CA043_MOUSE
ID CA043_MOUSE Reviewed; 253 AA.
AC Q8R092; Q3UBD8; Q8BII4; Q8BIP7; Q8R240; Q9CV59; Q9CYB6;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein C1orf43 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Cheng J., Yang Q., Liu Y.;
RT "Identification of murine homologous gene to human NS5ATP4.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J;
RC TISSUE=Bone marrow, Embryo, Spinal ganglion, Testis, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, FVB/N, and NMRI; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION.
RX PubMed=31540829; DOI=10.1016/j.chom.2019.08.017;
RA Jeng E.E., Bhadkamkar V., Ibe N.U., Gause H., Jiang L., Chan J., Jian R.,
RA Jimenez-Morales D., Stevenson E., Krogan N.J., Swaney D.L., Snyder M.P.,
RA Mukherjee S., Bassik M.C.;
RT "Systematic Identification of Host Cell Regulators of Legionella
RT pneumophila Pathogenesis Using a Genome-wide CRISPR Screen.";
RL Cell Host Microbe 26:551.E6-563.E6(2019).
CC -!- FUNCTION: General regulator of phagocytosis. Required to uptake Gram
CC negative bacterium by macrophages. {ECO:0000269|PubMed:31540829}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q9BWL3}.
CC Mitochondrion {ECO:0000250|UniProtKB:Q9BWL3}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8R092-3; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R092-1; Sequence=VSP_014423, VSP_014424;
CC Name=3;
CC IsoId=Q8R092-2; Sequence=VSP_014422;
CC -!- DOMAIN: N-terminal region is required for phagocytosis of Gram negative
CC bacterium. {ECO:0000250|UniProtKB:Q9BWL3}.
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DR EMBL; AY533135; AAS21302.1; -; mRNA.
DR EMBL; AK009362; BAB26242.1; -; mRNA.
DR EMBL; AK017833; BAB30964.2; -; mRNA.
DR EMBL; AK034749; BAC28820.1; -; mRNA.
DR EMBL; AK051238; BAC34568.1; -; mRNA.
DR EMBL; AK077215; BAC36688.1; -; mRNA.
DR EMBL; AK151002; BAE30026.1; -; mRNA.
DR EMBL; BC022598; AAH22598.1; -; mRNA.
DR EMBL; BC027190; AAH27190.1; -; mRNA.
DR CCDS; CCDS17520.1; -. [Q8R092-3]
DR CCDS; CCDS50967.1; -. [Q8R092-2]
DR RefSeq; NP_001274016.1; NM_001287087.1. [Q8R092-3]
DR RefSeq; NP_080038.1; NM_025762.3. [Q8R092-3]
DR RefSeq; NP_081776.2; NM_027500.4. [Q8R092-2]
DR AlphaFoldDB; Q8R092; -.
DR STRING; 10090.ENSMUSP00000124028; -.
DR iPTMnet; Q8R092; -.
DR PhosphoSitePlus; Q8R092; -.
DR MaxQB; Q8R092; -.
DR PaxDb; Q8R092; -.
DR PRIDE; Q8R092; -.
DR DNASU; 99650; -.
DR Ensembl; ENSMUST00000029552; ENSMUSP00000029552; ENSMUSG00000027942. [Q8R092-2]
DR Ensembl; ENSMUST00000159064; ENSMUSP00000124554; ENSMUSG00000027942. [Q8R092-3]
DR Ensembl; ENSMUST00000160640; ENSMUSP00000124028; ENSMUSG00000027942. [Q8R092-3]
DR Ensembl; ENSMUST00000162114; ENSMUSP00000124822; ENSMUSG00000027942. [Q8R092-1]
DR Ensembl; ENSMUST00000239076; ENSMUSP00000159150; ENSMUSG00000118504. [Q8R092-3]
DR GeneID; 99650; -.
DR KEGG; mmu:99650; -.
DR UCSC; uc008qba.3; mouse. [Q8R092-3]
DR UCSC; uc008qbb.3; mouse. [Q8R092-1]
DR MGI; MGI:1914027; 4933434E20Rik.
DR VEuPathDB; HostDB:ENSMUSG00000027942; -.
DR VEuPathDB; HostDB:ENSMUSG00000118504; -.
DR eggNOG; ENOG502QUKH; Eukaryota.
DR GeneTree; ENSGT00510000047366; -.
DR HOGENOM; CLU_068266_0_0_1; -.
DR InParanoid; Q8R092; -.
DR OMA; QHAKVNM; -.
DR OrthoDB; 1581753at2759; -.
DR PhylomeDB; Q8R092; -.
DR TreeFam; TF324880; -.
DR BioGRID-ORCS; 99650; 4 hits in 74 CRISPR screens.
DR PRO; PR:Q8R092; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8R092; protein.
DR Bgee; ENSMUSG00000027942; Expressed in quadriceps femoris and 60 other tissues.
DR ExpressionAtlas; Q8R092; baseline and differential.
DR Genevisible; Q8R092; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:0006909; P:phagocytosis; IMP:UniProtKB.
DR InterPro; IPR010876; C1orf43.
DR PANTHER; PTHR21425; PTHR21425; 1.
DR Pfam; PF07406; NICE-3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Golgi apparatus; Membrane; Mitochondrion;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..253
FT /note="Protein C1orf43 homolog"
FT /id="PRO_0000089257"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 190..253
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014422"
FT VAR_SEQ 190..199
FT /note="VKARIGSSQR -> FTYFMYMSTL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014423"
FT VAR_SEQ 200..253
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014424"
FT CONFLICT 4
FT /note="S -> N (in Ref. 2; BAB30964/BAC28820)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="A -> S (in Ref. 2; BAB26242)"
FT /evidence="ECO:0000305"
FT CONFLICT 203
FT /note="S -> A (in Ref. 2; BAC34568)"
FT /evidence="ECO:0000305"
FT CONFLICT 242
FT /note="F -> L (in Ref. 3; AAH22598)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 253 AA; 28691 MW; 610A1138B9F03569 CRC64;
MASSSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV GHNAPKDLKE
EIDIRLSRVQ DIKYEPQLLA DDDTRLLQLE TQGNQSCYNY LYRMKALDAI RASEIPFHAE
GRHPCSLMGK NFRSYLLDLR NTSTPFKGVG KALIDTLLDG YETARYGTGV FGQSEYLRYQ
EALSELATVV KARIGSSQRQ HQSAAKDLTQ SPEMSPTTIQ VTYLPSSQKS KRPKHFLELK
SFKDNYNTLE STL
