSVE
VDNIEPSAFH RQGLPKAPGW TEKNSHHSWE PLDAPEGKLQ GSRCDNSSCS KLPPQEGRGI
AQEQLFQEKK DPANPSPVMP GIATSERGDE HSLGCSPSNS SAQPSLPLYR TCHPIMPVAS
SFVLHCPDPV QKTNQCLQGQ SLKTSLTLKV DRGSEETYRP EFPSTKGLVR SLAEQFQRMQ
GVSMRDSTGF KDRSLSGSLR KNSSPSDSKP PFSQGQEKGH WPWAKQQSSL EGGDRPLSWE
ESTEHSSLAL NSGLPNGETS SGGQPRLAEP DIYQEKLSQV RDVRSKDLGS STDLGTSLPL
DSWVNITRFC DSQLKHGAPR PGMKSSPHDS HTCVTYPERN HILLHPHWNQ DTEQETSELE
SLYQASLQAS QAGCSGWGQQ DTAWHPLSQT GSADGMGRRL HSAHDPGLSK TSTAEMEHGL
HEARTVRTSQ ATPCRGLSRE CGEDEQYSAE NLRRISRSLS GTVVSEREEA PVSSHSFDSS
NVRKPLETGH RCSSSSSLPV IHDPSVFLLG PQLYLPQPQF LSPDVLMPTM AGEPNRLPGT
SRSVQQFLAM CDRGETSQGA KYTGRTLNYQ SLPHRSRTDN SWAPWSETNQ HIGTRFLTTP
GCNPQLTYTA TLPERSKGLQ VPHTQSWSDL FHSPSHPPIV HPVYPPSSSL HVPLRSAWNS
DPVPGSRTPG PRRVDMPPDD DWRQSSYASH SGHRRTVGEG FLFVLSDAPR REQIRARVLQ
HSQW
