UBTD2_HUMAN
ID UBTD2_HUMAN Reviewed; 234 AA.
AC Q8WUN7; Q8TDQ3;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Ubiquitin domain-containing protein 2;
DE AltName: Full=Dendritic cell-derived ubiquitin-like protein;
DE Short=DC-UbP;
DE AltName: Full=Ubiquitin-like protein SB72;
GN Name=UBTD2; Synonyms=DCUBP; ORFNames=SB72;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-234.
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 122-234, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Dendritic cell;
RX PubMed=12507522; DOI=10.1016/s0006-291x(02)02913-3;
RA Liu S., An H., Li N., Yu Y., Lin N., Wan T., Zhang M., Wang W., Cao X.;
RT "Cloning and identification of a novel human ubiquitin-like protein, DC-
RT UbP, from dendritic cells.";
RL Biochem. Biophys. Res. Commun. 300:800-805(2003).
RN [4]
RP STRUCTURE BY NMR OF 129-234.
RX PubMed=15987890; DOI=10.1110/ps.051455505;
RA Gao Y.-G., Song A.-X., Shi Y.-H., Chang Y.-G., Liu S.-X., Yu Y.-Z.,
RA Cao X.-T., Lin D.-H., Hu H.-Y.;
RT "Solution structure of the ubiquitin-like domain of human DC-UbP from
RT dendritic cells.";
RL Protein Sci. 14:2044-2050(2005).
CC -!- INTERACTION:
CC Q8WUN7; Q13520: AQP6; NbExp=3; IntAct=EBI-12867288, EBI-13059134;
CC Q8WUN7; Q03989: ARID5A; NbExp=3; IntAct=EBI-12867288, EBI-948603;
CC Q8WUN7; P07902: GALT; NbExp=4; IntAct=EBI-12867288, EBI-750827;
CC Q8WUN7; Q13227: GPS2; NbExp=3; IntAct=EBI-12867288, EBI-713355;
CC Q8WUN7; Q0VD86: INCA1; NbExp=3; IntAct=EBI-12867288, EBI-6509505;
CC Q8WUN7; Q6PF15: KLHL35; NbExp=3; IntAct=EBI-12867288, EBI-9477654;
CC Q8WUN7; Q9NRX2: MRPL17; NbExp=3; IntAct=EBI-12867288, EBI-7825154;
CC Q8WUN7; Q14764: MVP; NbExp=3; IntAct=EBI-12867288, EBI-2816254;
CC Q8WUN7; P78317: RNF4; NbExp=3; IntAct=EBI-12867288, EBI-2340927;
CC Q8WUN7; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-12867288, EBI-492476;
CC Q8WUN7; Q9Y2X8: UBE2D4; NbExp=3; IntAct=EBI-12867288, EBI-745527;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12507522}.
CC -!- TISSUE SPECIFICITY: Detected in dendritic cells. Highly expressed in
CC tumor cell lines, but not detectable in most tissues.
CC {ECO:0000269|PubMed:12507522}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH19910.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL99389.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC008671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC024561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC019910; AAH19910.1; ALT_INIT; mRNA.
DR EMBL; AF251700; AAL99389.1; ALT_INIT; mRNA.
DR CCDS; CCDS4379.2; -.
DR RefSeq; NP_689490.2; NM_152277.2.
DR RefSeq; XP_016865511.1; XM_017010022.1.
DR RefSeq; XP_016865512.1; XM_017010023.1.
DR PDB; 1TTN; NMR; -; A=129-234.
DR PDB; 2KSN; NMR; -; A=14-141.
DR PDBsum; 1TTN; -.
DR PDBsum; 2KSN; -.
DR AlphaFoldDB; Q8WUN7; -.
DR BMRB; Q8WUN7; -.
DR SMR; Q8WUN7; -.
DR BioGRID; 124917; 26.
DR IntAct; Q8WUN7; 20.
DR STRING; 9606.ENSP00000377381; -.
DR iPTMnet; Q8WUN7; -.
DR PhosphoSitePlus; Q8WUN7; -.
DR SwissPalm; Q8WUN7; -.
DR BioMuta; UBTD2; -.
DR DMDM; 109896149; -.
DR EPD; Q8WUN7; -.
DR jPOST; Q8WUN7; -.
DR MassIVE; Q8WUN7; -.
DR MaxQB; Q8WUN7; -.
DR PaxDb; Q8WUN7; -.
DR PeptideAtlas; Q8WUN7; -.
DR PRIDE; Q8WUN7; -.
DR ProteomicsDB; 74697; -.
DR Antibodypedia; 28892; 189 antibodies from 28 providers.
DR DNASU; 92181; -.
DR Ensembl; ENST00000393792.3; ENSP00000377381.2; ENSG00000168246.6.
