UBS3A_DROME
ID UBS3A_DROME Reviewed; 751 AA.
AC Q9VCE9;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Protein UBASH3A homolog;
GN ORFNames=CG13604;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
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DR EMBL; AE014297; AAF56217.1; -; Genomic_DNA.
DR EMBL; AY051411; AAK92835.1; -; mRNA.
DR RefSeq; NP_651202.1; NM_142945.3.
DR AlphaFoldDB; Q9VCE9; -.
DR SMR; Q9VCE9; -.
DR BioGRID; 67775; 4.
DR DIP; DIP-21366N; -.
DR IntAct; Q9VCE9; 1.
DR STRING; 7227.FBpp0083896; -.
DR PaxDb; Q9VCE9; -.
DR DNASU; 42840; -.
DR EnsemblMetazoa; FBtr0084509; FBpp0083896; FBgn0039137.
DR GeneID; 42840; -.
DR KEGG; dme:Dmel_CG13604; -.
DR UCSC; CG13604-RA; d. melanogaster.
DR FlyBase; FBgn0039137; CG13604.
DR VEuPathDB; VectorBase:FBgn0039137; -.
DR eggNOG; KOG3734; Eukaryota.
DR GeneTree; ENSGT00940000167071; -.
DR InParanoid; Q9VCE9; -.
DR OMA; PNFMGFF; -.
DR OrthoDB; 243749at2759; -.
DR PhylomeDB; Q9VCE9; -.
DR BioGRID-ORCS; 42840; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 42840; -.
DR PRO; PR:Q9VCE9; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0039137; Expressed in eye disc (Drosophila) and 36 other tissues.
DR ExpressionAtlas; Q9VCE9; baseline and differential.
DR Genevisible; Q9VCE9; DM.
DR GO; GO:0005829; C:cytosol; ISS:FlyBase.
DR GO; GO:0102531; F:ecdysteroid-phosphate phosphatase activity; IDA:FlyBase.
DR GO; GO:0016791; F:phosphatase activity; ISS:FlyBase.
DR GO; GO:0016311; P:dephosphorylation; ISS:FlyBase.
DR GO; GO:0045455; P:ecdysteroid metabolic process; IDA:FlyBase.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.1240; -; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR Pfam; PF00300; His_Phos_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR SUPFAM; SSF53254; SSF53254; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50030; UBA; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; SH3 domain.
FT CHAIN 1..751
FT /note="Protein UBASH3A homolog"
FT /id="PRO_0000210995"
FT DOMAIN 16..60
FT /note="UBA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT DOMAIN 271..336
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 367..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..751
FT /note="Phosphatase-like"
FT COMPBIAS 367..382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 751 AA; 84466 MW; FF893BB3FEDFDB2D CRC64;
MATLPPRKSQ TPTRICISKQ HLTPLQTLLQ MGFPRHRAEK ALASTGNRGV QIASDWLLAH
VNDGTLDECA PREYIIYACP TGPFLQQLEE FWAKSRQMCG WNGAHNYVPH ITLVSFFKAP
DECSLQLSKA LKQVVDMTGA LLDRPLKLEP YMSQNFMGFF VAEEDANYLK RLALQYVKEV
SNSIISDTYE QLDAIVACFP WCGAVSSGTR CIPRSSRSIS LEPHVKSLHL TLAYQFPQAQ
FNALKALVET LDASCASNWE LRLYSRDPRL ATKQVQKVVY PHNPHETDEL ELRIGDYIYL
NTEVVDSSSD GWAEGISWLT GSTGHLPVNY TERTAESDAW TLHRVVQLSK SVASSLTSAE
DLDIVDGRSI STEPDDRQNT AHPDIIEGSS FEESEQSVEK YLRQTLKPCL ELPSVQLLNS
HNLTHQHNPN TPTIEITTNM SSSSTSMSKQ PVDEILVEPP AAQPPRPDDT LSVHSDHSLH
PGSLDASHAK NRKIYIMRHG ERVDFTFGTW IPYCFDEFGN YMRKDLNMPK TLPRRKNSPE
GWQNDSPLTN VGVYQANLIG QALLEAQVQI DHVYCSPSYR CIQTCTSALE GLKLTGKQKI
KLEPGLFEWM AWYPSGVPDW LTKNELTEAK FDVDLDYEPV QPASELTARL KESTEQFYER
NHDVILQLLE QTTGNILVVA HATTLDTCSR QLTGGVPRST NELRQVIHKI PYCSLATVEQ
VDGVWKLVEP ECLPVTHSKN PRFEWNALSA T
