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UBR1_KLULA
ID   UBR1_KLULA              Reviewed;        1945 AA.
AC   O60014; Q6CJX1;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=E3 ubiquitin-protein ligase UBR1;
DE            EC=2.3.2.27;
DE   AltName: Full=N-end-recognizing protein;
DE   AltName: Full=N-recognin-1;
DE   AltName: Full=RING-type E3 ubiquitin transferase UBR1;
GN   Name=UBR1; OrderedLocusNames=KLLA0F15334g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Waller P.R.H., Varshavsky A.;
RT   "Kluyveromyces lactis UBR1, the recognition component of the N-end rule
RT   pathway.";
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Ubiquitin ligase protein which is a component of the N-end
CC       rule pathway. Recognizes and binds to proteins bearing specific N-
CC       terminal residues that are destabilizing according to the N-end rule,
CC       leading to their ubiquitination and subsequent degradation.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27;
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The RING-H2 zinc finger is an atypical RING finger with a His
CC       ligand in place of the fourth Cys of the classical motif.
CC   -!- SIMILARITY: Belongs to the UBR1 family. {ECO:0000305}.
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DR   EMBL; AF061554; AAC15841.1; -; Genomic_DNA.
DR   EMBL; CR382126; CAG98476.1; -; Genomic_DNA.
DR   PIR; T30554; T30554.
DR   RefSeq; XP_455768.1; XM_455768.1.
DR   AlphaFoldDB; O60014; -.
DR   SMR; O60014; -.
DR   STRING; 28985.XP_455768.1; -.
DR   PRIDE; O60014; -.
DR   EnsemblFungi; CAG98476; CAG98476; KLLA0_F15334g.
DR   GeneID; 2895834; -.
DR   KEGG; kla:KLLA0_F15334g; -.
DR   eggNOG; KOG1140; Eukaryota.
DR   HOGENOM; CLU_238060_0_0_1; -.
DR   InParanoid; O60014; -.
DR   OMA; WANTISM; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:EnsemblFungi.
DR   GO; GO:1990303; C:UBR1-RAD6 ubiquitin ligase complex; IEA:EnsemblFungi.
DR   GO; GO:1904855; F:proteasome regulatory particle binding; IEA:EnsemblFungi.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0071629; P:cytoplasm protein quality control by the ubiquitin-proteasome system; IEA:EnsemblFungi.
DR   GO; GO:0072671; P:mitochondria-associated ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006513; P:protein monoubiquitination; IEA:EnsemblFungi.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:EnsemblFungi.
DR   GO; GO:0090089; P:regulation of dipeptide transport; IEA:EnsemblFungi.
DR   GO; GO:1990116; P:ribosome-associated ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0120174; P:stress-induced homeostatically regulated protein degradation pathway; IEA:EnsemblFungi.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:EnsemblFungi.
DR   GO; GO:0071596; P:ubiquitin-dependent protein catabolic process via the N-end rule pathway; IEA:EnsemblFungi.
DR   InterPro; IPR044046; E3_ligase_UBR-like_C.
DR   InterPro; IPR039164; UBR1-like.
DR   InterPro; IPR003126; Znf_UBR.
DR   PANTHER; PTHR21497; PTHR21497; 1.
DR   Pfam; PF18995; PRT6_C; 1.
DR   Pfam; PF02207; zf-UBR; 1.
DR   SMART; SM00396; ZnF_UBR1; 1.
DR   PROSITE; PS51157; ZF_UBR; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Reference proteome; Transferase; Ubl conjugation pathway;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..1945
FT                   /note="E3 ubiquitin-protein ligase UBR1"
FT                   /id="PRO_0000056133"
FT   ZN_FING         109..182
FT                   /note="UBR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00508"
FT   ZN_FING         1193..1300
FT                   /note="RING-type; atypical"
FT   REGION          1901..1945
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1907..1933
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        238..244
FT                   /note="IQNGKYN -> NPEREIY (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        266..271
FT                   /note="QQQTPS -> SNKRHL (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        289
FT                   /note="N -> Y (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        339..340
FT                   /note="GF -> RI (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        507
FT                   /note="H -> Q (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        526
FT                   /note="V -> G (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        564
FT                   /note="V -> L (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        645..646
FT                   /note="RK -> KKR (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        726
FT                   /note="R -> Q (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        738
FT                   /note="S -> C (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        938..956
FT                   /note="LEDNGVFKLKKELYKRIDS -> SKIWCFQTKEGTLQENRF (in Ref.
