ID   UBX1A_XENLA             Reviewed;         296 AA.
AC   Q6IP50; Q3B8K6;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=UBX domain-containing protein 1-A;
DE   AltName: Full=SAPK substrate protein 1-A;
GN   Name=ubxn1-a; Synonyms=saks1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Embryo, and Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a complex required to couple deglycosylation and
CC       proteasome-mediated degradation of misfolded proteins in the
CC       endoplasmic reticulum that are retrotranslocated in the cytosol.
CC       Involved in ubiquitin-proteasome systems (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6IP50-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6IP50-2; Sequence=VSP_020350;
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DR   EMBL; BC072068; AAH72068.1; -; mRNA.
DR   EMBL; BC106269; AAI06270.1; -; mRNA.
DR   RefSeq; NP_001085388.1; NM_001091919.1. [Q6IP50-2]
DR   RefSeq; XP_018115063.1; XM_018259574.1. [Q6IP50-1]
DR   AlphaFoldDB; Q6IP50; -.
DR   SMR; Q6IP50; -.
DR   PRIDE; Q6IP50; -.
DR   DNASU; 443814; -.
DR   GeneID; 443814; -.
DR   KEGG; xla:443814; -.
DR   CTD; 443814; -.
DR   Xenbase; XB-GENE-6251745; ubxn1.S.
DR   OMA; TNHANGV; -.
DR   OrthoDB; 1297214at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 443814; Expressed in testis and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd14302; UBA_UBXN1; 1.
DR   InterPro; IPR015940; UBA.
DR   InterPro; IPR009060; UBA-like_sf.
DR   InterPro; IPR041923; UBA_UBXN1.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR001012; UBX_dom.
DR   Pfam; PF00627; UBA; 1.
DR   Pfam; PF00789; UBX; 1.
DR   SMART; SM00165; UBA; 1.
DR   SMART; SM00166; UBX; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50030; UBA; 1.
DR   PROSITE; PS50033; UBX; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..296
FT                   /note="UBX domain-containing protein 1-A"
FT                   /id="PRO_0000249000"
FT   DOMAIN          1..42
FT                   /note="UBA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT   DOMAIN          214..293
FT                   /note="UBX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT   REGION          43..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          87..177
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        56..82
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..134
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..180
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         61
FT                   /note="T -> TDTA (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_020350"
SQ   SEQUENCE   296 AA;  33425 MW;  DBA0D4451F276319 CRC64;
     MAECSTLESL IEMGFSSTRA EKALTATGNQ GIEPAMDWLV EHEDDPDIDE PSVVVPEGSS
     TDTADTTDTT DTTDTQGMDT SAERLPLTEE EKEKQTKRMM ELVAQKQNER EEREKKERIE
     QEKQRRKHGQ ELSAIKQKMQ EQEMQKAAED RRREKQEEKM ARERVREKIA RDKADRARRF
     GGASSEPISP PAETSIPATT PSPSSPVQEP PTKKEYDQCR IQVRLLDGSA LSQTFRAREQ
     LAAVRLYVEL NWPGGPPGPF SLLTSFPQRV FTEEDMEKPL QELGLVPTAV LIVAKK