ID   CA043_BOVIN             Reviewed;         253 AA.
AC   Q5E943; Q17QJ8;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Protein C1orf43 homolog;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: General regulator of phagocytosis. Required to uptake Gram
CC       negative bacterium by macrophages. {ECO:0000250|UniProtKB:Q9BWL3}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q9BWL3}.
CC       Mitochondrion {ECO:0000250|UniProtKB:Q9BWL3}.
CC   -!- DOMAIN: N-terminal region is required for phagocytosis of Gram negative
CC       bacterium. {ECO:0000250|UniProtKB:Q9BWL3}.
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DR   EMBL; BT021077; AAX09094.1; -; mRNA.
DR   EMBL; BC118321; AAI18322.1; -; mRNA.
DR   RefSeq; NP_001015666.1; NM_001015666.1.
DR   AlphaFoldDB; Q5E943; -.
DR   STRING; 9913.ENSBTAP00000026674; -.
DR   PaxDb; Q5E943; -.
DR   GeneID; 538459; -.
DR   KEGG; bta:538459; -.
DR   CTD; 105928483; -.
DR   eggNOG; ENOG502QUKH; Eukaryota.
DR   OrthoDB; 1581753at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0006909; P:phagocytosis; ISS:UniProtKB.
DR   InterPro; IPR010876; C1orf43.
DR   PANTHER; PTHR21425; PTHR21425; 1.
DR   Pfam; PF07406; NICE-3; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Mitochondrion; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..253
FT                   /note="Protein C1orf43 homolog"
FT                   /id="PRO_0000089255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          194..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   253 AA;  28673 MW;  306560D8A4A02C06 CRC64;
     MASGSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV GHNAPKDLKE
     EIDIRLSKVQ DIKYEPQLLA DDDARLLQLE TQGNHNCYNY LYRMKALDAI RASEIPFHAE
     GRHPHSLMGK NFRSYLLDLR NTSTPFKGVR KALIDTLLDG YETARYGTGV FGLSEYLRYQ
     EALSELATVV KARSGSSQRQ HQSAAKDLTQ SPEVSPTTIQ VTYLPSSQKS KRAKHFLELK
     SFKDNYNTLE STL