CA043_RAT
ID CA043_RAT Reviewed; 235 AA.
AC Q5XII8;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Protein C1orf43 homolog;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: General regulator of phagocytosis. Required to uptake Gram
CC negative bacterium by macrophages. {ECO:0000250|UniProtKB:Q9BWL3}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q9BWL3}.
CC Mitochondrion {ECO:0000250|UniProtKB:Q9BWL3}.
CC -!- DOMAIN: N-terminal region is required for phagocytosis of Gram negative
CC bacterium. {ECO:0000250|UniProtKB:Q9BWL3}.
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DR EMBL; BC083693; AAH83693.1; -; mRNA.
DR RefSeq; NP_001014196.1; NM_001014174.1.
DR AlphaFoldDB; Q5XII8; -.
DR STRING; 10116.ENSRNOP00000046713; -.
DR iPTMnet; Q5XII8; -.
DR PhosphoSitePlus; Q5XII8; -.
DR PaxDb; Q5XII8; -.
DR PRIDE; Q5XII8; -.
DR Ensembl; ENSRNOT00000046919; ENSRNOP00000046713; ENSRNOG00000017758.
DR GeneID; 361985; -.
DR KEGG; rno:361985; -.
DR UCSC; RGD:1359625; rat.
DR RGD; 1359625; LOC361985.
DR eggNOG; ENOG502QUKH; Eukaryota.
DR GeneTree; ENSGT00510000047366; -.
DR InParanoid; Q5XII8; -.
DR OrthoDB; 1581753at2759; -.
DR PRO; PR:Q5XII8; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000017758; Expressed in skeletal muscle tissue and 20 other tissues.
DR ExpressionAtlas; Q5XII8; baseline and differential.
DR Genevisible; Q5XII8; RN.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR GO; GO:0006909; P:phagocytosis; ISS:UniProtKB.
DR InterPro; IPR010876; C1orf43.
DR PANTHER; PTHR21425; PTHR21425; 2.
DR Pfam; PF07406; NICE-3; 2.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Mitochondrion; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..235
FT /note="Protein C1orf43 homolog"
FT /id="PRO_0000089259"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 235 AA; 26642 MW; ECE4DCB29BF169E4 CRC64;
MASSSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV GHNAPKDLKE
EIDIRLSRVQ DIKYEPQLLA DDDTRLLQLE TQGSQKIPFH AEGRHPCSLM GKNFRSYLLD
LRNTSTPFKG VRKALIDTLL DGYETARYGT GVFGQSEYLR YQEALSELAT VVKARIGSSQ
RQHQSAAKDL TQSPEMSPTT IQVTYLPSSQ KSKRPKHFLE LKSFKDNYNT LESTL