UBTD2_MOUSE
ID UBTD2_MOUSE Reviewed; 234 AA.
AC Q6PGH0; A2AAY6; Q8C5Y1;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Ubiquitin domain-containing protein 2;
GN Name=Ubtd2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AK076953; BAC36536.1; -; mRNA.
DR EMBL; AL662780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL669844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057026; AAH57026.1; -; mRNA.
DR CCDS; CCDS24527.1; -.
DR RefSeq; NP_776145.2; NM_173784.3.
DR AlphaFoldDB; Q6PGH0; -.
DR SMR; Q6PGH0; -.
DR STRING; 10090.ENSMUSP00000056765; -.
DR iPTMnet; Q6PGH0; -.
DR PhosphoSitePlus; Q6PGH0; -.
DR SwissPalm; Q6PGH0; -.
DR MaxQB; Q6PGH0; -.
DR PaxDb; Q6PGH0; -.
DR PeptideAtlas; Q6PGH0; -.
DR PRIDE; Q6PGH0; -.
DR ProteomicsDB; 298113; -.
DR Antibodypedia; 28892; 189 antibodies from 28 providers.
DR DNASU; 327900; -.
DR Ensembl; ENSMUST00000051053; ENSMUSP00000056765; ENSMUSG00000044949.
DR GeneID; 327900; -.
DR KEGG; mmu:327900; -.
DR UCSC; uc007ijr.1; mouse.
DR CTD; 92181; -.
DR MGI; MGI:2444752; Ubtd2.
DR VEuPathDB; HostDB:ENSMUSG00000044949; -.
DR eggNOG; KOG0013; Eukaryota.
DR GeneTree; ENSGT00940000156641; -.
DR HOGENOM; CLU_070348_0_0_1; -.
DR InParanoid; Q6PGH0; -.
DR OMA; GTGGECQ; -.
DR OrthoDB; 1221075at2759; -.
DR PhylomeDB; Q6PGH0; -.
DR TreeFam; TF323925; -.
DR BioGRID-ORCS; 327900; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Ubtd2; mouse.
DR PRO; PR:Q6PGH0; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q6PGH0; protein.
DR Bgee; ENSMUSG00000044949; Expressed in embryonic post-anal tail and 70 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.225.20; -; 1.
DR InterPro; IPR032752; DC-UbP/UBTD2_N.
DR InterPro; IPR038169; DC-UbP/UBTD2_N_sf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR039869; UBTD1/2.
DR PANTHER; PTHR13609; PTHR13609; 1.
DR Pfam; PF16455; UBD; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..234
FT /note="Ubiquitin domain-containing protein 2"
FT /id="PRO_0000244333"
FT DOMAIN 152..227
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 13
FT /note="G -> D (in Ref. 1; BAC36536)"
FT /evidence="ECO:0000305"
FT CONFLICT 187
FT /note="V -> L (in Ref. 1; BAC36536)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 234 AA; 26144 MW; 3A980ECD7EE97CEE CRC64;
MGGCVGAQHD SSGSLNENSD GTGVALGRNQ PLKKEKPKWK SDYPMTDGQL RSKRDEFWDT
APAFEGRKEI WDALKAAAHA FESNDHELAQ AIIDGANITL PHGALTECYD ELGNRYQLPV
YCLAPPINMI EEKSDIETLD IPEPPPNSGH ESQLRLRLST GKDLRLVVRS TDTVFHMKRR
LHATEGVEPG SQRWFFSGRP LTDKMKLEEL KIPKDYVVQV IVSQPVQTPT PVEN
