ID   UBX6_YEAST              Reviewed;         396 AA.
AC   P47049; D6VWD5;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=UBX domain-containing protein 6;
GN   Name=UBX6; OrderedLocusNames=YJL048C; ORFNames=J1164;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA   Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA   Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA   Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA   Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA   Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA   Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA   Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA   To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA   von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   INTERACTION WITH CDC48.
RX   PubMed=15258615; DOI=10.1038/sj.embor.7400203;
RA   Schuberth C., Richly H., Rumpf S., Buchberger A.;
RT   "Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent
RT   protein degradation.";
RL   EMBO Rep. 5:818-824(2004).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-369, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19779198; DOI=10.1126/science.1172867;
RA   Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT   "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT   into evolution.";
RL   Science 325:1682-1686(2009).
CC   -!- FUNCTION: Involved in CDC48-dependent protein degradation through the
CC       ubiquitin/proteasome pathway. {ECO:0000250}.
CC   -!- INTERACTION:
CC       P47049; P25694: CDC48; NbExp=3; IntAct=EBI-25866, EBI-4308;
CC   -!- MISCELLANEOUS: Present with 1340 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; Z49323; CAA89339.1; -; Genomic_DNA.
DR   EMBL; AY692689; AAT92708.1; -; Genomic_DNA.
DR   EMBL; BK006943; DAA08751.1; -; Genomic_DNA.
DR   PIR; S56820; S56820.
DR   RefSeq; NP_012487.1; NM_001181481.1.
DR   AlphaFoldDB; P47049; -.
DR   SMR; P47049; -.
DR   BioGRID; 33707; 41.
DR   DIP; DIP-1906N; -.
DR   IntAct; P47049; 8.
DR   MINT; P47049; -.
DR   STRING; 4932.YJL048C; -.
DR   iPTMnet; P47049; -.
DR   PaxDb; P47049; -.
DR   PRIDE; P47049; -.
DR   EnsemblFungi; YJL048C_mRNA; YJL048C; YJL048C.
DR   GeneID; 853399; -.
DR   KEGG; sce:YJL048C; -.
DR   SGD; S000003584; UBX6.
DR   VEuPathDB; FungiDB:YJL048C; -.
DR   eggNOG; KOG2689; Eukaryota.
DR   GeneTree; ENSGT00940000176709; -.
DR   HOGENOM; CLU_034966_0_0_1; -.
DR   InParanoid; P47049; -.
DR   OMA; GWISAVI; -.
DR   BioCyc; YEAST:G3O-31512-MON; -.
DR   PRO; PR:P47049; -.
DR   Proteomes; UP000002311; Chromosome X.
DR   RNAct; P47049; protein.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:SGD.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IMP:SGD.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR001012; UBX_dom.
DR   Pfam; PF00789; UBX; 1.
DR   SMART; SM00166; UBX; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50033; UBX; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..396
FT                   /note="UBX domain-containing protein 6"
FT                   /id="PRO_0000211003"
FT   DOMAIN          186..264
FT                   /note="UBX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT   REGION          333..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          374..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..361
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         369
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19779198"
SQ   SEQUENCE   396 AA;  45016 MW;  42C6217D2B52E425 CRC64;
     MYEMSGIDSL FHDRVVHDYS HTSEQVIVVY ISSAAGDNSW LHQWFKPGNL SDEERENILW
     VRLVNGTKEC LLFKSIFPSS SAPSINILQN GLLECSIQGN SLSREQDPWE TFINGLQSVF
     KGQVTKRKLF SKSNEEYQRV KRMIQNDKLE RKYVFQNTND PQRKPQKWKQ LTVTDNVSYK
     SQKGFLAQNY CTLQLKLPNG YTISNTFPPQ TKLHKVRMWL DYNCYDDGTP YLFHRNIPRV
     TLTRNDELKS LQELDLLPRS TLILEPLEAN NKTFDYMEQS SLLHKVYSGL TSFWAKEPEV
     DASSSRLGYQ RLGTNVSNSA NYSLQKLSSL DMVSDGGGGG GGDSMTPSAY TTPRMYPSNG
     TSQLRQNVSE LNLSSNNSAS NTKVRTLGYS NNNGNN