ID   UBXN8_BOVIN             Reviewed;         275 AA.
AC   Q2TBH5;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=UBX domain-containing protein 8;
DE   AltName: Full=UBX domain-containing protein 6;
GN   Name=UBXN8; Synonyms=UBXD6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in endoplasmic reticulum-associated degradation
CC       (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the
CC       endoplasmic reticulum membrane. May play a role in reproduction (By
CC       similarity). {ECO:0000250}.
CC   -!- FUNCTION: May play a role in reproduction. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SYVN1 and VCP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
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DR   EMBL; BC110208; AAI10209.1; -; mRNA.
DR   RefSeq; NP_001033761.1; NM_001038672.2.
DR   AlphaFoldDB; Q2TBH5; -.
DR   SMR; Q2TBH5; -.
DR   STRING; 9913.ENSBTAP00000005462; -.
DR   PaxDb; Q2TBH5; -.
DR   Ensembl; ENSBTAT00000005462; ENSBTAP00000005462; ENSBTAG00000004173.
DR   Ensembl; ENSBTAT00000076763; ENSBTAP00000067731; ENSBTAG00000004173.
DR   GeneID; 509646; -.
DR   KEGG; bta:509646; -.
DR   CTD; 7993; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004173; -.
DR   VGNC; VGNC:36630; UBXN8.
DR   eggNOG; KOG1363; Eukaryota.
DR   GeneTree; ENSGT00390000018326; -.
DR   HOGENOM; CLU_077976_0_0_1; -.
DR   InParanoid; Q2TBH5; -.
DR   OMA; RMTGETW; -.
DR   OrthoDB; 1194290at2759; -.
DR   TreeFam; TF337105; -.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000004173; Expressed in semen and 105 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; ISS:UniProtKB.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR001012; UBX_dom.
DR   InterPro; IPR017247; UBXN8.
DR   Pfam; PF00789; UBX; 1.
DR   PIRSF; PIRSF037632; UBX_Rep6; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50033; UBX; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..275
FT                   /note="UBX domain-containing protein 8"
FT                   /id="PRO_0000260762"
FT   TOPO_DOM        1
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        23..33
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..275
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          192..268
FT                   /note="UBX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT   REGION          137..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..175
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   275 AA;  31335 MW;  9A68B473FF2C1CC5 CRC64;
     MASRGVVGIF LLSALPLLCL ELRRGKPDLG IKDLILLCGR IFLLLALLTL IISVTTSWVN
     SFKPSQVYLK EEEEKNEKRQ KLVRKKQQEA QGEKVSRYIE NVLKPSQEMK LKKLEERFYQ
     MTGETWKLSN GHKLGGDEDL ELDSESQTSF ETSNREAAKR RNLPNSVTNI SPPAEQPTKK
     EVLDLPEEPP ETAEEVVTVA LRCPSGRVLR RRFFKSCSSQ VLFDWMMKLG YRTSLYSLST
     SFPRRPLEVE AGWSLQDIGI TVDTVLNVEE KEQSS