DR GeneID; 92181; -.
DR KEGG; hsa:92181; -.
DR MANE-Select; ENST00000393792.3; ENSP00000377381.2; NM_152277.3; NP_689490.2.
DR UCSC; uc003mbp.2; human.
DR CTD; 92181; -.
DR GeneCards; UBTD2; -.
DR HGNC; HGNC:24463; UBTD2.
DR HPA; ENSG00000168246; Low tissue specificity.
DR MIM; 610174; gene.
DR neXtProt; NX_Q8WUN7; -.
DR OpenTargets; ENSG00000168246; -.
DR PharmGKB; PA162408325; -.
DR VEuPathDB; HostDB:ENSG00000168246; -.
DR eggNOG; KOG0013; Eukaryota.
DR GeneTree; ENSGT00940000156641; -.
DR HOGENOM; CLU_070348_0_0_1; -.
DR InParanoid; Q8WUN7; -.
DR OMA; GTGGECQ; -.
DR OrthoDB; 1221075at2759; -.
DR PhylomeDB; Q8WUN7; -.
DR TreeFam; TF323925; -.
DR PathwayCommons; Q8WUN7; -.
DR SignaLink; Q8WUN7; -.
DR BioGRID-ORCS; 92181; 5 hits in 1067 CRISPR screens.
DR ChiTaRS; UBTD2; human.
DR EvolutionaryTrace; Q8WUN7; -.
DR GenomeRNAi; 92181; -.
DR Pharos; Q8WUN7; Tbio.
DR PRO; PR:Q8WUN7; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8WUN7; protein.
DR Bgee; ENSG00000168246; Expressed in secondary oocyte and 192 other tissues.
DR Genevisible; Q8WUN7; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR DisProt; DP02694; -.
DR Gene3D; 1.20.225.20; -; 1.
DR InterPro; IPR032752; DC-UbP/UBTD2_N.
DR InterPro; IPR038169; DC-UbP/UBTD2_N_sf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR039869; UBTD1/2.
DR PANTHER; PTHR13609; PTHR13609; 1.
DR Pfam; PF16455; UBD; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome.
FT CHAIN 1..234
FT /note="Ubiquitin domain-containing protein 2"
FT /id="PRO_0000244332"
FT DOMAIN 152..227
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 129
FT /note="M -> I (in dbSNP:rs17074452)"
FT /id="VAR_052694"
FT STRAND 21..23
FT /evidence="ECO:0007829|PDB:2KSN"
FT HELIX 47..58
FT /evidence="ECO:0007829|PDB:2KSN"
FT HELIX 68..82
FT /evidence="ECO:0007829|PDB:2KSN"
FT HELIX 86..96
FT /evidence="ECO:0007829|PDB:2KSN"
FT STRAND 105..110
FT /evidence="ECO:0007829|PDB:2KSN"
FT TURN 111..113
FT /evidence="ECO:0007829|PDB:2KSN"
FT STRAND 114..117
FT /evidence="ECO:0007829|PDB:2KSN"
FT HELIX 120..122
FT /evidence="ECO:0007829|PDB:2KSN"
FT TURN 127..129
FT /evidence="ECO:0007829|PDB:2KSN"
FT TURN 133..135
FT /evidence="ECO:0007829|PDB:2KSN"
FT STRAND 151..158
FT /evidence="ECO:0007829|PDB:1TTN"
FT TURN 159..161
FT /evidence="ECO:0007829|PDB:1TTN"
FT STRAND 162..168
FT /evidence="ECO:0007829|PDB:1TTN"
FT HELIX 173..183
FT /evidence="ECO:0007829|PDB:1TTN"
FT STRAND 193..196
FT /evidence="ECO:0007829|PDB:1TTN"
FT HELIX 206..209
FT /evidence="ECO:0007829|PDB:1TTN"
FT STRAND 213..215
FT /evidence="ECO:0007829|PDB:1TTN"
FT STRAND 217..221
FT /evidence="ECO:0007829|PDB:1TTN"
SQ SEQUENCE 234 AA; 26190 MW; 9FB195CDDE83583E CRC64;
MGGCVGAQHD SSGSLNENSE GTGVALGRNQ PLKKEKPKWK SDYPMTDGQL RSKRDEFWDT
APAFEGRKEI WDALKAAAHA FESNDHELAQ AIIDGANITL PHGALTECYD ELGNRYQLPV
YCLAPPINMI EEKSDIETLD IPEPPPNSGY ECQLRLRLST GKDLKLVVRS TDTVFHMKRR
LHAAEGVEPG SQRWFFSGRP LTDKMKFEEL KIPKDYVVQV IVSQPVQNPT PVEN
