UBQL_DICDI
ID UBQL_DICDI Reviewed; 523 AA.
AC Q9NIF3; Q55FU4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Ubiquilin;
DE AltName: Full=Suppressor of NosA;
GN Name=ubqln; Synonyms=sonA; ORFNames=DDB_G0267452;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=AX3;
RX PubMed=11118648; DOI=10.1016/s0167-4889(00)00124-5;
RA Pukatzki S., Ennis H.L., Kessin R.H.;
RT "A genetic interaction between a ubiquitin-like protein and ubiquitin-
RT mediated proteolysis in Dictyostelium discoideum.";
RL Biochim. Biophys. Acta 1499:154-163(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA Soldati T.;
RT "Proteomics fingerprinting of phagosome maturation and evidence for the
RT role of a Galpha during uptake.";
RL Mol. Cell. Proteomics 5:2228-2243(2006).
CC -!- FUNCTION: Stable protein which acts as an antagonist of nosA by
CC repressing cellular differentiation after the tight-aggregate stage,
CC when cells differentiate into two precursor cell types, prespore and
CC prestalk cells, prior to the formation of fruiting bodies.
CC {ECO:0000269|PubMed:11118648}.
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DR EMBL; AF214118; AAF43003.1; -; mRNA.
DR EMBL; AAFI02000003; EAL73179.1; -; Genomic_DNA.
DR RefSeq; XP_647439.1; XM_642347.1.
DR AlphaFoldDB; Q9NIF3; -.
DR SMR; Q9NIF3; -.
DR STRING; 44689.DDB0191158; -.
DR PaxDb; Q9NIF3; -.
DR EnsemblProtists; EAL73179; EAL73179; DDB_G0267452.
DR GeneID; 8616246; -.
DR KEGG; ddi:DDB_G0267452; -.
DR dictyBase; DDB_G0267452; sonA.
DR eggNOG; KOG0010; Eukaryota.
DR HOGENOM; CLU_024293_4_0_1; -.
DR InParanoid; Q9NIF3; -.
DR OMA; GMDMFGP; -.
DR PhylomeDB; Q9NIF3; -.
DR Reactome; R-DDI-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR PRO; PR:Q9NIF3; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR InterPro; IPR006636; STI1_HS-bd.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019956; Ubiquitin_dom.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR PRINTS; PR00348; UBIQUITIN.
DR SMART; SM00727; STI1; 4.
DR SMART; SM00165; UBA; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Reference proteome; Repeat.
FT CHAIN 1..523
FT /note="Ubiquilin"
FT /id="PRO_0000327824"
FT DOMAIN 2..77
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT DOMAIN 100..135
FT /note="STI1 1"
FT DOMAIN 139..178
FT /note="STI1 2"
FT DOMAIN 339..380
FT /note="STI1 3"
FT DOMAIN 383..415
FT /note="STI1 4"
FT DOMAIN 480..523
FT /note="UBA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT REGION 70..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..87
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 523 AA; 56671 MW; 62F5C127761A5133 CRC64;
MVKINIKSST DNKFDVDVEL GITVADFKKV IATKCSIPAD QQRIIYSGRI LKDHQTLDEI
KIQDGHTVHL VKGAAPPPPP PVEQQVPTPS NTQPQGIPGV PQNINDMMNN PMIQEMFNSR
MMDSLLDNPD IFRDMMMGNP EMREVLNNNP EMAQMLSDPR QLRQSLEMMR NPELMREMMR
NADRAMINIE NHPEGFNLLR RMYTDIQEPL MNAANQQAAS QNQTNSNPIQ TNTDANPNSQ
PLPNPWSTNS SSTSSNPTSS SPSSRPTTGS STNTGASNPW ASMFSGGGGG MGGGTNNTGT
NNTGSTNNTG ASNPWASMFG GGGGGMGGMG GMEGMLGMDP ERVQQLLNNP VAQQMMQRLM
SDPAMMQQMI TMNPQLRQMM DSNPQLREAM NNPEFLNMMT NPENMNAMMQ LQQAMGTLRN
NGVFPGGMGG MGGMGGMGGM GGMGGMDFSQ FGNMFGGMGG MGGMGNNNSS TTRPPVNQEP
PEQRFRLQLE QLEELGFVDR AANISALTST NGNINLAIDR LLR
