ID   CA053_HUMAN             Reviewed;         145 AA.
AC   Q5VUE5; A1L4N2; Q5VUE4;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Uncharacterized protein C1orf53;
GN   Name=C1orf53;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=15897902; DOI=10.1038/sj.onc.1208641;
RA   Corson T.W., Huang A., Tsao M.-S., Gallie B.L.;
RT   "KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in
RT   multiple cancers.";
RL   Oncogene 24:4741-4753(2005).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- TISSUE SPECIFICITY: Expressed in retina and retinoblastoma.
CC       {ECO:0000269|PubMed:15897902}.
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DR   EMBL; AL590115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC038214; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC130608; AAI30609.1; -; mRNA.
DR   EMBL; BC130634; AAI30635.1; -; mRNA.
DR   CCDS; CCDS44290.1; -.
DR   RefSeq; NP_001019765.1; NM_001024594.2.
DR   AlphaFoldDB; Q5VUE5; -.
DR   BioGRID; 132826; 2.
DR   STRING; 9606.ENSP00000356363; -.
DR   iPTMnet; Q5VUE5; -.
DR   PhosphoSitePlus; Q5VUE5; -.
DR   BioMuta; C1orf53; -.
DR   EPD; Q5VUE5; -.
DR   jPOST; Q5VUE5; -.
DR   MassIVE; Q5VUE5; -.
DR   MaxQB; Q5VUE5; -.
DR   PaxDb; Q5VUE5; -.
DR   PeptideAtlas; Q5VUE5; -.
DR   PRIDE; Q5VUE5; -.
DR   ProteomicsDB; 65416; -.
DR   Antibodypedia; 55946; 65 antibodies from 10 providers.
DR   DNASU; 388722; -.
DR   Ensembl; ENST00000367393.8; ENSP00000356363.3; ENSG00000203724.11.
DR   GeneID; 388722; -.
DR   KEGG; hsa:388722; -.
DR   MANE-Select; ENST00000367393.8; ENSP00000356363.3; NM_001024594.3; NP_001019765.1.
DR   UCSC; uc001guh.4; human.
DR   CTD; 388722; -.
DR   GeneCards; C1orf53; -.
DR   HGNC; HGNC:30003; C1orf53.
DR   HPA; ENSG00000203724; Tissue enhanced (liver).
DR   neXtProt; NX_Q5VUE5; -.
DR   OpenTargets; ENSG00000203724; -.
DR   PharmGKB; PA142672504; -.
DR   VEuPathDB; HostDB:ENSG00000203724; -.
DR   eggNOG; ENOG502S6IY; Eukaryota.
DR   GeneTree; ENSGT00390000016548; -.
DR   HOGENOM; CLU_141359_0_0_1; -.
DR   InParanoid; Q5VUE5; -.
DR   OMA; YLVLTQI; -.
DR   OrthoDB; 1553807at2759; -.
DR   PhylomeDB; Q5VUE5; -.
DR   TreeFam; TF313973; -.
DR   PathwayCommons; Q5VUE5; -.
DR   BioGRID-ORCS; 388722; 10 hits in 1061 CRISPR screens.
DR   GenomeRNAi; 388722; -.
DR   Pharos; Q5VUE5; Tdark.
DR   PRO; PR:Q5VUE5; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q5VUE5; protein.
DR   Bgee; ENSG00000203724; Expressed in endothelial cell and 132 other tissues.
DR   ExpressionAtlas; Q5VUE5; baseline and differential.
DR   Genevisible; Q5VUE5; HS.
DR   InterPro; IPR040807; DUF5522.
DR   Pfam; PF17653; DUF5522; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..145
FT                   /note="Uncharacterized protein C1orf53"
FT                   /id="PRO_0000271012"
FT   MOD_RES         67
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
SQ   SEQUENCE   145 AA;  15483 MW;  C5475E4B4073223A CRC64;
     MAARQIWART GAALCRQPSA APPPAPLWVR AGFRQQLSLT LCPANEGNCG GSAPSTPGRP
     ERAARPSVSE ELTAAERQIA ELHAAACAAG QLNYVDPATG YVVLTQIAHL QRGECCGSAC
     RHCPYGQVNV KDPSKKKQFN SYFYV