ID   UBX_DROHY               Reviewed;          87 AA.
AC   Q23946;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Homeotic protein ultrabithorax;
DE   Flags: Fragment;
GN   Name=Ubx;
OS   Drosophila hydei (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7224;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY.
RC   TISSUE=Embryo;
RX   PubMed=7911773; DOI=10.1093/genetics/136.3.965;
RA   Bomze H.M., Lopez A.J.;
RT   "Evolutionary conservation of the structure and expression of alternatively
RT   spliced Ultrabithorax isoforms from Drosophila.";
RL   Genetics 136:965-977(1994).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Binds the
CC       consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls
CC       development of the cells in the posterior thoracic and first abdominal
CC       segments. It activates the synthesis of the decapentaplegic (DPP)
CC       growth factor (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=IB;
CC         IsoId=Q23946-1; Sequence=Displayed;
CC       Name=IA;
CC         IsoId=Q23946-2; Sequence=VSP_002401;
CC       Name=IIA;
CC         IsoId=Q23946-3; Sequence=VSP_002402;
CC       Name=IIB;
CC         IsoId=Q23946-4; Sequence=VSP_002404;
CC       Name=IVA;
CC         IsoId=Q23946-5; Sequence=VSP_002403;
CC   -!- TISSUE SPECIFICITY: In the embryo, expression is seen in the epidermis,
CC       somatic and visceral mesoderm, and the peripheral and central nervous
CC       system. {ECO:0000269|PubMed:7911773}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; U03178; AAA03568.1; -; mRNA.
DR   AlphaFoldDB; Q23946; -.
DR   FlyBase; FBgn0012384; Dhyd\Ubx.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; TAS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
PE   2: Evidence at transcript level;
KW   Activator; Alternative splicing; Developmental protein; DNA-binding;
KW   Homeobox; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           <1..>87
FT                   /note="Homeotic protein ultrabithorax"
FT                   /id="PRO_0000200267"
FT   MOTIF           22..27
FT                   /note="Antp-type hexapeptide"
FT   VAR_SEQ         30..72
FT                   /note="Missing (in isoform IVA)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_002403"
FT   VAR_SEQ         30..55
FT                   /note="Missing (in isoform IIA)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_002402"
FT   VAR_SEQ         30..38
FT                   /note="Missing (in isoform IA)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_002401"
FT   VAR_SEQ         39..55
FT                   /note="Missing (in isoform IIB)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_002404"
FT   NON_TER         1
FT   NON_TER         87
SQ   SEQUENCE   87 AA;  9333 MW;  0EE2E34B246E9FED CRC64;
     SGAAAAQTAA ASSLHQASNH TFYPWMAIAG ESTADPIKSK IRSDLTQYGG ISTDMGKRYS
     ESLAGSLLPD WLGTNGLRRR GRQTYTR