ID   CA054_HUMAN             Reviewed;         131 AA.
AC   Q8WWF1; Q9H5P3;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Uncharacterized protein C1orf54;
DE   Flags: Precursor;
GN   Name=C1orf54;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Adipose tissue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; AK026874; BAB15579.1; -; mRNA.
DR   EMBL; AM392820; CAL37698.1; -; mRNA.
DR   EMBL; AM392958; CAL37836.1; -; mRNA.
DR   EMBL; AM393066; CAL37944.1; -; mRNA.
DR   EMBL; AM393249; CAL38127.1; -; mRNA.
DR   EMBL; AM393548; CAL38425.1; -; mRNA.
DR   EMBL; AM393619; CAL38495.1; -; mRNA.
DR   EMBL; AL138795; CAI22814.1; -; Genomic_DNA.
DR   EMBL; BC017761; AAH17761.1; -; mRNA.
DR   CCDS; CCDS948.1; -.
DR   RefSeq; NP_001287969.1; NM_001301040.1.
DR   RefSeq; NP_078855.2; NM_024579.3.
DR   AlphaFoldDB; Q8WWF1; -.
DR   BioGRID; 122760; 181.
DR   STRING; 9606.ENSP00000358098; -.
DR   GlyGen; Q8WWF1; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8WWF1; -.
DR   PhosphoSitePlus; Q8WWF1; -.
DR   BioMuta; C1orf54; -.
DR   EPD; Q8WWF1; -.
DR   MassIVE; Q8WWF1; -.
DR   PaxDb; Q8WWF1; -.
DR   PeptideAtlas; Q8WWF1; -.
DR   PRIDE; Q8WWF1; -.
DR   Antibodypedia; 20279; 71 antibodies from 12 providers.
DR   DNASU; 79630; -.
DR   Ensembl; ENST00000369099.8; ENSP00000358095.3; ENSG00000118292.9.
DR   Ensembl; ENST00000369102.5; ENSP00000358098.1; ENSG00000118292.9.
DR   GeneID; 79630; -.
DR   KEGG; hsa:79630; -.
DR   MANE-Select; ENST00000369099.8; ENSP00000358095.3; NM_024579.4; NP_078855.2.
DR   UCSC; uc001eud.4; human.
DR   CTD; 79630; -.
DR   DisGeNET; 79630; -.
DR   GeneCards; C1orf54; -.
DR   HGNC; HGNC:26258; C1orf54.
DR   HPA; ENSG00000118292; Low tissue specificity.
DR   neXtProt; NX_Q8WWF1; -.
DR   OpenTargets; ENSG00000118292; -.
DR   PharmGKB; PA142672505; -.
DR   VEuPathDB; HostDB:ENSG00000118292; -.
DR   eggNOG; ENOG502RVU7; Eukaryota.
DR   GeneTree; ENSGT00390000003103; -.
DR   HOGENOM; CLU_130480_0_0_1; -.
DR   InParanoid; Q8WWF1; -.
DR   OMA; WALIQGG; -.
DR   OrthoDB; 1538878at2759; -.
DR   PhylomeDB; Q8WWF1; -.
DR   TreeFam; TF336874; -.
DR   PathwayCommons; Q8WWF1; -.
DR   BioGRID-ORCS; 79630; 9 hits in 1060 CRISPR screens.
DR   GenomeRNAi; 79630; -.
DR   Pharos; Q8WWF1; Tdark.
DR   PRO; PR:Q8WWF1; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8WWF1; protein.
DR   Bgee; ENSG00000118292; Expressed in periodontal ligament and 185 other tissues.
DR   ExpressionAtlas; Q8WWF1; baseline and differential.
DR   Genevisible; Q8WWF1; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR027957; DUF4634.
DR   PANTHER; PTHR37870; PTHR37870; 1.
DR   Pfam; PF15465; DUF4634; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..131
FT                   /note="Uncharacterized protein C1orf54"
FT                   /id="PRO_0000251200"
FT   CONFLICT        121
FT                   /note="C -> R (in Ref. 1; BAB15579)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   131 AA;  14923 MW;  BF9DD72D1A8451F0 CRC64;
     MDVLFVAIFA VPLILGQEYE DEERLGEDEY YQVVYYYTVT PSYDDFSADF TIDYSIFESE
     DRLNRLDKDI TEAIETTISL ETARADHPKP VTVKPVTTEP SPDLNDAVSS LRSPIPLLLS
     CAFVQVGMYF M