ID   UBXN4_PONAB             Reviewed;         508 AA.
AC   Q5R4I3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=UBX domain-containing protein 4;
DE   AltName: Full=UBX domain-containing protein 2;
GN   Name=UBXN4; Synonyms=UBXD2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in endoplasmic reticulum-associated protein
CC       degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP
CC       to the ER during ERAD. {ECO:0000250|UniProtKB:Q92575}.
CC   -!- SUBUNIT: Directly interacts with VCP. Interacts with UBQLN1. Forms a
CC       complex with VCP and UBQLN1. {ECO:0000250|UniProtKB:Q92575}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q92575}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q92575}. Nucleus envelope
CC       {ECO:0000250|UniProtKB:Q92575}. Note=Both the N- and the C-terminus
CC       face the cytosol. Also found in the nucleus envelope contiguous to the
CC       ER. {ECO:0000250|UniProtKB:Q92575}.
CC   -!- DOMAIN: The UBX domain is required for interaction with VCP.
CC       {ECO:0000250|UniProtKB:Q92575}.
CC   -!- DOMAIN: The intramembrane domain also contains the signal for ER
CC       targeting. {ECO:0000250|UniProtKB:Q92575}.
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DR   EMBL; CR861265; CAH93333.1; -; mRNA.
DR   RefSeq; NP_001126962.1; NM_001133490.1.
DR   AlphaFoldDB; Q5R4I3; -.
DR   SMR; Q5R4I3; -.
DR   Ensembl; ENSPPYT00000014887; ENSPPYP00000014304; ENSPPYG00000012819.
DR   GeneID; 100173981; -.
DR   KEGG; pon:100173981; -.
DR   CTD; 23190; -.
DR   eggNOG; KOG2507; Eukaryota.
DR   GeneTree; ENSGT00940000160205; -.
DR   InParanoid; Q5R4I3; -.
DR   OrthoDB; 1334491at2759; -.
DR   Proteomes; UP000001595; Chromosome 2B.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; ISS:UniProtKB.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR001012; UBX_dom.
DR   Pfam; PF00789; UBX; 1.
DR   SMART; SM00166; UBX; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50033; UBX; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Nucleus; Phosphoprotein;
KW   Reference proteome; Unfolded protein response.
FT   CHAIN           1..508
FT                   /note="UBX domain-containing protein 4"
FT                   /id="PRO_0000317475"
FT   TOPO_DOM        1..413
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        414..434
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        435..508
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          315..393
FT                   /note="UBX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT   REGION          1..200
FT                   /note="Interaction with UBQLN1"
FT                   /evidence="ECO:0000250|UniProtKB:Q92575"
FT   REGION          117..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          440..508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        440..459
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..495
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         489
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q92575"
SQ   SEQUENCE   508 AA;  56763 MW;  7C20BCFF146C9217 CRC64;
     MLWFQGAIPA AIATAKRSGA VFVVFVAGDD EQSTQMAASW EDDKVTEASS NSFVAIKIDT
     KSEACLQFSQ IYPVVCVPSS FFIGDSGIPL EVIAGSVSAD ELVTRIHKVR QMHLLKSETS
     VANGSQSESS VSTPSASFEP NNTCENSQSR NAELCEIPPT SDTKSDTATG GESAGHATSS
     QEPSGCSDQR PAEDLNIRVE RLTKKLEERR EEKRKEEEQR EIKKEIERRK TGKEMLDYKR
     KQEEELTKRM LEERNREKAE DRAARERIKQ QIALDRAERA ARFAKTKEEV EAAKAAALLA
     KQAEMEVKRE SYARERSTVA RIQFRLPDGS SFTNQFPSDA PLEEARQFAA QTVGNTYGNF
     SLATMFPRRE FTKEDYKKKL LDLELAPSAS VVVLPAGRPT ASIVHSSSGD IWTLLGTVLY
     PFLAIWRLIS NFLFSNPPPT QTSVRVTSSE PPNPASSSKS EKREPVRKRV LEKRGDDFKK
     EGKIYRLRTQ DDGEDENNTW NGNSTQQM