UBTD1_HUMAN
ID UBTD1_HUMAN Reviewed; 227 AA.
AC Q9HAC8; D3DR57; Q53HI3;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Ubiquitin domain-containing protein 1;
GN Name=UBTD1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Coronary artery;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INTERACTION WITH UBE2D3.
RX PubMed=24211586; DOI=10.1016/j.bbrc.2013.10.137;
RA Uhler J.P., Spaahr H., Farge G., Clavel S., Larsson N.G., Falkenberg M.,
RA Samuelsson T., Gustafsson C.M.;
RT "The UbL protein UBTD1 stably interacts with the UBE2D family of E2
RT ubiquitin conjugating enzymes.";
RL Biochem. Biophys. Res. Commun. 443:7-12(2014).
RN [7]
RP FUNCTION, AND INDUCTION BY CYTOTOXIC AGENTS.
RX PubMed=25382750; DOI=10.1002/path.4478;
RA Zhang X.W., Wang X.F., Ni S.J., Qin W., Zhao L.Q., Hua R.X., Lu Y.W.,
RA Li J., Dimri G.P., Guo W.J.;
RT "UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive
RT feedback loop.";
RL J. Pathol. 235:656-667(2015).
CC -!- FUNCTION: May be involved in the regulation of cellular senescence
CC through a positive feedback loop with TP53. Is a TP53 downstream target
CC gene that increases the stability of TP53 protein by promoting the
CC ubiquitination and degradation of MDM2. {ECO:0000269|PubMed:25382750}.
CC -!- SUBUNIT: Interacts with UBTD1. {ECO:0000269|PubMed:24211586}.
CC -!- INTERACTION:
CC Q9HAC8; O15344: MID1; NbExp=6; IntAct=EBI-745871, EBI-2340316;
CC Q9HAC8; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-745871, EBI-10172526;
CC Q9HAC8; Q9Y605: MRFAP1; NbExp=5; IntAct=EBI-745871, EBI-995714;
CC Q9HAC8; Q96HT8: MRFAP1L1; NbExp=8; IntAct=EBI-745871, EBI-748896;
CC Q9HAC8; Q99942: RNF5; NbExp=5; IntAct=EBI-745871, EBI-348482;
CC Q9HAC8; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-745871, EBI-11952721;
CC Q9HAC8; Q9Y4K3: TRAF6; NbExp=3; IntAct=EBI-745871, EBI-359276;
CC Q9HAC8; Q9HCM9: TRIM39; NbExp=4; IntAct=EBI-745871, EBI-739510;
CC Q9HAC8; Q9HCM9-2: TRIM39; NbExp=5; IntAct=EBI-745871, EBI-11523450;
CC Q9HAC8; Q86XT4: TRIM50; NbExp=3; IntAct=EBI-745871, EBI-9867283;
CC Q9HAC8; P51668: UBE2D1; NbExp=3; IntAct=EBI-745871, EBI-743540;
CC Q9HAC8; P62837: UBE2D2; NbExp=7; IntAct=EBI-745871, EBI-347677;
CC Q9HAC8; P61077: UBE2D3; NbExp=6; IntAct=EBI-745871, EBI-348268;
CC Q9HAC8; Q9Y2X8: UBE2D4; NbExp=9; IntAct=EBI-745871, EBI-745527;
CC Q9HAC8; O00308: WWP2; NbExp=3; IntAct=EBI-745871, EBI-743923;
CC -!- INDUCTION: Induced by cytotoxic agents, it is also increased during
CC premature senescence. the induction seems to be mediated by TP53.
CC {ECO:0000269|PubMed:24211586}.
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DR EMBL; AK021869; BAB13921.1; -; mRNA.
DR EMBL; AK222597; BAD96317.1; -; mRNA.
DR EMBL; AL359388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471066; EAW49918.1; -; Genomic_DNA.
DR EMBL; CH471066; EAW49919.1; -; Genomic_DNA.
DR EMBL; BC007331; AAH07331.1; -; mRNA.
DR CCDS; CCDS7465.1; -.
DR RefSeq; NP_079230.1; NM_024954.4.
DR AlphaFoldDB; Q9HAC8; -.
