ID   UBTD1_BOVIN             Reviewed;         227 AA.
AC   Q3ZBQ1;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Ubiquitin domain-containing protein 1;
GN   Name=UBTD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in the regulation of cellular senescence
CC       through a positive feedback loop with TP53. Is a TP53 downstream target
CC       gene that increases the stability of TP53 protein by promoting the
CC       ubiquitination and degradation of MDM2. {ECO:0000250|UniProtKB:Q9HAC8}.
CC   -!- SUBUNIT: Interacts with UBTD1. {ECO:0000250|UniProtKB:Q9HAC8}.
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DR   EMBL; BC103175; AAI03176.1; -; mRNA.
DR   RefSeq; NP_001029433.1; NM_001034261.2.
DR   AlphaFoldDB; Q3ZBQ1; -.
DR   SMR; Q3ZBQ1; -.
DR   STRING; 9913.ENSBTAP00000016906; -.
DR   PaxDb; Q3ZBQ1; -.
DR   PRIDE; Q3ZBQ1; -.
DR   Ensembl; ENSBTAT00000016906; ENSBTAP00000016906; ENSBTAG00000012719.
DR   GeneID; 506002; -.
DR   KEGG; bta:506002; -.
DR   CTD; 80019; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012719; -.
DR   VGNC; VGNC:36620; UBTD1.
DR   eggNOG; KOG0013; Eukaryota.
DR   GeneTree; ENSGT00940000158630; -.
DR   HOGENOM; CLU_070348_0_0_1; -.
DR   InParanoid; Q3ZBQ1; -.
DR   OMA; AWQRWFF; -.
DR   OrthoDB; 1221075at2759; -.
DR   TreeFam; TF323925; -.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000012719; Expressed in laryngeal cartilage and 104 other tissues.
DR   ExpressionAtlas; Q3ZBQ1; baseline and differential.
DR   Gene3D; 1.20.225.20; -; 1.
DR   InterPro; IPR032752; DC-UbP/UBTD2_N.
DR   InterPro; IPR038169; DC-UbP/UBTD2_N_sf.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR019956; Ubiquitin_dom.
DR   InterPro; IPR039869; UBTD1/2.
DR   PANTHER; PTHR13609; PTHR13609; 1.
DR   Pfam; PF16455; UBD; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..227
FT                   /note="Ubiquitin domain-containing protein 1"
FT                   /id="PRO_0000242673"
FT   DOMAIN          149..224
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   227 AA;  26002 MW;  52519D2B06201612 CRC64;
     MGNCVGRQRR ERPTAPGHPR KRAGRNEPLK KERLKWKSDY PMTDGQLRSK RDEFWDTAPA
     FEGRKEIWDA LKAAAYAAEA NDHELAQAIL DGASITLPHG TLCECYDELG NRYQLPIYCL
     SPPVNLLLEH TEEESLEPPE PTPSVRREFP LKVRLSTGKD VRLSASLPDT VGQLKRQLHT
     QEGIEPSWQR WFFSGKLLTD RTRLQETKIQ KDFVIQVIIN QPPPPQD