ID   UBX1B_XENLA             Reviewed;         290 AA.
AC   Q6GLV4;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=UBX domain-containing protein 1-B;
DE   AltName: Full=SAPK substrate protein 1-B;
GN   Name=ubxn1-b; Synonyms=saks1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a complex required to couple deglycosylation and
CC       proteasome-mediated degradation of misfolded proteins in the
CC       endoplasmic reticulum that are retrotranslocated in the cytosol.
CC       Involved in ubiquitin-proteasome systems (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; BC074345; AAH74345.1; -; mRNA.
DR   RefSeq; NP_001086224.1; NM_001092755.1.
DR   RefSeq; XP_018112217.1; XM_018256728.1.
DR   AlphaFoldDB; Q6GLV4; -.
DR   SMR; Q6GLV4; -.
DR   DNASU; 444653; -.
DR   GeneID; 444653; -.
DR   KEGG; xla:444653; -.
DR   CTD; 444653; -.
DR   Xenbase; XB-GENE-979863; ubxn1.L.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 444653; Expressed in brain and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd14302; UBA_UBXN1; 1.
DR   InterPro; IPR015940; UBA.
DR   InterPro; IPR009060; UBA-like_sf.
DR   InterPro; IPR041923; UBA_UBXN1.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR001012; UBX_dom.
DR   Pfam; PF00627; UBA; 1.
DR   Pfam; PF00789; UBX; 1.
DR   SMART; SM00165; UBA; 1.
DR   SMART; SM00166; UBX; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50030; UBA; 1.
DR   PROSITE; PS50033; UBX; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..290
FT                   /note="UBX domain-containing protein 1-B"
FT                   /id="PRO_0000249001"
FT   DOMAIN          1..42
FT                   /note="UBA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT   DOMAIN          208..287
FT                   /note="UBX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT   REGION          44..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          81..171
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        57..76
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        78..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..174
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   290 AA;  32920 MW;  EAF88DF7A76807F7 CRC64;
     MADCSALESL IEMGFSPSRA EKALSATGNQ GIEPAMDWLV EHEDDPDIKE PSVVIPEDSG
     TDTTDTTDTQ AMDTSAERLP LTEEEKEKQT KRMMELIAQK QKEREEREKR ERIEQEKQRR
     KHGQELSAIK QRMQEQEMQK AAEDRRREKQ EERLARERVR EKIARDKADR ARKFGGAGSE
     PISPPAETSV PATAPSPSSP VQEPPTKKEY DQCRIQVRLL DGSALSQTFR AREQLAAVRL
     YVELNWPGGP PEPFSLLTSF PRRVFTEEDM EKPLQELGLV PTAVLIVAKK