ID   UBTD1_RAT               Reviewed;         227 AA.
AC   Q68FV8;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Ubiquitin domain-containing protein 1;
GN   Name=Ubtd1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in the regulation of cellular senescence
CC       through a positive feedback loop with TP53. Is a TP53 downstream target
CC       gene that increases the stability of TP53 protein by promoting the
CC       ubiquitination and degradation of MDM2. {ECO:0000250|UniProtKB:Q9HAC8}.
CC   -!- SUBUNIT: Interacts with UBTD1. {ECO:0000250|UniProtKB:Q9HAC8}.
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DR   EMBL; BC079260; AAH79260.1; -; mRNA.
DR   RefSeq; NP_001013171.1; NM_001013153.1.
DR   AlphaFoldDB; Q68FV8; -.
DR   SMR; Q68FV8; -.
DR   STRING; 10116.ENSRNOP00000018485; -.
DR   PaxDb; Q68FV8; -.
DR   PRIDE; Q68FV8; -.
DR   Ensembl; ENSRNOT00000018485; ENSRNOP00000018485; ENSRNOG00000013813.
DR   GeneID; 309373; -.
DR   KEGG; rno:309373; -.
DR   UCSC; RGD:1308172; rat.
DR   CTD; 80019; -.
DR   RGD; 1308172; Ubtd1.
DR   eggNOG; KOG0013; Eukaryota.
DR   GeneTree; ENSGT00940000158630; -.
DR   HOGENOM; CLU_070348_0_0_1; -.
DR   InParanoid; Q68FV8; -.
DR   OMA; AWQRWFF; -.
DR   OrthoDB; 1221075at2759; -.
DR   PhylomeDB; Q68FV8; -.
DR   PRO; PR:Q68FV8; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000013813; Expressed in testis and 19 other tissues.
DR   Genevisible; Q68FV8; RN.
DR   Gene3D; 1.20.225.20; -; 1.
DR   InterPro; IPR032752; DC-UbP/UBTD2_N.
DR   InterPro; IPR038169; DC-UbP/UBTD2_N_sf.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR019956; Ubiquitin_dom.
DR   InterPro; IPR039869; UBTD1/2.
DR   PANTHER; PTHR13609; PTHR13609; 1.
DR   Pfam; PF16455; UBD; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..227
FT                   /note="Ubiquitin domain-containing protein 1"
FT                   /id="PRO_0000242676"
FT   DOMAIN          149..224
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   227 AA;  25958 MW;  3D70C0C4277E18EF CRC64;
     MGNCVGRQRR ERPAAPGHPR KRAGRNEPLK KERLKWKSDY PMTDGQLRSK RDEFWDTAPA
     FEGRKEIWDA LKAAAYAAEA NDHELAQAIL DGASITLPHG TLCECYDELG NRYQLPIYCL
     SPPVNLLLEH TEEESLEPPE PTPSVRREFP LKVRLSTGKD VRLSASLPDT VGQLKRQLHS
     QEGIEPSWQR WFFSGKLLTD RTRLQETKIQ KDFVIQVIIN QPPPPQD