UBX_DROPS
ID UBX_DROPS Reviewed; 385 AA.
AC P20822; Q23833; Q297J6;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 3.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Homeotic protein ultrabithorax;
GN Name=Ubx; ORFNames=GA10294;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-259, AND ALTERNATIVE SPLICING
RP (ISOFORMS IA AND IB).
RX PubMed=16453766; DOI=10.1002/j.1460-2075.1987.tb02380.x;
RA Wilde C.D., Akam M.;
RT "Conserved sequence elements in the 5' region of the Ultrabithorax
RT transcription unit.";
RL EMBO J. 6:1393-1401(1987).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 222-298 (ISOFORM IA).
RX PubMed=7911773; DOI=10.1093/genetics/136.3.965;
RA Bomze H.M., Lopez A.J.;
RT "Evolutionary conservation of the structure and expression of alternatively
RT spliced Ultrabithorax isoforms from Drosophila.";
RL Genetics 136:965-977(1994).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Binds the
CC consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls
CC development of the cells in the posterior thoracic and first abdominal
CC segments. It activates the synthesis of the decapentaplegic (DPP)
CC growth factor (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Ia; Synonyms=Major;
CC IsoId=P20822-1; Sequence=Displayed;
CC Name=Ib; Synonyms=Minor;
CC IsoId=P20822-2; Sequence=VSP_036065;
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000070; EAL28209.2; -; Genomic_DNA.
DR EMBL; X05179; CAA28814.1; -; Genomic_DNA.
DR EMBL; X05179; CAA28815.1; -; Genomic_DNA.
DR EMBL; U03179; AAA03569.1; -; mRNA.
DR PIR; A29259; A29259.
DR RefSeq; XP_001359066.2; XM_001359029.3.
DR AlphaFoldDB; P20822; -.
DR SMR; P20822; -.
DR STRING; 7237.FBpp0281796; -.
DR EnsemblMetazoa; FBtr0283358; FBpp0281796; FBgn0243536. [P20822-1]
DR GeneID; 4802074; -.
DR KEGG; dpo:Dpse_GA10294; -.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; P20822; -.
DR OMA; HQNGYAA; -.
DR ChiTaRS; Ubx; fly.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0243536; Expressed in multicellular organism and 1 other tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; TAS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Developmental protein; DNA-binding;
KW Homeobox; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..385
FT /note="Homeotic protein ultrabithorax"
FT /id="PRO_0000200269"
FT DNA_BIND 290..349
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 132..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 243..248
FT /note="Antp-type hexapeptide"
FT VAR_SEQ 252..259
FT /note="KIRSDLTQ -> ECPEDPTK (in isoform Ib)"
FT /evidence="ECO:0000305"
FT /id="VSP_036065"
FT CONFLICT 123
FT /note="Missing (in Ref. 2; CAA28814/CAA28815)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 385 AA; 39512 MW; 780545118A537517 CRC64;
MNSYFEQASG FYGHPHQATG MAMGSGGHHD QTASAAAAAY RGFPLSLGMS PYANHHLQRT
TQDSPYDASI TAACNKIYGD GASAYKQDCL NIKADAVNGY KDIWNTGGSN GGGTGGGGGG
GGAGGNASNG SNAGNAANGQ NNAAGGMPVR PSACTPDSRV GGYLDTSGGS PVSHRGGSAG
GNVSAGGGGQ SGQSGAPGVG VGVGVGVGAG AGTAWNANCT ISGAAAAQTA AASSLHQASN
HTFYPWMAIA GKIRSDLTQY GGISTDMGKR YSESLAGSLL PDWLGTNGLR RRGRQTYTRY
QTLELEKEFH TNHYLTRRRR IEMAHALCLT ERQIKIWFQN RRMKLKKEIQ AIKELNEQEK
QAQAQKAAAA AAAAAAVQGG HLDQN
