ID   UBS1_YEAST              Reviewed;         277 AA.
AC   P38290; D6VQG1;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Ubiquitin-conjugating enzyme suppressor 1;
GN   Name=UBS1; OrderedLocusNames=YBR165W; ORFNames=YBR1217;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8552096; DOI=10.1128/mcb.16.2.677;
RA   Prendergast J.A., Ptak C., Kornitzer D., Steussy C.N., Hodgins R.,
RA   Goebl M., Ellison M.J.;
RT   "Identification of a positive regulator of the cell cycle ubiquitin-
RT   conjugating enzyme Cdc34 (Ubc3).";
RL   Mol. Cell. Biol. 16:677-684(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA   Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA   Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA   Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA   Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA   Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA   Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA   Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA   Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA   Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA   Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA   Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA   Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA   Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA   Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA   Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA   Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA   Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA   Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA   Mewes H.-W., Kleine K.;
RT   "Complete DNA sequence of yeast chromosome II.";
RL   EMBO J. 13:5795-5809(1994).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
CC   -!- FUNCTION: Not known; its elevated expression suppresses the conditional
CC       cell cycle defects associated with UBC3/CDC34 mutations.
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DR   EMBL; S80871; AAB50693.1; -; Genomic_DNA.
DR   EMBL; Z36034; CAA85126.1; -; Genomic_DNA.
DR   EMBL; AY557716; AAS56042.1; -; Genomic_DNA.
DR   EMBL; BK006936; DAA07281.1; -; Genomic_DNA.
DR   PIR; S46036; S46036.
DR   RefSeq; NP_009724.1; NM_001178513.1.
DR   AlphaFoldDB; P38290; -.
DR   BioGRID; 32865; 65.
DR   STRING; 4932.YBR165W; -.
DR   PaxDb; P38290; -.
DR   EnsemblFungi; YBR165W_mRNA; YBR165W; YBR165W.
DR   GeneID; 852463; -.
DR   KEGG; sce:YBR165W; -.
DR   SGD; S000000369; UBS1.
DR   VEuPathDB; FungiDB:YBR165W; -.
DR   eggNOG; ENOG502S1UD; Eukaryota.
DR   HOGENOM; CLU_085772_0_0_1; -.
DR   InParanoid; P38290; -.
DR   OMA; RTHDYNA; -.
DR   BioCyc; YEAST:G3O-29115-MON; -.
DR   PRO; PR:P38290; -.
DR   Proteomes; UP000002311; Chromosome II.
DR   RNAct; P38290; protein.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0006611; P:protein export from nucleus; IMP:SGD.
DR   GO; GO:0016567; P:protein ubiquitination; IMP:SGD.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..277
FT                   /note="Ubiquitin-conjugating enzyme suppressor 1"
FT                   /id="PRO_0000065713"
FT   REGION          254..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..271
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   277 AA;  32197 MW;  7AB57B0CBA1BF34B CRC64;
     MAYSLTRKLL KDWKYFMRHP EKTQGLFHVR PHDSDLHLWH VVMYEPRTSL EVYLLLYIGG
     NDQDPYIIMK CLSPNCCFPI NRTVSMTHLN YLLLKDLGLQ DLLFHIWQPL FHIQATEDLQ
     YSPSTVKFNR AWNRIIYKDF KSYFPELIGT LQPGDYSIVK SYSKNHNISN SNGGSVNEFM
     SSYNAQSHTF HAQDNSKNPY TNSSIGKSSM LSTLNNNNVN KRTHDYNAID FMTKNLLACD
     DDSIHPVVSS KRSRTLACPD ETNDNRGSEH YTKRKKI