UBX2A_MOUSE
ID UBX2A_MOUSE Reviewed; 258 AA.
AC Q99KJ0;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=UBX domain-containing protein 2A;
DE AltName: Full=UBX domain-containing protein 4;
GN Name=Ubxn2a; Synonyms=Ubxd4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK031821; BAC27566.1; -; mRNA.
DR EMBL; AK041556; BAC30984.1; -; mRNA.
DR EMBL; BC004632; AAH04632.1; -; mRNA.
DR CCDS; CCDS25795.1; -.
DR RefSeq; NP_663416.1; NM_145441.3.
DR AlphaFoldDB; Q99KJ0; -.
DR SMR; Q99KJ0; -.
DR BioGRID; 229908; 6.
DR STRING; 10090.ENSMUSP00000020962; -.
DR iPTMnet; Q99KJ0; -.
DR PhosphoSitePlus; Q99KJ0; -.
DR EPD; Q99KJ0; -.
DR MaxQB; Q99KJ0; -.
DR PaxDb; Q99KJ0; -.
DR PeptideAtlas; Q99KJ0; -.
DR PRIDE; Q99KJ0; -.
DR ProteomicsDB; 298425; -.
DR Antibodypedia; 58573; 100 antibodies from 19 providers.
DR DNASU; 217379; -.
DR Ensembl; ENSMUST00000020962; ENSMUSP00000020962; ENSMUSG00000020634.
DR Ensembl; ENSMUST00000142867; ENSMUSP00000118834; ENSMUSG00000020634.
DR GeneID; 217379; -.
DR KEGG; mmu:217379; -.
DR UCSC; uc007myr.1; mouse.
DR CTD; 165324; -.
DR MGI; MGI:2442310; Ubxn2a.
DR VEuPathDB; HostDB:ENSMUSG00000020634; -.
DR eggNOG; KOG2086; Eukaryota.
DR GeneTree; ENSGT00520000055567; -.
DR HOGENOM; CLU_029402_3_1_1; -.
DR InParanoid; Q99KJ0; -.
DR OMA; NGTEQNC; -.
DR OrthoDB; 1175850at2759; -.
DR PhylomeDB; Q99KJ0; -.
DR TreeFam; TF312973; -.
DR BioGRID-ORCS; 217379; 11 hits in 71 CRISPR screens.
DR ChiTaRS; Ubxn2a; mouse.
DR PRO; PR:Q99KJ0; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q99KJ0; protein.
DR Bgee; ENSMUSG00000020634; Expressed in pontine nuclear group and 228 other tissues.
DR ExpressionAtlas; Q99KJ0; baseline and differential.
DR Genevisible; Q99KJ0; MM.
DR GO; GO:0005801; C:cis-Golgi network; IDA:MGI.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0033130; F:acetylcholine receptor binding; IPI:MGI.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEP:MGI.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0061025; P:membrane fusion; IBA:GO_Central.
DR GO; GO:0031468; P:nuclear membrane reassembly; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; ISO:MGI.
DR GO; GO:0042176; P:regulation of protein catabolic process; IDA:MGI.
DR GO; GO:0031396; P:regulation of protein ubiquitination; IDA:MGI.
DR Gene3D; 3.30.420.210; -; 1.
DR InterPro; IPR036241; NSFL1C_SEP_dom_sf.
DR InterPro; IPR012989; SEP_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001012; UBX_dom.
DR Pfam; PF08059; SEP; 1.
DR Pfam; PF00789; UBX; 1.
DR SMART; SM00553; SEP; 1.
DR SMART; SM00166; UBX; 1.
DR SUPFAM; SSF102848; SSF102848; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS51399; SEP; 1.
DR PROSITE; PS50033; UBX; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..258
FT /note="UBX domain-containing protein 2A"
FT /id="PRO_0000211032"
FT DOMAIN 61..125
FT /note="SEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00732"
FT DOMAIN 170..247
FT /note="UBX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 258 AA; 29197 MW; 2901BAE396F5CE2A CRC64;
MKEVDNLDSI KEEWACETGP PDSQPLNDNQ QKDCEYFVDS LFEEAGKAGA KCLSPTEQKK
QVDVNIKLWK NGFTVNDDFR SYSDGASQQF LNSIKKGELP SELWGIFDKE EVDVKVEDKK
NEVCMSTKPV FQPFSGQGHR LGSATPRIVS KAKSVEVDNK STLSAVSLNN LEPITRIQIW
LANGERTVQR FNVSHRVSHI KDFIEKYQGS QRSPPFALAT ALPFLRFLDE TLTLEEADLK
NAVIIQRLQK TAEPFRKL
