UBTD1_MOUSE
ID UBTD1_MOUSE Reviewed; 227 AA.
AC Q91WB7;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Ubiquitin domain-containing protein 1;
GN Name=Ubtd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Muellerian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in the regulation of cellular senescence
CC through a positive feedback loop with TP53. Is a TP53 downstream target
CC gene that increases the stability of TP53 protein by promoting the
CC ubiquitination and degradation of MDM2. {ECO:0000250|UniProtKB:Q9HAC8}.
CC -!- SUBUNIT: Interacts with UBTD1. {ECO:0000250|UniProtKB:Q9HAC8}.
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DR EMBL; AK078479; BAC37298.1; -; mRNA.
DR EMBL; BC016129; AAH16129.1; -; mRNA.
DR CCDS; CCDS29819.1; -.
DR RefSeq; NP_663475.1; NM_145500.3.
DR AlphaFoldDB; Q91WB7; -.
DR SMR; Q91WB7; -.
DR STRING; 10090.ENSMUSP00000026170; -.
DR iPTMnet; Q91WB7; -.
DR PhosphoSitePlus; Q91WB7; -.
DR SwissPalm; Q91WB7; -.
DR EPD; Q91WB7; -.
DR MaxQB; Q91WB7; -.
DR PaxDb; Q91WB7; -.
DR PeptideAtlas; Q91WB7; -.
DR PRIDE; Q91WB7; -.
DR ProteomicsDB; 298424; -.
DR Antibodypedia; 30969; 325 antibodies from 28 providers.
DR DNASU; 226122; -.
DR Ensembl; ENSMUST00000026170; ENSMUSP00000026170; ENSMUSG00000025171.
DR GeneID; 226122; -.
DR KEGG; mmu:226122; -.
DR UCSC; uc008hmz.1; mouse.
DR CTD; 80019; -.
DR MGI; MGI:2385092; Ubtd1.
DR VEuPathDB; HostDB:ENSMUSG00000025171; -.
DR eggNOG; KOG0013; Eukaryota.
DR GeneTree; ENSGT00940000158630; -.
DR HOGENOM; CLU_070348_0_0_1; -.
DR InParanoid; Q91WB7; -.
DR OMA; AWQRWFF; -.
DR OrthoDB; 1221075at2759; -.
DR PhylomeDB; Q91WB7; -.
DR TreeFam; TF323925; -.
DR BioGRID-ORCS; 226122; 4 hits in 74 CRISPR screens.
DR ChiTaRS; Ubtd1; mouse.
DR PRO; PR:Q91WB7; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q91WB7; protein.
DR Bgee; ENSMUSG00000025171; Expressed in spermatid and 125 other tissues.
DR Genevisible; Q91WB7; MM.
DR Gene3D; 1.20.225.20; -; 1.
DR InterPro; IPR032752; DC-UbP/UBTD2_N.
DR InterPro; IPR038169; DC-UbP/UBTD2_N_sf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019956; Ubiquitin_dom.
DR InterPro; IPR039869; UBTD1/2.
DR PANTHER; PTHR13609; PTHR13609; 1.
DR Pfam; PF16455; UBD; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR PRINTS; PR00348; UBIQUITIN.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..227
FT /note="Ubiquitin domain-containing protein 1"
FT /id="PRO_0000242675"
FT DOMAIN 149..224
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 227 AA; 25985 MW; 2C80D125D77E18F2 CRC64;
MGNCVGRQRR ERPAAPGHPR KRAGRNEPLK KERLKWKSDY PMTDGQLRSK RDEFWDTAPA
FEGRKEIWDA LKAAAYAAEA NDHELAQAIL DGASITLPHG TLCECYDELG NRYQLPIYCL
SPPVNLLLEH TEEESLEPPE PTPSVRREFP LKVRLSTGKD VRLNASLPDT VGQLKRQLHS
QEGIEPSWQR WFFSGKLLTD RTRLQETKIQ KDFVIQVIIN QPPPPQD