DR SMR; Q9HAC8; -.
DR BioGRID; 123073; 41.
DR IntAct; Q9HAC8; 20.
DR STRING; 9606.ENSP00000359698; -.
DR iPTMnet; Q9HAC8; -.
DR PhosphoSitePlus; Q9HAC8; -.
DR SwissPalm; Q9HAC8; -.
DR BioMuta; UBTD1; -.
DR DMDM; 74752759; -.
DR EPD; Q9HAC8; -.
DR jPOST; Q9HAC8; -.
DR MassIVE; Q9HAC8; -.
DR MaxQB; Q9HAC8; -.
DR PaxDb; Q9HAC8; -.
DR PeptideAtlas; Q9HAC8; -.
DR PRIDE; Q9HAC8; -.
DR ProteomicsDB; 81395; -.
DR Antibodypedia; 30969; 325 antibodies from 28 providers.
DR DNASU; 80019; -.
DR Ensembl; ENST00000370664.4; ENSP00000359698.3; ENSG00000165886.5.
DR GeneID; 80019; -.
DR KEGG; hsa:80019; -.
DR MANE-Select; ENST00000370664.4; ENSP00000359698.3; NM_024954.5; NP_079230.1.
DR UCSC; uc001knv.2; human.
DR CTD; 80019; -.
DR DisGeNET; 80019; -.
DR GeneCards; UBTD1; -.
DR HGNC; HGNC:25683; UBTD1.
DR HPA; ENSG00000165886; Low tissue specificity.
DR MIM; 616388; gene.
DR neXtProt; NX_Q9HAC8; -.
DR OpenTargets; ENSG00000165886; -.
DR PharmGKB; PA134976337; -.
DR VEuPathDB; HostDB:ENSG00000165886; -.
DR eggNOG; KOG0013; Eukaryota.
DR GeneTree; ENSGT00940000158630; -.
DR HOGENOM; CLU_070348_0_0_1; -.
DR InParanoid; Q9HAC8; -.
DR OMA; AWQRWFF; -.
DR OrthoDB; 1221075at2759; -.
DR PhylomeDB; Q9HAC8; -.
DR TreeFam; TF323925; -.
DR PathwayCommons; Q9HAC8; -.
DR SignaLink; Q9HAC8; -.
DR BioGRID-ORCS; 80019; 11 hits in 1076 CRISPR screens.
DR ChiTaRS; UBTD1; human.
DR GenomeRNAi; 80019; -.
DR Pharos; Q9HAC8; Tdark.
DR PRO; PR:Q9HAC8; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q9HAC8; protein.
DR Bgee; ENSG00000165886; Expressed in left testis and 135 other tissues.
DR Genevisible; Q9HAC8; HS.
DR Gene3D; 1.20.225.20; -; 1.
DR InterPro; IPR032752; DC-UbP/UBTD2_N.
DR InterPro; IPR038169; DC-UbP/UBTD2_N_sf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019956; Ubiquitin_dom.
DR InterPro; IPR039869; UBTD1/2.
DR PANTHER; PTHR13609; PTHR13609; 1.
DR Pfam; PF16455; UBD; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR PRINTS; PR00348; UBIQUITIN.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..227
FT /note="Ubiquitin domain-containing protein 1"
FT /id="PRO_0000242674"
FT DOMAIN 149..224
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 133
FT /note="E -> G (in Ref. 2; BAD96317)"
FT /evidence="ECO:0000305"
FT CONFLICT 173
FT /note="Q -> L (in Ref. 2; BAD96317)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 227 AA; 25938 MW; 7D34DB6027797255 CRC64;
MGNCVGRQRR ERPAAPGHPR KRAGRNEPLK KERLKWKSDY PMTDGQLRSK RDEFWDTAPA
FEGRKEIWDA LKAAAYAAEA NDHELAQAIL DGASITLPHG TLCECYDELG NRYQLPIYCL
SPPVNLLLEH TEEESLEPPE PPPSVRREFP LKVRLSTGKD VRLSASLPDT VGQLKRQLHA
QEGIEPSWQR WFFSGKLLTD RTRLQETKIQ KDFVIQVIIN QPPPPQD
