ID   UBX2B_XENLA             Reviewed;         350 AA.
AC   Q0P3R5; Q5PPW1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=UBX domain-containing protein 2B;
DE   AltName: Full=NSFL1 cofactor p37;
DE   AltName: Full=p97 cofactor p37;
GN   Name=ubxn2b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Fat body, and Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein required for Golgi and endoplasmic reticulum
CC       biogenesis. Involved in Golgi and endoplasmic reticulum maintenance
CC       during interphase and in their reassembly at the end of mitosis.
CC       Regulates the centrosomal levels of kinase aurka-a/Aurora A during
CC       mitotic progression by promoting aurka-a removal from centrosomes in
CC       prophase. Also, regulates spindle orientation during mitosis.
CC       {ECO:0000250|UniProtKB:Q14CS0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0C627}.
CC       Cytoplasm, cytosol {ECO:0000250|UniProtKB:P0C627}. Endoplasmic
CC       reticulum {ECO:0000250|UniProtKB:P0C627}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:P0C627}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250|UniProtKB:Q0KL01}.
CC       Note=Localizes to centrosome during mitotic prophase and metaphase.
CC       {ECO:0000250|UniProtKB:Q0KL01}.
CC   -!- SIMILARITY: Belongs to the NSFL1C family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC087473; AAH87473.1; -; mRNA.
DR   EMBL; BC122501; AAI22502.1; -; mRNA.
DR   RefSeq; NP_001088797.1; NM_001095328.1.
DR   AlphaFoldDB; Q0P3R5; -.
DR   SMR; Q0P3R5; -.
DR   DNASU; 496062; -.
DR   GeneID; 496062; -.
DR   KEGG; xla:496062; -.
DR   CTD; 496062; -.
DR   Xenbase; XB-GENE-6252818; ubxn2b.L.
DR   OMA; IQSRPEF; -.
DR   OrthoDB; 1175850at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 496062; Expressed in brain and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.30.420.210; -; 1.
DR   InterPro; IPR036241; NSFL1C_SEP_dom_sf.
DR   InterPro; IPR012989; SEP_domain.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR001012; UBX_dom.
DR   Pfam; PF08059; SEP; 1.
DR   Pfam; PF00789; UBX; 1.
DR   SMART; SM00553; SEP; 1.
DR   SMART; SM00166; UBX; 1.
DR   SUPFAM; SSF102848; SSF102848; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS51399; SEP; 1.
DR   PROSITE; PS50033; UBX; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Endoplasmic reticulum; Golgi apparatus; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..350
FT                   /note="UBX domain-containing protein 2B"
FT                   /id="PRO_0000315232"
FT   DOMAIN          160..225
FT                   /note="SEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00732"
FT   DOMAIN          271..348
FT                   /note="UBX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   350 AA;  39549 MW;  2105620AE6178422 CRC64;
     MEERENSEEG DDGAGEEEEE DQGSGEDGGE VGAEREQEAE LKDSLRPSVL DLQLALARLC
     EDEYQDQPSK MPVLGLQIKD HQFERSFSGN GKVPSPGKIV NELFKEAKEH GAIPIDDTSK
     SSGAFYRART FTGRGYKLGD SSKREFEYMQ GEDPFEQGQE IQILLKLWSN GFSLDDGELR
     SYSDPINAEF LESVKKGEIP VELQRLVHGG QVNLDMEDHQ DQEYIKPRLK FKAFSGEGKK
     LGSVTPEIIS TPSSPEEEHK RFLNAEVDLD EHVPTTKIQI RLADGTRLIQ RFNLSHRIMD
     VRQFIIHARS DFAQCDFALL TTFPNVELTD ETQTLEEADI LNTVILQRLK