UBQL3_HUMAN
ID UBQL3_HUMAN Reviewed; 655 AA.
AC Q9H347; Q9NRE0;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Ubiquilin-3;
GN Name=UBQLN3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA Felsenfeld G., Groudine M., Hardison R.;
RT "Comparative structural and functional analysis of the olfactory receptor
RT genes flanking the human and mouse beta-globin gene clusters.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=10831842; DOI=10.1016/s0378-1119(00)00122-0;
RA Conklin D., Holderman S., Whitmore T.E., Maurer M., Feldhaus A.L.;
RT "Molecular cloning, chromosome mapping and characterization of UBQLN3 a
RT testis-specific gene that contains an ubiquitin-like domain.";
RL Gene 249:91-98(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP REVIEW.
RX PubMed=24674348; DOI=10.1186/1471-2148-14-63;
RA Marin I.;
RT "The ubiquilin gene family: evolutionary patterns and functional
RT insights.";
RL BMC Evol. Biol. 14:63-63(2014).
RN [5]
RP STRUCTURE BY NMR OF 11-104.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the N-terminal ubiquitin-like domain in the human
RT ubiquilin 3 (UBQLN3).";
RL Submitted (JUL-2005) to the PDB data bank.
RN [6]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 19-99.
RG Structural genomics consortium (SGC);
RT "The ubiquitin-like domain of human ubiquilin 3.";
RL Submitted (JAN-2006) to the PDB data bank.
CC -!- INTERACTION:
CC Q9H347; P45381: ASPA; NbExp=3; IntAct=EBI-25832660, EBI-750475;
CC Q9H347; Q9UBB4: ATXN10; NbExp=3; IntAct=EBI-25832660, EBI-702390;
CC Q9H347; P07686: HEXB; NbExp=3; IntAct=EBI-25832660, EBI-7133736;
CC Q9H347; O14901: KLF11; NbExp=3; IntAct=EBI-25832660, EBI-948266;
CC Q9H347; P29474: NOS3; NbExp=3; IntAct=EBI-25832660, EBI-1391623;
CC Q9H347; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-25832660, EBI-2811583;
CC -!- TISSUE SPECIFICITY: Testis specific. {ECO:0000269|PubMed:10831842}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG41675.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF137396; AAG41675.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AF230481; AAF67143.1; -; mRNA.
DR EMBL; BC036743; AAH36743.1; -; mRNA.
DR CCDS; CCDS7758.1; -.
DR RefSeq; NP_001334025.1; NM_001347096.1.
DR RefSeq; NP_059509.1; NM_017481.3.
DR PDB; 1WX7; NMR; -; A=12-104.
DR PDB; 1YQB; X-ray; 2.00 A; A=19-99.
DR PDB; 2DAH; NMR; -; A=615-655.
DR PDBsum; 1WX7; -.
DR PDBsum; 1YQB; -.
DR PDBsum; 2DAH; -.
DR AlphaFoldDB; Q9H347; -.
DR BMRB; Q9H347; -.
DR SMR; Q9H347; -.
DR IntAct; Q9H347; 7.
DR STRING; 9606.ENSP00000347997; -.
DR iPTMnet; Q9H347; -.
DR PhosphoSitePlus; Q9H347; -.
DR BioMuta; UBQLN3; -.
DR DMDM; 48474643; -.
DR jPOST; Q9H347; -.
DR MassIVE; Q9H347; -.
DR MaxQB; Q9H347; -.
DR PaxDb; Q9H347; -.
DR PeptideAtlas; Q9H347; -.
DR PRIDE; Q9H347; -.
DR ProteomicsDB; 80676; -.
DR Antibodypedia; 11058; 220 antibodies from 26 providers.
DR DNASU; 50613; -.
DR Ensembl; ENST00000311659.5; ENSP00000347997.2; ENSG00000175520.9.
DR GeneID; 50613; -.
DR KEGG; hsa:50613; -.
DR MANE-Select; ENST00000311659.5; ENSP00000347997.2; NM_017481.4; NP_059509.1.
DR UCSC; uc001may.2; human.
DR CTD; 50613; -.
DR GeneCards; UBQLN3; -.
DR HGNC; HGNC:12510; UBQLN3.
DR HPA; ENSG00000175520; Tissue enriched (testis).
DR MIM; 605473; gene.
DR neXtProt; NX_Q9H347; -.
DR OpenTargets; ENSG00000175520; -.
DR PharmGKB; PA37157; -.
DR VEuPathDB; HostDB:ENSG00000175520; -.
DR eggNOG; KOG0010; Eukaryota.
DR GeneTree; ENSGT00940000162912; -.
DR HOGENOM; CLU_024293_3_0_1; -.
