ID   UBX_JUNCO               Reviewed;         253 AA.
AC   Q8T940;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Homeotic protein ultrabithorax;
DE   AltName: Full=JcUbx;
GN   Name=Ubx;
OS   Junonia coenia (Peacock butterfly) (Precis coenia).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Nymphalidae; Nymphalinae; Junonia.
OX   NCBI_TaxID=39708 {ECO:0000312|EMBL:AAL71873.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11859369; DOI=10.1038/nature717;
RA   Galant R., Carroll S.B.;
RT   "Evolution of a transcriptional repression domain in an insect Hox
RT   protein.";
RL   Nature 415:910-913(2002).
RN   [2] {ECO:0000305}
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=7840822; DOI=10.1038/372458a0;
RA   Warren R.W., Nagy L., Selegue J., Gates J., Carroll S.B.;
RT   "Evolution of homeotic gene regulation and function in flies and
RT   butterflies.";
RL   Nature 372:458-461(1994).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Binds the
CC       consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls
CC       development of the cells in the posterior thoracic and first abdominal
CC       segments. {ECO:0000269|PubMed:7840822}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000269|PubMed:7840822}.
CC   -!- TISSUE SPECIFICITY: In the embryo (at 20% embryogenesis), expression is
CC       highest in the first abdominal segment (A1) with significant but
CC       diminishing levels in more posterior thoracic segments (T1 and T3).
CC       {ECO:0000269|PubMed:7840822}.
CC   -!- DOMAIN: The QA motif is able to mediate transcriptional repression.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; AY074760; AAL71873.1; -; mRNA.
DR   AlphaFoldDB; Q8T940; -.
DR   SMR; Q8T940; -.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..253
FT                   /note="Homeotic protein ultrabithorax"
FT                   /id="PRO_0000200272"
FT   DNA_BIND        159..218
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   MOTIF           146..151
FT                   /note="Antp-type hexapeptide"
FT   MOTIF           232..247
FT                   /note="QA"
SQ   SEQUENCE   253 AA;  27677 MW;  ECA23BFD4E78B6D1 CRC64;
     MNSYFEQGGF YGAHGVHQGG GGGDQYRGFP LGLTYAQPHA LHQPRPQDSP YDASVAAACK
     LYAGEQQYAK ADCSKAGGEQ QNGYGGKEAW GSGLGALVRP AACTPEARYS ESSSPGRALP
     WGNQCALPGA AASAQPVQHQ PTNHTFYPWM AIAGANGLRR RGRQTYTRYQ TLELEKEFHT
     NHYLTRRRRI EMAHALCLTE RQIKIWFQNR RMKLKKEIQA IKELNEQEKQ AQAQKAAAAA
     AAAAAAAQGH PEH