ID   UBX4_YEAST              Reviewed;         416 AA.
AC   P54730; D6VZP1;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=UBX domain-containing protein 4;
GN   Name=UBX4; OrderedLocusNames=YMR067C; ORFNames=YM9916.06C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA   Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA   Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL   Nature 387:90-93(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   INTERACTION WITH CDC48.
RX   PubMed=15258615; DOI=10.1038/sj.embor.7400203;
RA   Schuberth C., Richly H., Rumpf S., Buchberger A.;
RT   "Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent
RT   protein degradation.";
RL   EMBO Rep. 5:818-824(2004).
CC   -!- FUNCTION: Involved in CDC48-dependent protein degradation through the
CC       ubiquitin/proteasome pathway. {ECO:0000250}.
CC   -!- INTERACTION:
CC       P54730; P25694: CDC48; NbExp=5; IntAct=EBI-28127, EBI-4308;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095}. Cytoplasm
CC       {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 3570 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; Z48952; CAA88792.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA09965.1; -; Genomic_DNA.
DR   PIR; S52827; S52827.
DR   RefSeq; NP_013783.1; NM_001182565.1.
DR   AlphaFoldDB; P54730; -.
DR   SMR; P54730; -.
DR   BioGRID; 35242; 232.
DR   DIP; DIP-5070N; -.
DR   IntAct; P54730; 2.
DR   MINT; P54730; -.
DR   STRING; 4932.YMR067C; -.
DR   iPTMnet; P54730; -.
DR   MaxQB; P54730; -.
DR   PaxDb; P54730; -.
DR   PRIDE; P54730; -.
DR   EnsemblFungi; YMR067C_mRNA; YMR067C; YMR067C.
DR   GeneID; 855089; -.
DR   KEGG; sce:YMR067C; -.
DR   SGD; S000004671; UBX4.
DR   VEuPathDB; FungiDB:YMR067C; -.
DR   eggNOG; KOG2699; Eukaryota.
DR   HOGENOM; CLU_667421_0_0_1; -.
DR   InParanoid; P54730; -.
DR   OMA; FPDRTHI; -.
DR   BioCyc; YEAST:G3O-32769-MON; -.
DR   PRO; PR:P54730; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   RNAct; P54730; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0019898; C:extrinsic component of membrane; IDA:SGD.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0012506; C:vesicle membrane; IBA:GO_Central.
DR   GO; GO:0044877; F:protein-containing complex binding; IDA:SGD.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:SGD.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IMP:SGD.
DR   InterPro; IPR021569; TUG-UBL1.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR001012; UBX_dom.
DR   Pfam; PF11470; TUG-UBL1; 1.
DR   Pfam; PF00789; UBX; 1.
DR   SMART; SM00166; UBX; 1.
DR   SUPFAM; SSF54236; SSF54236; 2.
DR   PROSITE; PS50033; UBX; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..416
FT                   /note="UBX domain-containing protein 4"
FT                   /id="PRO_0000211001"
FT   DOMAIN          273..350
FT                   /note="UBX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT   REGION          376..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   416 AA;  46965 MW;  615E5F8EC1DCDD31 CRC64;
     MPMVTVKYNF QLFKCKVSLN STLNDVLHQS IQFFQLHTSS NDWSLIHLDK PVPLDLPWRL
     LNLPTGVNLE LSKSSNFPVA NKTNREDIPF NTIKIRFQIP GRDSVVKEMP SDQPIAPILR
     QMSGAAGDDF KIQVFSKIIE FKTIKDENLT LENLGIQEPS SVRLIFNNTS HSEGISANSA
     IHPKQTPPTM TNPETVASLP PHELHKPSVF LPSDEPLAVI KDQIEDEEDY ELTVEQAKKY
     QKMLSSKAGT LGGPILTKRL REQSANNLPK KNKAISECLL RVKFPDRSHI QIAFKPNEDM
     RTVYNVVSQF LIDENMPFTL NQSHPFKPLA KDDKKLLDDL EFGSKTMLLF ETNSNSNGPL
     IKAHLLEDAQ KITHETRTTP SVNTINKSNP QGPSDNATSI KKTLNRVPKW MKLSKK