UBX2A_HUMAN
ID UBX2A_HUMAN Reviewed; 259 AA.
AC P68543; A8K577; B7ZKP8; Q569G8;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=UBX domain-containing protein 2A;
DE AltName: Full=UBX domain-containing protein 4;
GN Name=UBXN2A; Synonyms=UBXD4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Adipose tissue;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Liver, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC P68543; Q96IM9: DYDC2; NbExp=3; IntAct=EBI-1993668, EBI-749277;
CC P68543; Q9BZV1: UBXN6; NbExp=3; IntAct=EBI-1993668, EBI-1993899;
CC P68543; P55072: VCP; NbExp=17; IntAct=EBI-1993668, EBI-355164;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P68543-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P68543-2; Sequence=VSP_056306;
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DR EMBL; AK291192; BAF83881.1; -; mRNA.
DR EMBL; AL832079; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC066692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC092484; AAH92484.1; -; mRNA.
DR EMBL; BC093681; AAH93681.1; -; mRNA.
DR EMBL; BC111997; AAI11998.1; -; mRNA.
DR EMBL; BC143298; AAI43299.1; -; mRNA.
DR CCDS; CCDS1704.1; -. [P68543-1]
DR RefSeq; NP_859064.2; NM_181713.3. [P68543-1]
DR RefSeq; XP_005264223.1; XM_005264166.4. [P68543-1]
DR RefSeq; XP_005264224.1; XM_005264167.4. [P68543-1]
DR RefSeq; XP_005264225.1; XM_005264168.4. [P68543-1]
DR RefSeq; XP_005264226.1; XM_005264169.4. [P68543-1]
DR RefSeq; XP_011530935.1; XM_011532633.2. [P68543-1]
DR AlphaFoldDB; P68543; -.
DR SMR; P68543; -.
DR BioGRID; 127913; 27.
DR IntAct; P68543; 17.
DR MINT; P68543; -.
DR STRING; 9606.ENSP00000312107; -.
DR iPTMnet; P68543; -.
DR PhosphoSitePlus; P68543; -.
DR BioMuta; UBXN2A; -.
DR DMDM; 55976658; -.
DR EPD; P68543; -.
DR jPOST; P68543; -.
DR MassIVE; P68543; -.
DR MaxQB; P68543; -.
DR PaxDb; P68543; -.
DR PeptideAtlas; P68543; -.
DR PRIDE; P68543; -.
DR ProteomicsDB; 57542; -. [P68543-1]
DR ProteomicsDB; 7186; -.
DR Antibodypedia; 58573; 100 antibodies from 19 providers.
DR DNASU; 165324; -.
DR Ensembl; ENST00000309033.5; ENSP00000312107.4; ENSG00000173960.14. [P68543-1]
DR Ensembl; ENST00000404924.5; ENSP00000385525.1; ENSG00000173960.14. [P68543-1]
DR GeneID; 165324; -.
DR KEGG; hsa:165324; -.
DR MANE-Select; ENST00000309033.5; ENSP00000312107.4; NM_181713.4; NP_859064.2.
DR UCSC; uc002ren.4; human. [P68543-1]
DR CTD; 165324; -.
DR DisGeNET; 165324; -.
DR GeneCards; UBXN2A; -.
DR HGNC; HGNC:27265; UBXN2A.
DR HPA; ENSG00000173960; Low tissue specificity.
DR neXtProt; NX_P68543; -.
DR OpenTargets; ENSG00000173960; -.
DR PharmGKB; PA162408375; -.
DR VEuPathDB; HostDB:ENSG00000173960; -.
DR eggNOG; KOG2086; Eukaryota.
DR GeneTree; ENSGT00520000055567; -.
DR HOGENOM; CLU_029402_3_1_1; -.
DR InParanoid; P68543; -.
DR OMA; NGTEQNC; -.
DR OrthoDB; 1175850at2759; -.
DR PhylomeDB; P68543; -.
DR TreeFam; TF312973; -.
DR PathwayCommons; P68543; -.
DR SignaLink; P68543; -.
DR BioGRID-ORCS; 165324; 11 hits in 1074 CRISPR screens.
DR ChiTaRS; UBXN2A; human.
DR GenomeRNAi; 165324; -.
DR Pharos; P68543; Tbio.
DR PRO; PR:P68543; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P68543; protein.
DR Bgee; ENSG00000173960; Expressed in buccal mucosa cell and 195 other tissues.
DR Genevisible; P68543; HS.
DR GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0033130; F:acetylcholine receptor binding; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0061025; P:membrane fusion; IBA:GO_Central.
DR GO; GO:0031468; P:nuclear membrane reassembly; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:0031396; P:regulation of protein ubiquitination; IEA:Ensembl.
DR Gene3D; 3.30.420.210; -; 1.
DR InterPro; IPR036241; NSFL1C_SEP_dom_sf.
DR InterPro; IPR012989; SEP_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001012; UBX_dom.
DR Pfam; PF08059; SEP; 1.
DR Pfam; PF00789; UBX; 1.
DR SMART; SM00553; SEP; 1.
DR SMART; SM00166; UBX; 1.
DR SUPFAM; SSF102848; SSF102848; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS51399; SEP; 1.
DR PROSITE; PS50033; UBX; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..259
FT /note="UBX domain-containing protein 2A"
FT /id="PRO_0000211031"
FT DOMAIN 60..124
FT /note="SEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00732"
FT DOMAIN 169..246
FT /note="UBX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT VAR_SEQ 142..194
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_056306"
SQ SEQUENCE 259 AA; 29278 MW; 4B2CD68375A0BABD CRC64;
MKDVDNLKSI KEEWVCETGS DNQPLGNNQQ SNCEYFVDSL FEEAQKVSSK CVSPAEQKKQ
VDVNIKLWKN GFTVNDDFRS YSDGASQQFL NSIKKGELPS ELQGIFDKEE VDVKVEDKKN
EICLSTKPVF QPFSGQGHRL GSATPKIVSK AKNIEVENKN NLSAVPLNNL EPITNIQIWL
ANGKRIVQKF NITHRVSHIK DFIEKYQGSQ RSPPFSLATA LPVLRLLDET LTLEEADLQN
AVIIQRLQKT ASFRELSEH
