UBXN6_BOVIN
ID UBXN6_BOVIN Reviewed; 441 AA.
AC Q2KIJ6;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=UBX domain-containing protein 6 {ECO:0000305};
DE AltName: Full=UBX domain-containing protein 1 {ECO:0000250|UniProtKB:Q9BZV1};
GN Name=UBXN6 {ECO:0000250|UniProtKB:Q9BZV1};
GN Synonyms=UBXD1 {ECO:0000250|UniProtKB:Q9BZV1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May negatively regulate the ATPase activity of VCP, an ATP-
CC driven segregase that associates with different cofactors to control a
CC wide variety of cellular processes. As a cofactor of VCP, it may play a
CC role in the transport of CAV1 to lysosomes for degradation. It may also
CC play a role in endoplasmic reticulum-associated degradation (ERAD) of
CC misfolded proteins. Together with VCP and other cofactors, it may play
CC a role in macroautophagy, regulating for instance the clearance of
CC damaged lysosomes. {ECO:0000250|UniProtKB:Q9BZV1}.
CC -!- SUBUNIT: Interacts with VCP through the PUB domain (via C-terminus) and
CC VIM motif (via N-terminus); the interaction is direct. Forms a ternary
CC complex with CAV1 and VCP. Interacts with SYVN1. Interacts with
CC HERPUD1. Interacts with VCPKMT. May interact with DERL1. Interacts with
CC PLAA, VCP and YOD1; may form a complex involved in macroautophagy.
CC Interacts with LMAN1. {ECO:0000250|UniProtKB:Q9BZV1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BZV1}.
CC Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BZV1}. Membrane
CC {ECO:0000250|UniProtKB:Q9BZV1}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9BZV1}. Nucleus {ECO:0000250|UniProtKB:Q9BZV1}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000250|UniProtKB:Q9BZV1}. Early endosome membrane
CC {ECO:0000250|UniProtKB:Q9BZV1}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9BZV1}. Late endosome membrane
CC {ECO:0000250|UniProtKB:Q9BZV1}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9BZV1}. Lysosome membrane
CC {ECO:0000250|UniProtKB:Q9BZV1}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9BZV1}. Note=Localizes at the centrosome both
CC in interphase and during mitosis. May be recruited to endosomal and
CC lysosomal membranes as part of a ternary complex with CAV1 and VCP.
CC Recruited to damaged lysosomes decorated with K48-linked ubiquitin
CC chains. {ECO:0000250|UniProtKB:Q9BZV1}.
CC -!- DOMAIN: The UBX domain lacks key residues critical for VCP binding.
CC {ECO:0000250|UniProtKB:Q9BZV1}.
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DR EMBL; BC112614; AAI12615.1; -; mRNA.
DR RefSeq; NP_001039451.1; NM_001045986.1.
DR AlphaFoldDB; Q2KIJ6; -.
DR SMR; Q2KIJ6; -.
DR STRING; 9913.ENSBTAP00000010767; -.
DR PaxDb; Q2KIJ6; -.
DR PRIDE; Q2KIJ6; -.
DR GeneID; 507936; -.
DR KEGG; bta:507936; -.
DR CTD; 80700; -.
DR eggNOG; KOG2699; Eukaryota.
DR InParanoid; Q2KIJ6; -.
DR OrthoDB; 1288120at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR GO; GO:0019898; C:extrinsic component of membrane; ISS:UniProtKB.
DR GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032510; P:endosome to lysosome transport via multivesicular body sorting pathway; ISS:UniProtKB.
DR GO; GO:0036503; P:ERAD pathway; ISS:UniProtKB.
DR GO; GO:0016236; P:macroautophagy; ISS:UniProtKB.
DR CDD; cd10460; PUB_UBXD1; 1.
DR InterPro; IPR036339; PUB-like_dom_sf.
DR InterPro; IPR018997; PUB_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001012; UBX_dom.
DR InterPro; IPR042774; UBXN6_PUB.
DR Pfam; PF09409; PUB; 1.
DR Pfam; PF00789; UBX; 1.
DR SMART; SM00166; UBX; 1.
DR SUPFAM; SSF143503; SSF143503; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50033; UBX; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Endosome; Lysosome; Membrane; Nucleus;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..441
FT /note="UBX domain-containing protein 6"
FT /id="PRO_0000240351"
FT DOMAIN 175..244
FT /note="PUB"
FT /evidence="ECO:0000255"
FT DOMAIN 332..408
FT /note="UBX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT REGION 1..10
FT /note="Mediates interaction with LMAN1"
FT /evidence="ECO:0000250|UniProtKB:Q9BZV1"
FT REGION 12..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..63
FT /note="VCP/p97-interacting motif (VIM)"
FT /evidence="ECO:0000250|UniProtKB:Q9BZV1"
FT REGION 62..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 49733 MW; 20C1563B88FF0A3E CRC64;
MKKFFQEIKA DIKFKSAGPG QKLTESVGEK APKEKPSQPP VRQPRQGPTN EAQMAAAAAL
ARLEQKQPRA RGPTSQDSIR NQVRKELRAE AAVSGDPEAP GSNTAPEPKE EGSAHLAVPG
VYFTCPLTGA ILRKDQRDAR IREAILMHFS TDPVAASIMK IHTFNKDRDR VKLGVDTIAK
YLDNIHLHPE EEKYRKIKVQ NKVFQERIHC LEGTHEFFEA IGFQKVLLPI PDQEGPEEFY
VLSEAALAQP QSLEWHKEQL LSAEPVRATL ARQRRVFRPS TLASQFDLPA DFFNLTAEEI
KREQRLRSEA VERLSVLRTK AMREREEQRE MRKYTYTLLR VRLPDGCLLQ GTFYARERVA
ALYGFVREAL QNDWLPFELL ASGGQKLSED ENLAFNECGL VPSALLTFSL DAAVLEDIRA
AGTQPDTSIL KPELLSAIEK L
