UCKD_DICDI
ID UCKD_DICDI Reviewed; 492 AA.
AC Q9GNF0; Q55BI1;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Uridine-cytidine kinase D;
DE EC=2.7.1.48;
DE AltName: Full=Cytidine monophosphokinase D;
DE AltName: Full=Uridine monophosphokinase D;
GN Name=udkD; ORFNames=DDB_G0271146;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=AX2;
RA Schreiner T., Kuspa A., Noegel A.A.;
RT "Potential new binding partners of comitin.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Catalyzes the conversion of uridine into uridine
CC monophosphate and cytidine into cytidine monophosphate in the
CC pyrimidine salvage pathway. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + uridine = ADP + H(+) + UMP; Xref=Rhea:RHEA:16825,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57865, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + cytidine = ADP + CMP + H(+); Xref=Rhea:RHEA:24674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17562, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway;
CC CTP from cytidine: step 1/3.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway;
CC UMP from uridine: step 1/1.
CC -!- SIMILARITY: Belongs to the uridine kinase family. {ECO:0000305}.
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DR EMBL; AY007802; AAG32531.1; -; mRNA.
DR EMBL; AY007803; AAG32532.1; -; Genomic_DNA.
DR EMBL; AAFI02000006; EAL71703.1; -; Genomic_DNA.
DR RefSeq; XP_645631.1; XM_640539.1.
DR AlphaFoldDB; Q9GNF0; -.
DR STRING; 44689.DDB0215349; -.
DR PaxDb; Q9GNF0; -.
DR PRIDE; Q9GNF0; -.
DR EnsemblProtists; EAL71703; EAL71703; DDB_G0271146.
DR GeneID; 8617823; -.
DR KEGG; ddi:DDB_G0271146; -.
DR dictyBase; DDB_G0271146; udkD.
DR eggNOG; KOG4203; Eukaryota.
DR HOGENOM; CLU_028566_0_0_1; -.
DR InParanoid; Q9GNF0; -.
DR OMA; MYLYPPK; -.
DR PhylomeDB; Q9GNF0; -.
DR Reactome; R-DDI-196807; Nicotinate metabolism.
DR UniPathway; UPA00574; UER00637.
DR UniPathway; UPA00579; UER00640.
DR PRO; PR:Q9GNF0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004849; F:uridine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0044211; P:CTP salvage; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR023577; CYTH_domain.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006083; PRK/URK.
DR Pfam; PF01928; CYTH; 1.
DR Pfam; PF00485; PRK; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51707; CYTH; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT CHAIN 1..492
FT /note="Uridine-cytidine kinase D"
FT /id="PRO_0000371327"
FT DOMAIN 290..460
FT /note="CYTH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01044"
FT REGION 36..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 117..124
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 492 AA; 55769 MW; 500FCFCC00B7695A CRC64;
MENRYISRIE TISSHLLSTN DVSSQNESES ITFVKPLPKN KKDHDQSIES DSSFTREKQF
EEELDILGEI NSKTGLFEIK QVPYQLSFDQ GFFHACRAIE ILTEKDPKRI ICLGIAGPVG
AGKTTLANKI GSLVNGVIIS LQDFVKLENV KDNNYDDPVL IDFDKVISTL NELKENKTVI
IPKIVNRKME SRSISLSTSK VIILEGAYAL SARIRPLLDI SVAITGGVHL DLIKSIMRGI
VTSGKNSSKD VLAQITNVVF PMFKAFVEPD LDQAKIKIHS SFNPMSQVVE PVYVCKAKYD
NNKQFFDQFL SSLNVVPVKK NFSDMYLYPP KYGVDGISQA DKRNWIRIRR SEHGQFNITF
YNEMMDGAVN TRPSLNFEIS VKTLGGLLSL GYQIGAILNR TVEVWYDKNG VVITKEYIKE
LEKHFIQIKG HSRREVLDSA EKLKITGNHV PQTFLYLYFK KLKKSKNPNY SKLKPNNTNS
KILKNNKDKK NL
