ID   UC1_URTCR               Reviewed;          29 AA.
AC   P0CG44;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Cytolysin Uc-1;
DE            Short=UcI {ECO:0000303|PubMed:19232528};
DE   Flags: Fragment;
OS   Urticina crassicornis (Mottled anemone) (Tealia crassicornis).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Urticina.
OX   NCBI_TaxID=45621;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=19232528; DOI=10.1016/j.toxicon.2009.02.007;
RA   Razpotnik A., Krizaj I., Kem W.R., Macek P., Turk T.;
RT   "A new cytolytic protein from the sea anemone Urticina crassicornis that
RT   binds to cholesterol- and sphingomyelin-rich membranes.";
RL   Toxicon 53:762-769(2009).
CC   -!- FUNCTION: Pore-forming toxin that lyses bovine erythrocytes at
CC       nanomolar concentrations. Is devoid of enzymatic activity. Binds to
CC       monolayers and efficiently permeabilizes small lipid vesicles composed
CC       of sphingomyelin and cholesterol. The cytolytic activity is not
CC       prevented by cholesterol or sphingomyelin.
CC       {ECO:0000269|PubMed:19232528}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19232528}.
CC       Nematocyst {ECO:0000269|PubMed:19232528}. Target cell membrane
CC       {ECO:0000269|PubMed:19232528}. Note=Forms a membrane channel in the
CC       prey.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cytolysis; Direct protein sequencing; Hemolysis; Ion transport; Membrane;
KW   Nematocyst; Secreted; Target cell membrane; Target membrane; Toxin;
KW   Transmembrane; Transport.
FT   CHAIN           1..>29
FT                   /note="Cytolysin Uc-1"
FT                   /id="PRO_0000395600"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         29
SQ   SEQUENCE   29 AA;  3080 MW;  6CD1AD7964FF0C1A CRC64;
     DEQTGSKGPN ENLPSQKDLX AKASXLTEV