ID   UBX_DROSI               Reviewed;         389 AA.
AC   P83950; P02834; Q9TX83; Q9VER4; Q9VER5;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Homeotic protein ultrabithorax;
GN   Name=Ubx;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Tsimbazaza;
RX   PubMed=9853753; DOI=10.1038/24863;
RA   Stern D.L.;
RT   "A role of Ultrabithorax in morphological differences between Drosophila
RT   species.";
RL   Nature 396:463-466(1998).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Binds the
CC       consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls
CC       development of the cells in the posterior thoracic and first abdominal
CC       segments. It activates the synthesis of the decapentaplegic (DPP)
CC       growth factor.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: The QA motif is able to mediate transcriptional repression.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; AF099983; AAD16402.1; -; Genomic_DNA.
DR   EMBL; AF099980; AAD16402.1; JOINED; Genomic_DNA.
DR   EMBL; AF099981; AAD16402.1; JOINED; Genomic_DNA.
DR   EMBL; AF099982; AAD16402.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; P83950; -.
DR   SMR; P83950; -.
DR   ChiTaRS; Ubx; fly.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..389
FT                   /note="Homeotic protein ultrabithorax"
FT                   /id="PRO_0000200270"
FT   DNA_BIND        295..354
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          138..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           239..244
FT                   /note="Antp-type hexapeptide"
FT   MOTIF           368..383
FT                   /note="QA"
FT   COMPBIAS        175..189
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   389 AA;  40040 MW;  D452E8FFE55D8F53 CRC64;
     MNSYFEQASG FYGHPHQATG MAMGSGGHHD QTASAAAAAY RGFPLSLGMS PYANHHLQRT
     TQDSPYDASI TAACNKIYGD GAGAYKQDCL NIKADAVNGY KDIWNTGGSN GGGGGGGGGG
     GGGAGGTGGA GNANGGNAAN ANGQNNPAGG MPVRPSACTP DSRVGGYLDT SGGSPVSHRG
     GSAGGNVSVS GGNGNAGGVQ SGVGVAGAGT AWNANCTISG AAAQTAAASS LHQASNHTFY
     PWMAIAGECP EDPTKSKIRS DLTQYGGIST DMGKRYSESL AGSLLPDWLG TNGLRRRGRQ
     TYTRYQTLEL EKEFHTNHYL TRRRRIEMAH ALCLTERQIK IWFQNRRMKL KKEIQAIKEL
     NEQEKQAQAQ KAAAAAAAAA AVQGGHLDQ