FT                   1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1389
FT                   /note="M -> L (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1435..1452
FT                   /note="NVLKFYEDIRSSNLPSYP -> MYSNSMKIFVAAIYQVIR (in Ref. 1;
FT                   AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1578
FT                   /note="T -> A (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1621
FT                   /note="E -> D (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1934
FT                   /note="Missing (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1938..1945
FT                   /note="FNELNNVE -> LISTS (in Ref. 1; AAC15841)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1945 AA;  224077 MW;  61BA660BBC32AB48 CRC64;
     MINDTDPESF LRQHVGRTLG CIHSRPEFKD IKGSAERAVM DKELKSFIYG YYYYMISDSG
     RLLPHMFTAT NEREFPKNVD QAMEIKLSSK PWYKIDENGG HSKFNHAGRI CGAKFRVGEP
     IYRCKECSFD DTCVLCVNCF NPKDHVGHHV YTSICTEFNN GICDCGDKEA WNHELNCKGA
     EDNGRLEDEF DDHDGKISKM LESVLIELFD HFIDVFNQNI EPLTTIQKPL IAKLRYFIQN
     GKYNEQADML RRLAYRNQYM DEEESQQQTP STSLDPLSTL KDYAILVYND EFHNYSQASA
     AIRQGGPDNK HIDLLTAKID SEGRSLLRCS ADIASLMGGF FSVQSNGLSC TITQWYEYLH
     QEACKYSIMW INDCLNIPNS TFQSLFRNAI GKVLCSKYEP FYQSIDMTSV VRDYFSDSYL
     SDDPYLYADH SVLGEGVKIP LGRHKSLDPG DISAISPILN KVIAEDHHEY TNSRLQYVLF
     LENRYWKKLR KIVQDLIIPT LASSAVHKPM FTDQLVEIFP HMTRSVTFMD REPQLTSLRE
     SVVQLFTCPT TAYSIFHSGH FNYVIWSVID VFVDFSTMDE GTLVWQRVQR SNPSKSYSIS
     FKQGLYAVET LLSKITDPNL LLKPGEFIMI VTLCKLFNGA WKIKRKEGEH VLREDQHFIP
     YLEYTTSVYS IIQTFDKVLQ QSKDHIDQRL LIGAINLLDS FLGHRNLSYK LYKDFEIIKF
     QISKERVSFM NPVHTLFSFL VQHVPLQVSI QVLSQSKDYL VISDFALRSV VLCSQIDIGF
     WVRNGMSVLH QSAYYKNNPE MSSYSRDIQL NQLAFLIEKN DFQRVIYNML DRWELLDWFD
     GSVPSTETVY DDKISSIIQQ FVAFLYQILV ERDFYKKFDT LEETQLYNIK NAIIYKLYAE
     PLSYTDLLND IPDYLTESVS QFDTVLEEVS TYIEPKGLED NGVFKLKKEL YKRIDSLRLL
     NMGNDFEHSA TIVKSHLADS KEKRAKIIVK PQLLELDELD PCARELGSFT RTNLFAKLIF
     KLLKLAVSDS SFSFTYELLH LIHAIFRDDE MVNGKDSLPE AYISKPICDL LLSIVDSESG
     SFSENVVATA DYLLDNMIMK RPTAVLESLT ECFGTKYIAD YKIRKANQGV NFEETEQERK
     RRLAKNRQQQ IMNRFSRQQK KFMDKHEEYS AGNDEDVDMD GEDLAGELNE FHCSLCHDDV
     SDDFFVIPIY QNYSPVFLSS NPTPMEIYKP WHGFDNNEHL ATYNTDLFYK KKENGASQLM
     HESTQKVLVS CNHAVHYRCF KHYIDKKRYS TDLFICPLCQ TYCNSVIPVD TVKLQSGDRL
     LQQKLTGGLD ESLLLTFSEY SSECNDEVGK IILSLKDSNN GLRLNRNDPT WIQDRFLTLS
     LQFSNNICML EMLSRLNKDP FGTLLSGEEQ KFKTLQNILK SLAVYTRLTK HTEENVLKFY
     EDIRSSNLPS YPFFRVVETV LRSRLSFKDC LQEVLVERLK GLTKDFGSFY RKYESELRAQ
     TCLDSSEFSI VLKTTILGAG FGDQVEKHTL DLFYTFLISE LLPTLRRSII LLKALKQFMT
     GGDDLDFNEK DVLSGSLTSE SKEKHFHLLI RFLLQTDFYD LLMNSHSPLS PESSLVNAPH
     EYCSIIKLTD LATHLNTYVT NNKNITLREE NDQKIRNTVN RLDYKICLIC GVKIHARTDG
     LEMQKHMERC SHGSSGLFLI PNISQVCLYL SRPDCTVNIS APYLNSHGES GRNAIERGDL
     TVLNHARYEH LTRLWISNGI PGYISRVMGD EFRVAMANNR TFTRNMFWRP GAAFNAGGES
     SDEDLMNDDE FGNDDRPDLR FRQPDVELRI NGGPFGGDIP IRLPTERGDI HDFFEFVQNM
     RGGMQGDGAD IPTTEDIIEQ LQGNAMNGFF GRADRNREHF ELNDQSDGNE DGEDEEHENN
     ASEDQDTEYS SAEEGFDFNE LNNVE
 
 
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