UBQLN_MOUSE
ID UBQLN_MOUSE Reviewed; 610 AA.
AC Q14DL0; E9QM12; Q14DR8; Q8BVT0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Ubiquilin-like protein;
GN Name=Ubqlnl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP STRUCTURE BY NMR OF 556-609.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of RSGI RUH-056, a UBA domain from mouse cDNA.";
RL Submitted (OCT-2006) to the PDB data bank.
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DR EMBL; AK076645; BAC36434.1; -; mRNA.
DR EMBL; AC123830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC111901; AAI11902.1; -; mRNA.
DR EMBL; BC113134; AAI13135.1; -; mRNA.
DR CCDS; CCDS21611.1; -.
DR RefSeq; NP_941026.2; NM_198624.3.
DR PDB; 2DNA; NMR; -; A=557-610.
DR PDBsum; 2DNA; -.
DR AlphaFoldDB; Q14DL0; -.
DR SMR; Q14DL0; -.
DR STRING; 10090.ENSMUSP00000056365; -.
DR iPTMnet; Q14DL0; -.
DR PhosphoSitePlus; Q14DL0; -.
DR PaxDb; Q14DL0; -.
DR PRIDE; Q14DL0; -.
DR ProteomicsDB; 297796; -.
DR Antibodypedia; 23640; 78 antibodies from 20 providers.
DR DNASU; 244179; -.
DR Ensembl; ENSMUST00000059121; ENSMUSP00000056365; ENSMUSG00000051437.
DR GeneID; 244179; -.
DR KEGG; mmu:244179; -.
DR UCSC; uc009ivl.1; mouse.
DR CTD; 143630; -.
DR MGI; MGI:2685336; Ubqlnl.
DR VEuPathDB; HostDB:ENSMUSG00000051437; -.
DR eggNOG; KOG0010; Eukaryota.
DR GeneTree; ENSGT00940000163345; -.
DR HOGENOM; CLU_024293_4_0_1; -.
DR InParanoid; Q14DL0; -.
DR OMA; LSAHFKC; -.
DR OrthoDB; 1553668at2759; -.
DR PhylomeDB; Q14DL0; -.
DR TreeFam; TF314412; -.
DR BioGRID-ORCS; 244179; 2 hits in 73 CRISPR screens.
DR EvolutionaryTrace; Q14DL0; -.
DR PRO; PR:Q14DL0; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q14DL0; protein.
DR Bgee; ENSMUSG00000051437; Expressed in seminiferous tubule of testis and 3 other tissues.
DR Genevisible; Q14DL0; MM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..610
FT /note="Ubiquilin-like protein"
FT /id="PRO_0000307792"
FT DOMAIN 31..105
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT DOMAIN 562..607
FT /note="UBA"
FT CONFLICT 17
FT /note="T -> P (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 52
FT /note="V -> G (in Ref. 1; BAC36434)"
FT /evidence="ECO:0000305"
FT CONFLICT 58
FT /note="I -> M (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 82
FT /note="H -> Y (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="S -> C (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 142
FT /note="N -> S (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 145
FT /note="K -> I (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="Missing (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="S -> G (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="P -> Q (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 256
FT /note="F -> Y (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="V -> A (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 345
FT /note="P -> S (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 383
FT /note="S -> P (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 387
FT /note="K -> E (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 395
FT /note="T -> A (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 423
FT /note="G -> R (in Ref. 3; AAI13135)"
FT /evidence="ECO:0000305"
FT CONFLICT 445
FT /note="S -> P (in Ref. 3; AAI11902/AAI13135)"
FT /evidence="ECO:0000305"
FT CONFLICT 460
FT /note="Q -> H (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 517
FT /note="S -> G (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT CONFLICT 522
FT /note="V -> E (in Ref. 1; BAC36434)"
FT /evidence="ECO:0000305"
FT CONFLICT 553
FT /note="P -> L (in Ref. 3; AAI11902)"
FT /evidence="ECO:0000305"
FT HELIX 564..567
FT /evidence="ECO:0007829|PDB:2DNA"
FT HELIX 569..578
FT /evidence="ECO:0007829|PDB:2DNA"
FT HELIX 583..592
FT /evidence="ECO:0007829|PDB:2DNA"
FT HELIX 597..606
FT /evidence="ECO:0007829|PDB:2DNA"
SQ SEQUENCE 610 AA; 67566 MW; 48F57D85DA7CF840 CRC64;
MPRIISRSPK MPQSRYTAGV PADGKISPGV IRVIVKTPGN QIIFTVADDT LVRQFKEILS
AHFKCQMEQL VLVFMGRLLK DHDTLSQRGI TDGHIIHVVI KSKHGPRSLA HSFRNLVTNN
PCHQDRNPKG NSSMVCQSAG MNETKVESSL LMEPEAPKVG TESPEVGSLE HIAQVLENLC
VQSLLSNMDF VHQMPPEQPY MEELIQQNPE VSHLLDNSEI LCQTLELVRH LAIIQEIMQI
QQPAQNPEYP PNSQPFLGLE TVPNGNNHLG QSYVNNNDHM LNGVPDLLEG NCFTALLDEQ
VLEQVQTPSL SQPLPQEQWD QLSSSQVIYA NSCGLSSITP TNATPNHTNN VSRENPAIVA
TQGQSNVCAV QQPAEIPVLP TISINQKPQV DKDTTITLGI SDQWLEEDLQ QSDDQTSSQI
TGGMIQLLRN HPQMAAQMLL LMNTSQLNEQ WRQETPTPLQ SSQLHDLLLA LANPKTSQAL
LQIEHGLQLL ATEAPALLPY IEPYLWGLGW LIPSICSYPD IVPWTWNVQD MAEPQCPESC
HKSETVLQKV QPPSGDPSHS LQAPEVRFSK EMECLQAMGF VNYNANLQAL IATDGDTNAA
IYKLKSSQGF
