UBQL3_MOUSE
ID UBQL3_MOUSE Reviewed; 658 AA.
AC Q8C5U9;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Ubiquilin-3;
GN Name=Ubqln3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=25776854; DOI=10.1002/mrd.22475;
RA Yuan S., Qin W., Riordan C.R., Mcswiggin H., Zheng H., Yan W.;
RT "Ubqln3, a testis-specific gene, is dispensable for embryonic development
RT and spermatogenesis in mice.";
RL Mol. Reprod. Dev. 82:266-267(2015).
CC -!- TISSUE SPECIFICITY: Testis-specific (at protein level).
CC {ECO:0000269|PubMed:25776854}.
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DR EMBL; AK077072; BAC36593.1; -; mRNA.
DR CCDS; CCDS21610.1; -.
DR RefSeq; NP_941025.1; NM_198623.2.
DR AlphaFoldDB; Q8C5U9; -.
DR SMR; Q8C5U9; -.
DR BioGRID; 232612; 2.
DR STRING; 10090.ENSMUSP00000055229; -.
DR iPTMnet; Q8C5U9; -.
DR PhosphoSitePlus; Q8C5U9; -.
DR MaxQB; Q8C5U9; -.
DR PaxDb; Q8C5U9; -.
DR PRIDE; Q8C5U9; -.
DR ProteomicsDB; 298370; -.
DR Antibodypedia; 11058; 220 antibodies from 26 providers.
DR DNASU; 244178; -.
DR Ensembl; ENSMUST00000057254; ENSMUSP00000055229; ENSMUSG00000051618.
DR GeneID; 244178; -.
DR KEGG; mmu:244178; -.
DR UCSC; uc009ivk.1; mouse.
DR CTD; 50613; -.
DR MGI; MGI:3045291; Ubqln3.
DR VEuPathDB; HostDB:ENSMUSG00000051618; -.
DR eggNOG; KOG0010; Eukaryota.
DR GeneTree; ENSGT00940000162912; -.
DR HOGENOM; CLU_024293_3_0_1; -.
DR InParanoid; Q8C5U9; -.
DR OMA; EAHFRVQ; -.
DR OrthoDB; 1553668at2759; -.
DR PhylomeDB; Q8C5U9; -.
DR TreeFam; TF314412; -.
DR BioGRID-ORCS; 244178; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8C5U9; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8C5U9; protein.
DR Bgee; ENSMUSG00000051618; Expressed in seminiferous tubule of testis and 16 other tissues.
DR ExpressionAtlas; Q8C5U9; baseline and differential.
DR Genevisible; Q8C5U9; MM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR InterPro; IPR006636; STI1_HS-bd.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00727; STI1; 1.
DR SMART; SM00165; UBA; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..658
FT /note="Ubiquilin-3"
FT /id="PRO_0000211014"
FT DOMAIN 22..96
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT DOMAIN 194..233
FT /note="STI1"
FT /evidence="ECO:0000255"
FT DOMAIN 614..658
FT /note="UBA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT REGION 280..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 70753 MW; DE701ADC9D51809C CRC64;
MAKSGEALPQ GSLAPAQDSQ LIRVTVKTPK DKEDFSVVDT CTIRQLKEKI SHRFKAHPNQ
LVLIFAGKIL KDPDSLAQCG VRDGLTVHLV IKMQRRTIGT ECPSPPVSIP GPNPGEIPQS
SSVYSVDGSP SFSLGVLTGL SGLGLTSGSF SDQPGSLMWQ HISVPELVAQ LVDDPFIQGL
LSNTGLVRQL VLDNPHMQHL IQQNPEIGHI LNNPEIMRQT MEFLRNPSMM QEMMRSQDRA
LSNLESIPGG YNVLRTMYTD IMDPMLNAVQ EQFGGNPFVT ATTASTTTTS SQPSRTENCD
PLPNPWTSTY GVSGGRQGRG GRQSGDQDAS ENRNRLPSFL GNIGLFDYLQ QLHETSQSLE
SYLQGTVPTS NPSQESPLSG NRVPPTLPSS PKSGSGQSLP KESVAIKGKS SCPAFLRHST
ENSTGQGGSL HDAGKGSTGP STSLPNLTSQ IGDSANRSSF VSTPSSLMSA TPGVPESPWL
PPTGYSRSLR SAGTNQVPRI QNEIHQQLPL LLHLQTAMAN PRVMQALLQI EQGLQILATE
APRLLLWFMP CLTGLNGVTG GTEAREGVVM SEDPRPTPTP QISLAQGSTE LGIHSSPFLQ
VLQALASTNP QQLQLEAHFR VQLEQLRAMG FLNLEANLQA LIATEGDVDA AVEKLRKS
