UBXN6_CAEEL
ID UBXN6_CAEEL Reviewed; 437 AA.
AC Q8WTJ4;
DT 23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=UBX domain-containing protein 6 {ECO:0000305};
GN Name=ubxn-6 {ECO:0000312|WormBase:H06H21.6};
GN ORFNames=H06H21.6 {ECO:0000312|WormBase:H06H21.6};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=17498661; DOI=10.1016/j.bbrc.2007.04.163;
RA Yamauchi S., Sasagawa Y., Ogura T., Yamanaka K.;
RT "Differential expression pattern of UBX family genes in Caenorhabditis
RT elegans.";
RL Biochem. Biophys. Res. Commun. 358:545-552(2007).
RN [3] {ECO:0000305}
RP FUNCTION, AND INTERACTION WITH CDC-48.1 AND CDC-48.2.
RX PubMed=20977550; DOI=10.1111/j.1365-2443.2010.01454.x;
RA Sasagawa Y., Yamanaka K., Saito-Sasagawa Y., Ogura T.;
RT "Caenorhabditis elegans UBX cofactors for CDC-48/p97 control
RT spermatogenesis.";
RL Genes Cells 15:1201-1215(2010).
RN [4]
RP FUNCTION, INDUCTION BY STARVATION, AND DISRUPTION PHENOTYPE.
RX PubMed=30595383; DOI=10.1016/j.bbrc.2018.12.155;
RA Mojumder S., Sawamura R., Murayama Y., Ogura T., Yamanaka K.;
RT "Functional characterization of UBXN-6, a C-terminal cofactor of CDC-48, in
RT C. elegans.";
RL Biochem. Biophys. Res. Commun. 509:462-468(2019).
CC -!- FUNCTION: Probably acts as an adapter for ATPase cdc-48.1 and/or cdc-
CC 48.2, conferring substrate specificity. Involved in the lysosomal
CC clearance of cellular material in diet restricted conditions
CC (PubMed:30595383). {ECO:0000269|PubMed:30595383,
CC ECO:0000305|PubMed:20977550}.
CC -!- SUBUNIT: Interacts with cdc-48.1 (via N-terminus) and cdc-48.2 (via N-
CC terminus). {ECO:0000269|PubMed:20977550}.
CC -!- TISSUE SPECIFICITY: Expressed in the pharynx and some head neurons.
CC {ECO:0000269|PubMed:17498661}.
CC -!- DEVELOPMENTAL STAGE: Expressed at L4 larval stage and in adults.
CC Expressed at low levels in embryos and between the L1 and L3 larval
CC stages. {ECO:0000269|PubMed:17498661}.
CC -!- INDUCTION: Up-regulated in response to starvation (at protein level).
CC {ECO:0000269|PubMed:30595383}.
CC -!- DISRUPTION PHENOTYPE: Reduced lifespan (PubMed:30595383). Prolonged
CC expression of the lysosomal protein glo-1 12 hours after starvation
CC (PubMed:30595383). {ECO:0000269|PubMed:30595383}.
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DR EMBL; BX284604; CCD72219.1; -; Genomic_DNA.
DR RefSeq; NP_500648.2; NM_068247.5.
DR AlphaFoldDB; Q8WTJ4; -.
DR SMR; Q8WTJ4; -.
DR STRING; 6239.H06H21.6.1; -.
DR EPD; Q8WTJ4; -.
DR PaxDb; Q8WTJ4; -.
DR PeptideAtlas; Q8WTJ4; -.
DR EnsemblMetazoa; H06H21.6.1; H06H21.6.1; WBGene00019163.
DR GeneID; 177253; -.
DR KEGG; cel:CELE_H06H21.6; -.
DR UCSC; H06H21.6.1; c. elegans.
DR CTD; 177253; -.
DR WormBase; H06H21.6; CE33662; WBGene00019163; ubxn-6.
DR eggNOG; KOG2699; Eukaryota.
DR GeneTree; ENSGT00940000157273; -.
DR HOGENOM; CLU_033280_2_0_1; -.
DR InParanoid; Q8WTJ4; -.
DR OMA; RMQKNEP; -.
DR OrthoDB; 1288120at2759; -.
DR PhylomeDB; Q8WTJ4; -.
DR PRO; PR:Q8WTJ4; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00019163; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR CDD; cd10460; PUB_UBXD1; 1.
DR InterPro; IPR036339; PUB-like_dom_sf.
DR InterPro; IPR018997; PUB_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001012; UBX_dom.
DR InterPro; IPR042774; UBXN6_PUB.
DR Pfam; PF09409; PUB; 1.
DR SUPFAM; SSF143503; SSF143503; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50033; UBX; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..437
FT /note="UBX domain-containing protein 6"
FT /id="PRO_0000444377"
FT DOMAIN 179..251
FT /note="PUB"
FT /evidence="ECO:0000255"
FT DOMAIN 332..409
FT /note="UBX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 437 AA; 49000 MW; EE888F8FAC3759F7 CRC64;
MNSFKKFLNK KRVQNHFKKS GEGVRLSSGE SSSQPSAHAG AAQGGQIDRV AAADIAAQAA
FKRMQKNEPQ QNAGKRRIQM IAKRELEEER RQVEDLNISG TSSLQQPDRE QHLEHSSAIS
RVLYTSELLG EHHIRSKADL LEDIKNFLSD QISEADDEND KVIAAVLMLY SLNKKHPKET
AIETICKYCQ NILEHPGEDK YKSIRLGNKA FQERVASVVG GRAFLEAVGF TEKSEGEDKF
LVFTKPSDVH LVEALEALKD GQAVPIKVAR NLEIFKLKEG QKPKAPKLAD DFYNLSTAEL
KAEQRNKEMQ VERMLTLRTK EMRQKDEQMT NYRYKYTLIR VRLPGNLLMQ GVFGCHEPFS
AVRVFVASTL SDALSTSEFT LRDAASQLVE DESASLAQLS LAPAALLHVV FAENLSDYGQ
IVADEHIEII QELEASD
