ID   UBX10_DANRE             Reviewed;         214 AA.
AC   Q0P3Z8;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=UBX domain-containing protein 10 {ECO:0000305};
GN   Name=ubxn10 {ECO:0000312|ZFIN:ZDB-GENE-060825-319};
GN   ORFNames=zgc:153648 {ECO:0000303|Ref.2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Intestine;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=26389662; DOI=10.1038/ncb3238;
RA   Raman M., Sergeev M., Garnaas M., Lydeard J.R., Huttlin E.L., Goessling W.,
RA   Shah J.V., Harper J.W.;
RT   "Systematic proteomics of the VCP-UBXD adaptor network identifies a role
RT   for UBXN10 in regulating ciliogenesis.";
RL   Nat. Cell Biol. 17:1356-1369(2015).
CC   -!- FUNCTION: Required for ciliogenesis (PubMed:26389662). Acts as a
CC       tethering factor that facilitates recruitment of vcp/p97 to the
CC       intraflagellar transport complex B (IFT-B) in cilia (By similarity).
CC       {ECO:0000250|UniProtKB:Q96LJ8, ECO:0000269|PubMed:26389662}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q96LJ8}.
CC   -!- DISRUPTION PHENOTYPE: Defects in left-right asymmetry during
CC       embryogenesis, due to defects in ciliogenesis.
CC       {ECO:0000269|PubMed:23594743}.
CC   -!- SIMILARITY: Belongs to the UBXN10 family. {ECO:0000305}.
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DR   EMBL; CR846089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC122361; AAI22362.1; -; mRNA.
DR   RefSeq; NP_001038911.1; NM_001045446.2.
DR   RefSeq; XP_017209098.1; XM_017353609.1.
DR   AlphaFoldDB; Q0P3Z8; -.
DR   SMR; Q0P3Z8; -.
DR   STRING; 7955.ENSDARP00000068895; -.
DR   PaxDb; Q0P3Z8; -.
DR   Ensembl; ENSDART00000074406; ENSDARP00000068895; ENSDARG00000052535.
DR   GeneID; 751736; -.
DR   KEGG; dre:751736; -.
DR   CTD; 127733; -.
DR   ZFIN; ZDB-GENE-060825-319; ubxn10.
DR   eggNOG; ENOG502S4IN; Eukaryota.
DR   GeneTree; ENSGT00390000012939; -.
DR   HOGENOM; CLU_079919_0_0_1; -.
DR   InParanoid; Q0P3Z8; -.
DR   OMA; ECRIPHK; -.
DR   OrthoDB; 1474017at2759; -.
DR   PhylomeDB; Q0P3Z8; -.
DR   TreeFam; TF335927; -.
DR   PRO; PR:Q0P3Z8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000052535; Expressed in testis and 7 other tissues.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0061371; P:determination of heart left/right asymmetry; IMP:ZFIN.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR001012; UBX_dom.
DR   Pfam; PF00789; UBX; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50033; UBX; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Reference proteome.
FT   CHAIN           1..214
FT                   /note="UBX domain-containing protein 10"
FT                   /id="PRO_0000440624"
FT   DOMAIN          127..204
FT                   /note="UBX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   214 AA;  23939 MW;  3C925CFD26D1528C CRC64;
     MHVTRPKSSK GRSRPMITNS SMIYTPSQPS ALSPQPPAAA KTKDKSNQSL RSRAILRRSS
     QPTTDILTEA YDRPPEEPVS LNRYRVLPSI EKKTSTDNQK CSQCVSRHRK CQHTNARLDV
     VSDSTPPEES DLLLAIRTPC GQRFKRSFRP SDQLKGVLSA AEAEFGDRFD NCIIETMDVP
     RRTFSNLTMT LAQCGVLNKS VLCISHDDSE MDLT