ID   CA043_PONAB             Reviewed;         189 AA.
AC   Q5RF08;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Protein C1orf43 homolog;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: General regulator of phagocytosis. Required to uptake Gram
CC       negative bacterium by macrophages. {ECO:0000250|UniProtKB:Q9BWL3}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q9BWL3}.
CC       Mitochondrion {ECO:0000250|UniProtKB:Q9BWL3}.
CC   -!- DOMAIN: N-terminal region is required for phagocytosis of Gram negative
CC       bacterium. {ECO:0000250|UniProtKB:Q9BWL3}.
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DR   EMBL; CR857353; CAH89649.1; -; mRNA.
DR   RefSeq; NP_001124740.1; NM_001131268.2.
DR   AlphaFoldDB; Q5RF08; -.
DR   SMR; Q5RF08; -.
DR   STRING; 9601.ENSPPYP00000000916; -.
DR   PRIDE; Q5RF08; -.
DR   GeneID; 100171589; -.
DR   KEGG; pon:100171589; -.
DR   CTD; 118223182; -.
DR   eggNOG; ENOG502QUKH; Eukaryota.
DR   HOGENOM; CLU_068266_0_0_1; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0006909; P:phagocytosis; ISS:UniProtKB.
DR   InterPro; IPR010876; C1orf43.
DR   PANTHER; PTHR21425; PTHR21425; 1.
DR   Pfam; PF07406; NICE-3; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Mitochondrion; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..189
FT                   /note="Protein C1orf43 homolog"
FT                   /id="PRO_0000089258"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   189 AA;  21582 MW;  2115AE1540F8A227 CRC64;
     MASGSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV GHNAPKDLKE
     EIDIRLSRVQ DIKYEPQLLA DDDARLLQLE TQGNQSCYNY LYRMKALDAI RTSEIPFHSE
     GRHPRSLMGK NFRSYLLDLR NTSTPFKGVR KALIDTLLDG YETARYGTGV FGQNEYLRYQ
     EALSELATA