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CA043_RAT
ID   CA043_RAT               Reviewed;         235 AA.
AC   Q5XII8;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Protein C1orf43 homolog;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: General regulator of phagocytosis. Required to uptake Gram
CC       negative bacterium by macrophages. {ECO:0000250|UniProtKB:Q9BWL3}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q9BWL3}.
CC       Mitochondrion {ECO:0000250|UniProtKB:Q9BWL3}.
CC   -!- DOMAIN: N-terminal region is required for phagocytosis of Gram negative
CC       bacterium. {ECO:0000250|UniProtKB:Q9BWL3}.
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DR   EMBL; BC083693; AAH83693.1; -; mRNA.
DR   RefSeq; NP_001014196.1; NM_001014174.1.
DR   AlphaFoldDB; Q5XII8; -.
DR   STRING; 10116.ENSRNOP00000046713; -.
DR   iPTMnet; Q5XII8; -.
DR   PhosphoSitePlus; Q5XII8; -.
DR   PaxDb; Q5XII8; -.
DR   PRIDE; Q5XII8; -.
DR   Ensembl; ENSRNOT00000046919; ENSRNOP00000046713; ENSRNOG00000017758.
DR   GeneID; 361985; -.
DR   KEGG; rno:361985; -.
DR   UCSC; RGD:1359625; rat.
DR   RGD; 1359625; LOC361985.
DR   eggNOG; ENOG502QUKH; Eukaryota.
DR   GeneTree; ENSGT00510000047366; -.
DR   InParanoid; Q5XII8; -.
DR   OrthoDB; 1581753at2759; -.
DR   PRO; PR:Q5XII8; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000017758; Expressed in skeletal muscle tissue and 20 other tissues.
DR   ExpressionAtlas; Q5XII8; baseline and differential.
DR   Genevisible; Q5XII8; RN.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR   GO; GO:0006909; P:phagocytosis; ISS:UniProtKB.
DR   InterPro; IPR010876; C1orf43.
DR   PANTHER; PTHR21425; PTHR21425; 2.
DR   Pfam; PF07406; NICE-3; 2.
PE   1: Evidence at protein level;
KW   Golgi apparatus; Membrane; Mitochondrion; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..235
FT                   /note="Protein C1orf43 homolog"
FT                   /id="PRO_0000089259"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   235 AA;  26642 MW;  ECE4DCB29BF169E4 CRC64;
     MASSSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV GHNAPKDLKE
     EIDIRLSRVQ DIKYEPQLLA DDDTRLLQLE TQGSQKIPFH AEGRHPCSLM GKNFRSYLLD
     LRNTSTPFKG VRKALIDTLL DGYETARYGT GVFGQSEYLR YQEALSELAT VVKARIGSSQ
     RQHQSAAKDL TQSPEMSPTT IQVTYLPSSQ KSKRPKHFLE LKSFKDNYNT LESTL
 
 
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