DR InParanoid; Q9H347; -.
DR OMA; EAHFRVQ; -.
DR OrthoDB; 1553668at2759; -.
DR PhylomeDB; Q9H347; -.
DR TreeFam; TF314412; -.
DR PathwayCommons; Q9H347; -.
DR SignaLink; Q9H347; -.
DR BioGRID-ORCS; 50613; 10 hits in 1066 CRISPR screens.
DR ChiTaRS; UBQLN3; human.
DR EvolutionaryTrace; Q9H347; -.
DR GenomeRNAi; 50613; -.
DR Pharos; Q9H347; Tdark.
DR PRO; PR:Q9H347; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H347; protein.
DR Bgee; ENSG00000175520; Expressed in sperm and 41 other tissues.
DR ExpressionAtlas; Q9H347; baseline and differential.
DR Genevisible; Q9H347; HS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0033554; P:cellular response to stress; IEA:UniProt.
DR GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:UniProt.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR InterPro; IPR006636; STI1_HS-bd.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00727; STI1; 1.
DR SMART; SM00165; UBA; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..655
FT /note="Ubiquilin-3"
FT /id="PRO_0000211013"
FT DOMAIN 22..98
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT DOMAIN 194..233
FT /note="STI1"
FT /evidence="ECO:0000255"
FT DOMAIN 609..655
FT /note="UBA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT REGION 102..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 255
FT /note="C -> R (in dbSNP:rs2234446)"
FT /id="VAR_052681"
FT VARIANT 285
FT /note="N -> D (in dbSNP:rs2234449)"
FT /id="VAR_052682"
FT VARIANT 287
FT /note="T -> A (in dbSNP:rs2234450)"
FT /id="VAR_052683"
FT VARIANT 290
FT /note="T -> S (in dbSNP:rs2234451)"
FT /id="VAR_052684"
FT VARIANT 546
FT /note="M -> T (in dbSNP:rs2234455)"
FT /id="VAR_034578"
FT VARIANT 624
FT /note="R -> Q (in dbSNP:rs2227271)"
FT /id="VAR_020363"
FT STRAND 21..27
FT /evidence="ECO:0007829|PDB:1YQB"
FT STRAND 32..38
FT /evidence="ECO:0007829|PDB:1YQB"
FT HELIX 43..54
FT /evidence="ECO:0007829|PDB:1YQB"
FT HELIX 58..60
FT /evidence="ECO:0007829|PDB:1YQB"
FT STRAND 61..65
FT /evidence="ECO:0007829|PDB:1YQB"
FT HELIX 76..79
FT /evidence="ECO:0007829|PDB:1YQB"
FT STRAND 86..91
FT /evidence="ECO:0007829|PDB:1YQB"
FT HELIX 617..626
FT /evidence="ECO:0007829|PDB:2DAH"
FT HELIX 631..641
FT /evidence="ECO:0007829|PDB:2DAH"
FT HELIX 645..655
FT /evidence="ECO:0007829|PDB:2DAH"
SQ SEQUENCE 655 AA; 70841 MW; 6961DA801CE91F27 CRC64;
MAKGGEALPQ GSPAPVQDPH LIKVTVKTPK DKEDFSVTDT CTIQQLKEEI SQRFKAHPDQ
LVLIFAGKIL KDPDSLAQCG VRDGLTVHLV IKRQHRAMGN ECPAASVPTQ GPSPGSLPQP
SSIYPADGPP AFSLGLLTGL SRLGLAYRGF PDQPSSLMRQ HVSVPEFVTQ LIDDPFIPGL
LSNTGLVRQL VLDNPHMQQL IQHNPEIGHI LNNPEIMRQT LEFLRNPAMM QEMIRSQDRV
LSNLESIPGG YNVLCTMYTD IMDPMLNAVQ EQFGGNPFAT ATTDNATTTT SQPSRMENCD
PLPNPWTSTH GGSGSRQGRQ DGDQDAPDIR NRFPNFLGII RLYDYLQQLH ENPQSLGTYL
QGTASALSQS QEPPPSVNRV PPSSPSSQEP GSGQPLPEES VAIKGRSSCP AFLRYPTENS
TGQGGDQDGA GKSSTGHSTN LPDLVSGLGD SANRVPFAPL SFSPTAAIPG IPEPPWLPSP
AYPRSLRPDG MNPAPQLQDE IQPQLPLLMH LQAAMANPRA LQALRQIEQG LQVLATEAPR
LLLWFMPCLA GTGSVAGGIE SREDPLMSED PLPNPPPEVF PALDSAELGF LSPPFLHMLQ
DLVSTNPQQL QPEAHFQVQL EQLRSMGFLN REANLQALIA TGGDVDAAVE KLRQS
