ID   UBXN5_CAEEL             Reviewed;         174 AA.
AC   Q7YWU9;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=UBX domain-containing protein 5 {ECO:0000305};
GN   Name=ubxn-5 {ECO:0000312|WormBase:T01E8.9};
GN   ORFNames=T01E8.9 {ECO:0000312|WormBase:T01E8.9};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=17498661; DOI=10.1016/j.bbrc.2007.04.163;
RA   Yamauchi S., Sasagawa Y., Ogura T., Yamanaka K.;
RT   "Differential expression pattern of UBX family genes in Caenorhabditis
RT   elegans.";
RL   Biochem. Biophys. Res. Commun. 358:545-552(2007).
RN   [3] {ECO:0000305}
RP   FUNCTION, IDENTIFICATION IN A COMPLEX WITH CDC-48.1 AND ATX-3, AND
RP   INTERACTION WITH ATX-3; CDC-48.1 AND CDC-48.2.
RX   PubMed=19545544; DOI=10.1016/j.bbrc.2009.06.092;
RA   Rodrigues A.J., Neves-Carvalho A., Ferro A., Rokka A., Corthals G.,
RA   Logarinho E., Maciel P.;
RT   "ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis
RT   elegans.";
RL   Biochem. Biophys. Res. Commun. 386:575-581(2009).
CC   -!- FUNCTION: Probably acts as an adapter for ATPase cdc-48.1 and/or cdc-
CC       48.2, conferring substrate specificity. Unlike other UBX domain-
CC       containing protein does not bind 'Lys-48'-polyubiquitinated chain.
CC       {ECO:0000269|PubMed:19545544}.
CC   -!- SUBUNIT: Forms a complex composed of deubiquitinating enzyme atx-3,
CC       adapter ubxn-5 and cdc-48.1. Interacts with atx-3 (via C-terminus).
CC       Interacts with cdc-48.1 (via N-terminus) and cdc-48.2.
CC       {ECO:0000269|PubMed:19545544}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in the germline.
CC       {ECO:0000269|PubMed:17498661}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at L4 larval stage and to a lesser
CC       extent in adults. {ECO:0000269|PubMed:17498661}.
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DR   EMBL; BX284602; CAE17928.1; -; Genomic_DNA.
DR   RefSeq; NP_001022300.1; NM_001027129.3.
DR   AlphaFoldDB; Q7YWU9; -.
DR   SMR; Q7YWU9; -.
DR   STRING; 6239.T01E8.9; -.
DR   PaxDb; Q7YWU9; -.
DR   EnsemblMetazoa; T01E8.9.1; T01E8.9.1; WBGene00011336.
DR   GeneID; 3565635; -.
DR   KEGG; cel:CELE_T01E8.9; -.
DR   UCSC; T01E8.9; c. elegans.
DR   CTD; 3565635; -.
DR   WormBase; T01E8.9; CE34978; WBGene00011336; ubxn-5.
DR   eggNOG; ENOG502TIX5; Eukaryota.
DR   HOGENOM; CLU_1541505_0_0_1; -.
DR   InParanoid; Q7YWU9; -.
DR   OMA; PRAEIHC; -.
DR   OrthoDB; 17287at6231; -.
DR   PRO; PR:Q7YWU9; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00011336; Expressed in larva and 2 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR001012; UBX_dom.
DR   Pfam; PF00789; UBX; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50033; UBX; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..174
FT                   /note="UBX domain-containing protein 5"
FT                   /id="PRO_0000444376"
FT   DOMAIN          74..120
FT                   /note="UBX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT   COILED          8..58
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   174 AA;  20128 MW;  1D7A60748065967D CRC64;
     MPTNNHVQKE KFAEDRALLS QQNKEYAESL AKDIAKKEEK DKIRFEAEQK ELRKKTIQDY
     REKLKGTVSQ GPLRLLVRYP NGSRLILSFS PSQPMTSLFD AIILNPACPD YFSVRSVYPR
     AEIHCYPAWY HTIFNAEFKD ETEKGANNVA KETNEVKCLE TIPNNSILYV NLIQ